4.5 Article

Enzymes-Catalyzed Knoevenagel Condensation Promoted by Ionic Liquid and Deep Eutectic Solvent

Journal

CATALYSIS LETTERS
Volume 152, Issue 4, Pages 1215-1223

Publisher

SPRINGER
DOI: 10.1007/s10562-021-03718-1

Keywords

PPL; alpha-amylase from hog pancreas; Ionic liquid; deep eutectic solvent; Knoevenagel condensation

Funding

  1. Natural Science Foundation of Guangdong Province [2018A030307022]
  2. Special Innovation Projects of Common Universities in Guangdong Province [2018KTSCX126]

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The Knoevenagel condensation of acetylacetone and aromatic aldehyde catalyzed by lipase from porcine pancreas (PPL) and alpha-amylase from hog pancreas in ionic liquids and deep eutectic solvents for the first time achieved high yields up to 96.1%. The remarkable features observed in ionic liquids and deep eutectic solvents include mild reaction conditions, enhanced rates, improved yields, and reagents' reactivity different from that in standard organic solvents.
The Knoevenagel condensation of acetylacetone and aromatic aldehyde catalyzed by lipase from porcine pancreas(PPL) and alpha-amylase from hog pancreas in ionic liquids and deep eutectic solvents was achieved for the first time. The highest yields is up to 96.1%. Mild reaction conditions, enhanced rates, improved yields and reagents' reactivity which is different from that in standard organic solvents are the remarkable features observed in ionic liquids and deep eutectic solvents. [GRAPHICS] .

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