LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming

Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction?

(2020) Robert N Lightowlers et al.   EMBO REPORTS

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

(2019) Hessel Honkoop et al.   eLife

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence

(2018) Mary Mohrin et al.   AGING CELL

The role of mitochondria in stem cell fate and aging

(2018) Hongbo Zhang et al.   DEVELOPMENT

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Cellular and epigenetic drivers of stem cell ageing

(2018) Maria Ermolaeva et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Mesenchymal Stem Cell Failure to Adapt to Glucose Shortage and Rapidly Use Intracellular Energy Reserves Through Glycolysis Explains Poor Cell Survival After Implantation

(2018) Adrien Moya et al.   STEM CELLS

Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner

(2018) Yoshihiro Miyazono et al.   Scientific Reports

Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function

(2018) Mi Jin Kim et al.   Scientific Reports

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis

(2017) Mireille Khacho et al.   HUMAN MOLECULAR GENETICS

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

(2016) Yong-Hee Rhee et al.   BRAIN

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

(2016) Jin Zhang et al.   Cell Stem Cell

Anti-apoptotic Effects of Human Wharton's Jelly-derived Mesenchymal Stem Cells on Skeletal Muscle Cells Mediated via Secretion of XCL1

(2016) SooJin Kwon et al.   MOLECULAR THERAPY

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells

(2016) Craig K. Docherty et al.   Stem Cell Research & Therapy

Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle

(2015) Craig Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration

(2015) Xing Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

(2015) J Pfleger et al.   Cell Death & Disease

Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration

(2014) Mi Lan Kang et al.   BIOMATERIALS

Lin28 sustains early renal progenitors and induces Wilms tumor

(2014) A. Urbach et al.   GENES & DEVELOPMENT

A NovelMitoTimerReporter Gene for Mitochondrial Content, Structure, Stress, and Damagein Vivo

(2014) Rhianna C. Laker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

(2013) Ng Shyh-Chang et al.   CELL

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

(2013) Naohisa Yoshioka et al.   Cell Stem Cell

A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity

(2013) Kristen P. Nickens et al.   MITOCHONDRION

Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism

(2013) Gen Shinoda et al.   STEM CELLS

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

(2012) Jan J Molenaar et al.   NATURE GENETICS

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism

(2011) Elizabeth A. Stoll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

(2011) Sandra Varum et al.   PLoS One

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells

(2011) Shuping Peng et al.   STEM CELLS

Lin28: A MicroRNA Regulator with a Macro Role

(2010) Srinivas R. Viswanathan et al.   CELL

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

(2010) Susan Chung et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells

(2008) James D Kretlow et al.   BMC CELL BIOLOGY

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Nuclear Magnetic Resonance Metabolomic Footprinting of Human Hepatic Stem Cells and Hepatoblasts Cultured in Hyaluronan-Matrix Hydrogels

(2008) William S. Turner et al.   STEM CELLS

Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells

(2008) Chien-Tsun Chen et al.   STEM CELLS

Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken

(2007) Shigetoshi Yokoyama et al.   GENE EXPRESSION PATTERNS