Review
Medicine, General & Internal
Aniello Maiese, Paola Frati, Fabio Del Duca, Paola Santoro, Alice Chiara Manetti, Raffaele La Russa, Marco Di Paolo, Emanuela Turillazzi, Vittorio Fineschi
Summary: This systematic review analyzed the potential impacts of COVID-19 on the heart, revealing that SARS-CoV-2 can cause irreversible changes in the heart, increasing cardiac risks in surviving patients. Postmortem analysis is an essential tool to understand the pathological changes caused by COVID-19.
Article
Cardiac & Cardiovascular Systems
Melanie C. Bois, Nicholas A. Boire, Andrew J. Layman, Marie-Christine Aubry, Mariam P. Alexander, Anja C. Roden, Catherine E. Hagen, Reade A. Quinton, Christopher Larsen, Young Erben, Ramanath Majumdar, Sarah M. Jenkins, Benjamin R. Kipp, Peter T. Lin, Joseph J. Maleszewski
Summary: This study provides a detailed evaluation of cardiac pathology in individuals with COVID-19, revealing that nonocclusive fibrin microthrombi are common in active COVID-19 cases but do not typically result in acute ischemic injury. Myocarditis is present in a significant percentage of patients with active and cleared COVID-19, while histological features of resolved infection are variable. Additionally, cardiac amyloidosis may be an added risk factor for severe disease.
Article
Cardiac & Cardiovascular Systems
Marc K. Halushka, Richard S. Vander Heide
Summary: The COVID-19 pandemic is associated with significant cardiovascular involvement, with common cardiovascular histopathological findings reported in autopsied hearts. However, the true prevalence of conditions such as myocarditis may be lower than initially thought. Further research is needed to clarify the exact impact of COVID-19 on cardiovascular health.
CARDIOVASCULAR PATHOLOGY
(2021)
Article
Biology
Lubov Mitrofanova, Igor Makarov, Ekaterina Goncharova, Taiana Makarova, Anna Starshinova, Dmitry Kudlay, Evgeny Shlaykhto
Summary: There is an increased risk of developing heart tumors, particularly cardiac myxomas, in COVID-19 patients, possibly due to the persistence of SARS-CoV-2.
Review
Radiology, Nuclear Medicine & Medical Imaging
Felipe Sanchez Tijmes, Constantin Marschner, Paaladinesh Thavendiranathan, Kate Hanneman
Summary: Globally, more than 650 million people have been infected with the SARS-CoV-2 virus, resulting in COVID-19. Cardiac complications, such as myocardial injury and inflammation, have been recognized in the acute infectious and early recovery phase. As the number of acute COVID-19-related deaths decreases, there is growing interest in post-acute sequelae of COVID-19 (PASC) and other long-term cardiovascular complications. Cardiovascular imaging, including MRI, plays a crucial role in detecting cardiovascular manifestations of COVID-19 in both the acute and long-term phases. This review focuses on the role of cardiac MRI in diagnosing and stratifying the risk of patients with acute and chronic cardiovascular manifestations of COVID-19. Evidence level: 4. Technical efficacy: Stage 3.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Critical Care Medicine
David A. Dorward, Clark D. Russell, In Hwa Um, Mustafa Elshani, Stuart D. Armstrong, Rebekah Penrice-Randal, Tracey Millar, Chris E. B. Lerpiniere, Giulia Tagliavini, Catherine S. Hartley, Nadine P. Randle, Naomi N. Gachanja, Philippe M. D. Potey, Xiaofeng Dong, Alison M. Anderson, Victoria L. Campbell, Alasdair J. Duguid, Wael Al Qsous, Ralph BouHaidar, J. Kenneth Baillie, Kevin Dhaliwal, William A. Wallace, Christopher O. C. Bellamy, Sandrine Prost, Colin Smith, Julian A. Hiscox, David J. Harrison, Christopher D. Lucas
Summary: In fatal COVID-19 cases, abnormal immune responses were found primarily in the lung and reticuloendothelial system, which were not clearly associated with the virus. Tissue-specific immunopathology in COVID-19 implicates a significant role of immune-mediated, virus-independent mechanisms in severe disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Sharon E. Fox, Richard S. Vander Heide
Summary: The SARS-CoV-2 virus has caused a significant impact worldwide, leading to over 88 million cases of COVID-19. The heart is commonly affected in COVID-19, with controversy surrounding the nature and extent of cardiac pathology. Patients infected with SARS-CoV-2 may sustain type 1 myocardial infarction without significant atherosclerotic coronary artery disease, while some present with unclear elevations in troponin enzymes.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Ferrer-Gomez, Hector Pian-Arias, Irene Carretero-Barrio, Antonia Navarro-Cantero, David Pestana, Raul de Pablo, Jose Luis Zamorano, Juan Carlos Galan, Belen Perez-Mies, Ignacio Ruz-Caracuel, Jose Palacios
