☆ 4.8 Editorial Material

Partners with a killer: Metabolic signaling promotes inflammatory cell death

CELL (2021)

Journal

CELL

Volume 184, Issue 17, Pages 4374-4376

Publisher

CELL PRESS

DOI: 10.1016/j.cell.2021.07.036

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Categories

Biochemistry & Molecular Biology Cell Biology

Funding

NIH [R01GM127609, P01AI141350]

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Abstract

This study revealed that mTOR Complex 1 regulates the production of ROS in mitochondria, leading to inflammatory cell death mediated by GSDMD. This finding establishes a new mechanistic connection between metabolic signaling and inflammatory cell death.

In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.

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