Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Article
Chemistry, Multidisciplinary
Paulo H. Jr Jr Olivieri, Marcelo B. Jesus, Helena B. Nader, Giselle Z. Justo, Alioscka A. Sousa
Summary: This study reveals that surface glycosaminoglycans (GAGs) can regulate the cellular internalization of nanoparticles. Anionic nanoparticles are hindered by the charged surface GAGs, while cationic nanoparticles interact favorably with GAGs. Further investigation shows that the interaction of nanoparticles with GAGs is different, and heparan sulfate plays a crucial role in the cellular internalization of cationic nanoparticles.
Article
Biochemistry & Molecular Biology
Jens Casper, Laura Nicolle, Melanie Willimann, Evrim Umit Kuzucu, Alan Tran, Perrine Robin, Pascal Detampel, Hiu Man Grisch-Chan, Beat Thony, Jorg Huwyler, Sandrine Gerber-Lemaire
Summary: The study investigates the improvement of nucleic acid delivery by using depolymerized chitosan-polyethylenimine DNA complexes. This modular approach combines core-dCS-linear PEI/DNA complexes with a shell consisting of dCS-PEG-COOH, resulting in improved nucleic acid encapsulation, cellular uptake, and transfection potency. The optimized ternary complex shows high reporter gene signal for three days after administration, indicating its potential for in vitro and in vivo gene delivery.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Asim Mushtaq, Li Li, Anitha A., Lisbeth Grondahl
Summary: Chitosan particles exhibit significant impact on targeted drug delivery, cellular uptake, and tumor growth inhibition. Controlling the physicochemical properties of chitosan particles is crucial for the development of safe and efficient nanomedicine.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Mauro Sousa De Almeida, Patricia Taladriz-Blanco, Barbara Drasler, Sandor Balog, Phattadon Yajan, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: The uptake of nanoparticles by cells can trigger gene expression regulation, specifically related to inflammation, chemotaxis, and cell adhesion. Understanding these cellular processes is important for the approval of new nanomedicines.
Article
Chemistry, Applied
Yemei Sun, Linlin Shang, Xiaoshuang Xia, Di Meng, Yun Ren, Jiaqi Zhang, Man Yao, Xinghua Zhou, Yun Wang
Summary: Chitosan treatment affected the transcriptome and physiological pathways of Penicillium expansum, with up-regulation of the gene encoding clathrin adaptor protein mu-subunit (PeCAM) involved in clathrin-dependent endocytosis. Deletion of PeCAM resulted in morphological changes in fungal cells and reduced sensitivity to chitosan, indicating that chitosan uptake is mediated by clathrin-dependent endocytosis and plays a crucial role in its antifungal activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Biophysics
Naghmeh Akbari Moghadam, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad
Summary: Chitosan-chondroitin sulfate nanoparticles have been synthesized as a platform for efficient gene sequence delivery, showing potential for gene therapy in cartilage diseases.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Haibo Chen, Xuewei Dong, Luping Ou, Chiyun Ma, Bing Yuan, Kai Yang
Summary: In this study, the interaction between irradiated nanoparticles (NPs) and lipid bilayer membranes was investigated using molecular dynamics simulations. The results showed that the wrapping of membranes around NPs is thermally regulated and dependent on NP properties and lipid species. These findings offer valuable insights for understanding cellular internalization of NPs and developing strategies to modulate NP endocytosis.
Article
Chemistry, Multidisciplinary
Erin McGraw, Jonathan D. Roberts, Nitish Kunte, Matthew Westerfield, Xavier Streety, David Held, L. Adriana Avila
Summary: This study investigates the role of endocytosis and transcytosis in the transport of branched amphipathic peptide nanocapsules (BAPCs) associated with dsRNA through midgut epithelium cells. Clathrin-mediated endocytosis and macropinocytosis are found to be responsible for cellular uptake, while transcytosis is involved in shuttling BAPCs-dsRNA from the lumen to the hemolymph.
Article
Physics, Fluids & Plasmas
Ke Xiao, Rui Ma, Chen-Xu Wu
Summary: The study investigates the theoretical model and phenomenon of active entry of self-propelled pathogens into host cells, revealing a wrapping transition triggered by active force. The results may offer guidance for research on the cellular entry of active particles driven by activity.