Summary: This study reported the pathological findings in cardiac samples of 30 patients who died due to Sars-Cov-2 infection, revealing that most patients had modest cardiac pathology and the direct effect of SARS-CoV-2 on cardiac lesions remains to be established.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lael M. Yonker, Zoe Swank, Yannic C. Bartsch, Madeleine D. Burns, Abigail Kane, Brittany P. Boribong, Jameson P. Davis, Maggie Loiselle, Tanya Novak, Yasmeen Senussi, Chi-An Cheng, Eleanor Burgess, Andrea G. Edlow, Janet Chou, Audrey Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, Moshe Arditi, Boris Julg, Adrienne G. Randolph, Galit Alter, Alessio Fasano, David R. Walt
Summary: Blood samples from 16 patients who developed myocarditis after SARS-CoV-2 vaccination were analyzed for antibody and T-cell responses. The immune profiles of these patients were similar to those of vaccinated control subjects, except for the presence of free spike antigen in the blood of myocarditis patients.
Article
Cell Biology
Karel F. A. Van Damme, Levi Hoste, Jozefien Declercq, Elisabeth De Leeuw, Bastiaan Maes, Liesbet Martens, Roos Colman, Robin Browaeys, Cedric Bosteels, Stijn Verwaerde, Nicky Vermeulen, Sahine Lameire, Nincy Debeuf, Julie Deckers, Patrick Stordeur, Pieter Depuydt, Eva Van Braeckel, Linos Vandekerckhove, Martin Guilliams, Sjoerd T. T. Schetters, Filomeen Haerynck, Simon J. Tavernier, Bart N. Lambrecht
Summary: Improvements in COVID-19 treatments require a deeper understanding of disease pathology, particularly for critically ill patients. This study shows that complement activation in COVID-19 is primarily mediated by the alternative pathway and provides a comprehensive atlas of complement alterations during respiratory deterioration. The upstream driver of complement responses is identified as IL-6 and STAT1/3 signaling, which has implications for approved COVID-19 therapies.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Altijana Hromic-Jahjefendic, Abas Sezer, Alaa A. A. Aljabali, Angel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Elrashdy M. Redwan, Debmalya Barh, Kenneth Lundstrom
Summary: COVID-19 vaccines have been widely used to reduce the incidence and disease severity of COVID-19. Recent concerns have been raised about a possible association between COVID-19 vaccines and myocarditis. Myocarditis can be caused by infections, immune reactions, or toxic exposure. The incidence rate of myocarditis after vaccination is lower than that after SARS-CoV-2 infection, and it is more common in adolescent males following mRNA vaccination.
Review
Cardiac & Cardiovascular Systems
Audditiya Bandopadhyay, Alok Kumar Singh, Gyaneshwer Chaubey
Summary: The global wave of crisis caused by the rapid spread of the novel SARS-CoV-2 has profoundly affected national healthcare systems and the global economy, leading to concerns about post-COVID morbidities and their impact on vulnerable populations. Specifically, the long-term cardiovascular complications following SARS-CoV-2 infection in different populations have raised important questions, highlighting the need for ongoing cardiac surveillance for COVID-19 recovered individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Fatma Taher, Athar Eysa, Dalia Fahmy, Ahmed Shalaby, Ali Mahmoud, Moumen El-Melegy, Ahmed Abdel Khalek Abdel Razek, Ayman El-Baz
Summary: This article extracts data from published case reports to summarize the theories of pathogenesis and explore the value of diagnostic tests for cardiovascular complications related to COVID-19. The information provided by these tests helps to better understand the mechanism of myocarditis development and improve management strategies.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Medicine, General & Internal
Elena Vasichkina, Daria Alekseeva, Vadim Karev, Ekaterina Podyacheva, Igor Kudryavtsev, Anzhela Glushkova, Anastasia Y. Starshinova, Dmitry Kudlay, Anna Starshinova
Summary: COVID-19 in children is usually mild, but it can cause multiple organ disorders with poor respiratory symptoms. Cardiac changes are observed in a significant proportion of cases, which can be challenging to diagnose in high-risk groups. This review aims to identify the most significant symptoms of COVID-19-related cardiac involvement and the need for in-depth examination.
