New Horizons on Non-invasive Brain Stimulation of the Social and Affective Cerebellum

The cerebellum is increasingly attracting scientists interested in basic and clinical research of neuromodulation. Here, we review available studies that used either transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) to examine the role of the posterior cerebellum in different aspects of social and affective cognition, from mood regulation to emotion discrimination, and from the ability to identify biological motion to higher-level social inferences (mentalizing). We discuss how at the functional level the role of the posterior cerebellum in these different processes may be explained by a generic prediction mechanism and how the posterior cerebellum may exert this function within different cortico-cerebellar and cerebellar limbic networks involved in social cognition. Furthermore, we suggest to deepen our understanding of the cerebro-cerebellar circuits involved in different aspects of social cognition by employing promising stimulation approaches that have so far been primarily used to study cortical functions and networks, such as paired-pulse TMS, frequency-tuned stimulation, state-dependent protocols, and chronometric TMS. The ability to modulate cerebro-cerebellar connectivity opens up possible clinical applications for improving impairments in social and affective skills associated with cerebellar abnormalities.

Automated summary

Research on the role of the posterior cerebellum in social and affective cognition using various brain stimulation methods has been reviewed. The functional role of the posterior cerebellum in processes such as mood regulation and social cognition may be explained by a generic prediction mechanism, and could involve different cortico-cerebellar and cerebellar limbic networks. Stimulation approaches such as paired-pulse TMS and frequency-tuned stimulation provide insights into cerebro-cerebellar circuits and potential clinical applications for improving social and affective skills associated with cerebellar abnormalities.