Article
Pharmacology & Pharmacy
Ammar S. Al Khafaji, Maureen D. Donovan
Summary: Nanoparticles administered via the nasal cavity demonstrated uptake through various endocytic pathways, with continued uptake observed even after exposure to pharmacological inhibitors. The study revealed that a combination of endocytic pathways are involved in the transfer of nanoparticles into the nasal mucosa. Additionally, non-energy-dependent pathways for nanoparticle uptake were observed following exposure to general metabolic inhibitors, highlighting the potential for lipid nanoparticles in local and systemic drug delivery following nasal administration.
Article
Instruments & Instrumentation
Bettina Gabold, Friederike Adams, Sophie Brameyer, Kirsten Jung, Christian L. Ried, Thomas Merdan, Olivia M. Merkel
Summary: Nose-to-brain delivery is a promising alternative for delivering high molecular weight drugs. Transferrin-decorated chitosan nanoparticles can efficiently cross the nasal epithelial barrier and enhance cellular uptake in tumor cells. This approach offers a potential improvement in drug bioavailability through targeted ligand binding.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biophysics
Nazanin Amiryaghoubi, Elaheh Dalir Abdolahinia, Ailar Nakhlband, Shaghayegh Aslzad, Marziyeh Fathi, Jaleh Barar, Yadollah Omidi
Summary: Chitosan-based pH-sensitive nanocomposites were developed for targeted delivery of doxorubicin to osteosarcoma cells. The nanocomposites exhibited enhanced drug release under acidic conditions and showed high cellular uptake and cytotoxicity in folate receptor-expressing cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Ankan Kumar Sarkar, Santanu Shaw, Himali Arora, Pankaj Seth, Nikhil R. R. Jana
Summary: Subcellular targeting of drugs can be enhanced by designing nanocarriers for direct cell membrane translocation, bypassing endosomal/lysosomal trafficking. This approach allows rapid and extensive delivery of drugs to the cell nucleus within a few minutes, without undergoing vesicular coating and lysosomal trafficking. This nonendocytic uptake method provides a potential strategy for nanocarrier-based subcellular targeting of drugs for more effective therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Qingming Bao, Tsogzolmaa Ganbold, Qiburi Qiburi, Mingming Bao, Shuqin Han, Huricha Baigude
Summary: The study found that adenosine receptor A2BR can be utilized for cell type specific siRNA delivery, and CuAMP4 nanoparticles may serve as a promising delivery system for targeted therapeutic siRNAs in cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Sagar Muley, Tanaji Nandgude, Sushilkumar Poddar
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2016)
Article
Pharmacology & Pharmacy
T. D. Nandgude, K. S. Bhise, V. B. Gupta
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2008)
Review
Pharmacology & Pharmacy
Tanaji Nandgude, Ankita Kawtikwar
Summary: Nanoarchitectonics is an emerging multidisciplinary field that offers groundbreaking solutions for various challenging therapies by precise control of physicochemical properties, morphology, and biological effects of nano-sized drugs. Various examples of drug delivery based on nanoarchitectonic approach provide possibilities for significantly expanding the horizon in this area.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Pharmacology & Pharmacy
Vaibhav Salve, Rakesh Mishra, Tanaji Nandgude
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Tanaji D. Nandgude, Priyajit S. Hasabe
ASIAN JOURNAL OF PHARMACEUTICS
(2018)
Review
Pharmacology & Pharmacy
Anil R. Phad, Nandgude Tanaji Dilip, R. Sundara Ganapathy
ASIAN JOURNAL OF PHARMACEUTICS
(2018)
Article
Pharmacology & Pharmacy
Piyush Sanghai, Tanaji Nandgude, Sushilkumar Poddar
JOURNAL OF DRUG DELIVERY
(2016)
Article
Pharmacology & Pharmacy
Nandgude Tanaji Dilip, R. Sundara Ganapathy
ASIAN JOURNAL OF PHARMACEUTICS
(2016)
Review
Pharmacology & Pharmacy
Suraj B. More, Tanaji D. Nandgude, Sushilkumar S. Poddar
ASIAN JOURNAL OF PHARMACEUTICS
(2016)
Review
Pharmacology & Pharmacy
Dhruv K. Purohit, Tanaji D. Nandgude, Sushilkumar S. Poddar
ASIAN JOURNAL OF PHARMACEUTICS
(2016)
Article
Pharmacology & Pharmacy
Otari Kishor Vasant, Bhalsing Gaurav Vijay, Shete Rajkumar Virbhadrappa, Nandgude Tanaji Dilip, Mali Vishal Ramahari, Bodhankar Subhash Laxamanrao
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2012)