Article
Cell Biology
Matteo Fassan, Antonio Collesei, Valentina Angerilli, Marta Sbaraglia, Francesco Fortarezza, Federica Pezzuto, Monica De Gaspari, Gianluca Businello, Margherita Moni, Stefania Rizzo, Giulia Traverso, Veronica Colosso, Elisa Taschin, Francesca Lunardi, Aida Freire Valls, Francesca Schiavi, Cristina Basso, Fiorella Calabrese, Angelo Paolo Dei Tos
Summary: This study identified gene expression changes associated with lung damage caused by SARS-CoV-2 infection and highlighted potential therapeutic targets. Further exploration of the immunopathogenic mechanisms of SARS-CoV-2-induced lung damage is crucial for the development of individualized pharmacological strategies.
Article
Critical Care Medicine
Sharon E. Fox, Aibek Akmatbekov, Jack L. Harbert, Guang Li, J. Quincy Brown, Richard S. Vander Heide
LANCET RESPIRATORY MEDICINE
(2020)
Letter
Medicine, General & Internal
Sharon E. Fox, Fernanda S. Lameira, Elizabeth B. Rinker, Richard S. Vander Heide
ANNALS OF INTERNAL MEDICINE
(2020)
Article
Medicine, General & Internal
Roberta E. Gualtierotti, Sharon Fox, Fernanda Da Silva Lameira, Andrea Giachi, Luca Valenti, Maria Orietta Borghi, Pier Luigi Meroni, Massimo Cugno, Flora Peyvandi
Summary: Nailfold videocapillaroscopic alterations were observed in COVID-19 patients, and these alterations were correlated with biomarkers of inflammation and endothelial perturbation. Nailfold histopathology analysis revealed microvascular damage and microthrombi in some cases. These findings suggest the possibility of non-invasively demonstrating microangiopathy in COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Lacey Falgout, Deborah Hilton
MEDICAL MYCOLOGY CASE REPORTS
(2023)
Article
Gastroenterology & Hepatology
Lacey Falgout, Lawrence L. Gensler
Summary: Hereditary diffuse gastric cancer is a familial form of poorly differentiated signet ring cell carcinoma caused by a mutation in the CDH1/E-cadherin gene. The CDH1 mutation is inherited dominantly and has a high level of penetrance. The diagnosis of SRCC in children is extremely rare. We present a case of SRCC in two sisters (10 and 15 years old) and their 41-year-old father.
ACG CASE REPORTS JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Eric A. Shikatani, Tao Wang, Luke S. Dingwell, Colin White-Dzuro, Abdul Momen, Mansoor Husain
Summary: This study found that GDF5 deficiency can reduce the incidence of cardiac rupture after myocardial infarction and improve survival rates in mice. Additionally, GDF5 deficiency leads to increased myocardial fibrosis and decreased afterload. However, it also results in the occurrence of chronic adverse remodeling.
CARDIOVASCULAR PATHOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Martin Kveton, Lukas Hudec, Ivan Vykopal, Matej Halinkovic, Miroslav Laco, Andrea Felsoova, Wanda Benesova, Ondrej Fabian
Summary: This comprehensive review explores the transformative role of digital pathology and computational pathology, especially through machine learning, in the field of heart transplantation. These methodologies have the potential to enhance diagnostic outcomes and reduce observer variability by extracting valuable information from large datasets beyond human perceptual capabilities. However, challenges such as limited sample sizes, diverse data sources, and the absence of standardized protocols hinder the widespread adoption of these techniques.
CARDIOVASCULAR PATHOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Abhinav Goyal, Andrew J. Layman, Melanie C. Bois, Joseph J. Maleszewski
Summary: This study examined the prevalence and characteristics of Lambl excrescences (LEs) in 403 healthy human hearts and found that the prevalence of LEs in healthy hearts is far lower than previously reported.
CARDIOVASCULAR PATHOLOGY
(2024)
