Review
Oncology
Qian Bai, Zhenjie Pan, Ghulam Nabi, Farooq Rashid, Yang Liu, Suliman Khan
Summary: Thyroid cancer is the most common endocrine malignancy, and non-coding RNAs play important roles in its development. Competing endogenous RNA is a mechanism of regulatory interactions, and multiple ceRNA networks are deregulated in thyroid cancer development, metastasis, and drug resistance. Further research on these deregulations is needed for early detection and effective treatment of thyroid cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zhihua Wan, Shanshan Jia, Junhua Lu, Xiangjing Ge, Qinghua Chen
Summary: The overexpression of circ-ATAD1 in tumor tissues of NSCLC patients is associated with poor prognosis. Low expression of circ-ATAD1 or high expression of miR-191-5p can inhibit aggressive behavior of cells, while upregulation of circ-ATAD1 or depletion of miR-191-5p promotes cell aggressiveness. circ-ATAD1 accelerates NSCLC progression by sequestering miR-191-5p and upregulating FOXK1 expression.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Oncology
Guangbing Xiong, Shutao Pan, Jikuan Jin, Xiaoxiang Wang, Ruizhi He, Feng Peng, Xu Li, Min Wang, Jianwei Zheng, Feng Zhu, Renyi Qin
Summary: The study provides a comprehensive review of the role of lncRNAs and miRNAs in the initiation and progression of pancreatic cancer, highlighting the crucial function of ceRNA networks in the biological processes of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Neveen A. A. Hussein, Shehata M. M. El Sewedy, Mohamed M. M. Zakareya, Engy A. A. Youssef, Fawziya A. R. Ibrahim
Summary: This study aimed to detect the expression status of four circRNAs (circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1) in patients with colorectal cancer (CRC) and compare them with healthy controls and non-cancer patients. The results showed that the expression of these circRNAs was significantly up-regulated in cancer patients and showed a tendency of upregulation in non-cancer patients. Furthermore, these circRNAs may have potential roles in the early detection of CRC.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Liping Luo, Pingping Miao, Yao Ming, Jie Tao, Hongchun Shen
Summary: In this study, it was found that the expression of circZFR was upregulated in bladder cancer patients and positively correlated with patient survival rates. Inhibiting circZFR expression suppressed the proliferation, migration, and invasion of BCa cells. Additionally, circZFR was shown to promote BCa progression by upregulating WNT5A expression through sponging miR-545 and miR-1270.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Yang Liu, Suliman Khan, Lin Li, Timo L. M. ten Hagen, Mojtaba Falahati
Summary: Thyroid cancer is the most common malignancy of the endocrine system, with recent research suggesting a significant role of non-coding RNAs in its progression, particularly in the competitive endogenous RNA networks. Understanding these mechanisms could lead to early diagnosis of thyroid cancer patients and the discovery of effective therapeutic targets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Gui-yuan Song, Yong-jian Hu, Nan Zhang, Fei Wang, Tian-zhu Chao, Yao-yao Wu, Yu-feng Li, Ping Xu
Summary: This study reveals the regulatory role of miR-147 in lncRNA-miRNA-mRNA networks and suggests its importance in radioprotection through the regulation of the PI3K/AKT pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Lei Yang, Yong-ning Zhou, Miao-miao Zeng, Nan Zhou, Bin-sheng Wang, Bo Li, Xiao-liang Zhu, Quan-lin Guan, Chen Chai
Summary: Circular RNA-0002570 (circ-0002570) expression is significantly increased in gastric cancer tissues, and patients with higher circ-0002570 expression have shorter survival. Functionally, inhibition of circ-0002570 leads to suppression of cell proliferation, migration, and invasion, and inhibits tumor growth. Mechanistically, miR-587 is antagonized by circ-0002570, promoting VCAN expression.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Chengshun Li, Xiaolan Li, Ziping Jiang, Dongxu Wang, Liqun Sun, Jiaqi Li, Yang Han
Summary: This review discusses the mechanism of flavonoids in cancer treatment through modulating the ceRNA network.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eleonora A. Braga, Marina Fridman, Alexey M. Burdennyy, Elena A. Filippova, Vitaly Loginov, Irina Pronina, Alexey A. Dmitriev, Nikolay E. Kushlinskii
Summary: A decrease in miR-124 expression has been observed in epithelial cancers, and it functions as a suppressor by inhibiting the translation of oncogenic proteins. Epigenetic mechanisms and the effects of long non-coding RNAs and circular RNAs play a significant role in regulating miR-124 expression. The interaction between miR-124 and its partners may be promising targets for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yan Zhang, Xing Li, Jun Zhang, Lin Mao
Summary: The expression of circ-CCDC66 was upregulated in cervical cancer and correlated with later tumor stage and larger tumor size. Circ-CCDC66 can inhibit cervical cancer cell proliferation and migration through regulating the miR-452-5p/REXO1 axis. By modulating this axis, circ-CCDC66 may serve as a potential therapeutic target for cervical cancer intervention.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Zhenjun Huang, Renfeng Shan, Wu Wen, Jianfeng Li, Xiaohong Zeng, Renhua Wan
Summary: This article summarizes the roles and functions of circ-ABCB10 in cancer, aiming to provide a comprehensive understanding for the research on diagnosis and treatment of different types of tumors and related miRNA genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Gang Ma, Guichen Li, Wufeng Fan, Yuanhong Xu, Shaowei Song, Kejian Guo, Zhe Liu
Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Lucas Maciel Vieira, Natasha Andressa Nogueira Jorge, Joao Batista de Sousa, Joao Carlos Setubal, Peter F. Stadler, Maria Emilia Machado Telles Walter
Summary: This study identified diagnostic and prognostic biomarkers for colon, rectum, and rectosigmoid junction cancer using ceRNA networks, highlighting differences in CRC behavior at different anatomical sites. The findings emphasize the importance of correctly identifying the tumor site.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Hongyuan Yu, Junlong Liu, Zhe Zhang, Yuyan Zhu, Jianbin Bi, Chuize Kong
Summary: The study revealed that SNHG12 is up-regulated in ccRCC and its overexpression correlates with poor clinical outcome; Knockdown of SNHG12 inhibits proliferation and migration of RCC cells; SNHG12 competitively sponges miR-30a-3p and up-regulates multiple target genes associated with tumorigenesis in ccRCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)