Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Medicine, Research & Experimental
Xu Wang, Jie Mao, Tao Zhou, Xingyi Chen, Haoyang Tu, Jinyan Ma, Yixuan Li, Yushi Ding, Yong Yang, Hongxi Wu, Xinying Tang
Summary: The study found that MYDGF can promote the progression of HCC by enhancing the self-renewal of liver CSCs, promoting tumor angiogenesis, and inducing the release of inflammatory cytokines. The findings provide evidence that MYDGF can directly affect the self-renewal of liver CSCs and indirectly exacerbate the inflammatory microenvironment to accelerate HCC progression.
Review
Immunology
Mengyuan Li, Ping Jiang, Shuhua Wei, Junjie Wang, Chunxiao Li
Summary: Recent studies have shown that tumor-associated macrophages play a crucial role in tumor initiation and progression as the most abundant stromal cells in the tumor microenvironment. The proportion of macrophages in the tumor microenvironment is associated with cancer prognosis. These macrophages can polarize into anti-tumorigenic and pro-tumorigenic phenotypes, exerting opposing effects on tumor progression. Additionally, there is extensive communication between tumor-associated macrophages and other immune cells, impacting tumor development and treatment outcomes. Targeting the molecules and signaling pathways involved in these interactions can be a potential immunotherapeutic strategy for malignant tumors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Haibo Qiu, Xu Zhang, Jiali Qi, Jiangwen Zhang, Yin Tong, Lei Li, Li Fu, Yan-Ru Qin, Xinyuan Guan, Liyi Zhang
Summary: This study identified a novel origin of cancer-associated fibroblasts (CAFs) in esophageal squamous cell carcinoma (ESCC) and systematically studied their mobilization, recruitment, and maturation processes. It was found that fibrocytes derived from hematopoietic stem cells (HSCs) could be induced, recruited, and differentiated into functional CAFs by ESCC cells, mediated by FGF2 and the CXCL12/CXCR4 axis. The differentiation process was triggered by direct interaction with tumor cells through the activation of the YAP-TEAD complex. These findings provide new strategies for targeting CAFs and utilizing CAF precursors as cellular vehicles targeting tumor cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maria Kotsari, Vassiliki Dimopoulou, John Koskinas, Athanasios Armakolas
Summary: According to the recently released worldwide cancer data for 2020 by the WHO, liver cancer ranks sixth in morbidity and third in mortality among all malignancies. Hepatocellular carcinoma (HCC), the most common kind of liver cancer, accounts for about 80% of all primary liver malignancies and is one of the leading causes of death globally. The tumor microenvironment, an unresolved issue in clinical practice, plays a crucial role in the development and progression of HCC. This review aims to provide an overview of the HCC immune microenvironment, cellular constituents, current therapies, and potential immunotherapy methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Jinyang Hu, Feng Dong, You He, Xianyou Xia, Fangling Cheng, Sui Chen, Xiaoshuang Hou, Po Zhang, Guohao Liu, Ying Li, Qian Gao, Minhai Dong, Ting Li, Wei Li, Qungen Xiao, Xiaopeng Li, Xingjiang Yu, Guifa Xi, Dongsheng Guo, Xudong Wu, Baofeng Wang
Summary: This study reveals that GBM cells with high level LRIG2 can escape phagocytosis by tumor-associated microglia/macrophages, highlighting the potential of early clinical trials targeting LRIG2 and CD47-SIRP alpha as a novel treatment for GBM.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Federica Papaccio, Daniela Kovacs, Barbara Bellei, Silvia Caputo, Emilia Migliano, Carlo Cota, Mauro Picardo
Summary: Research indicates that cancer-associated fibroblasts play significant roles in tumor growth, extracellular matrix remodeling, and inflammatory response. A thorough understanding of the melanoma-fibroblast relationship can expand treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Sabrina Rizzolio, Silvia Giordano, Simona Corso
Summary: In the last two decades, targeted drugs have revolutionized clinical oncology. However, primary and acquired resistance to these therapies has become a significant limitation, with cancer-associated fibroblasts (CAFs) playing a crucial role. CAFs not only contribute to tumor stroma structure, but also release various molecules that impact tumor properties, including response to drug treatment. The role of CAFs in resistance to targeted therapies, particularly molecular therapies, has been overlooked.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Shi Du, Jiaxian Qian, Shuran Tan, Wenhan Li, Pan Liu, Jing Zhao, Ya Zeng, Linjuan Xu, Zehua Wang, Jing Cai
Summary: In this study, it was found that the number of TEMs increased in cervical cancer tissues with high TIE2 expression and was associated with shorter survival. Further experiments revealed that exosomes derived from TIE2-high cervical cancer cells transported TIE2 protein directly to macrophages, leading to the induction of TEMs. These TEMs promoted tumor angiogenesis and exhibited an M2-like phenotype.
Article
Oncology
Lingli Long, Yue Hu, Tengfei Long, Xiaofang Lu, Ying Tuo, Yubing Li, Zunfu Ke
Summary: This study revealed a positive relationship between the formation of OvCa-TAMs spheroids and the malignancy of OvCa cells, with M2-TAMs inducing the epithelial-mesenchymal transition of OvCa cells through the release of CCL18. The overexpression of ZEB1 in OvCa cells in ovarian mice models promoted the formation of OvCa-TAMs spheroids in ascites, leading to faster transcoelomic metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Jia Li, Zhiqiang Hu, Haoyang Xin, Chubin Luo, Jian Zhou, Jia Fan, Shaolai Zhou
Summary: The interaction between TANs and TAMs enhances the proliferation and invasion abilities of ICC cells, promoting ICC progression. They can produce Oncostatin M and interleukin-11 in co-culture, activating STAT3 signaling in ICC cells, and silencing STAT3 can disrupt the pro-tumor effect of TANs and TAMs on ICC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Sara Magri, Beatrice Musca, Camilla Bonaudo, Ada Tushe, Maria Giovanna Russo, Elena Masetto, Vittorina Zagonel, Giuseppe Lombardi, Alessandro Della Puppa, Susanna Mandruzzato
Summary: Glioblastoma (GBM) is a highly aggressive type of brain cancer with a challenging treatment landscape due to the immunosuppressive tumor microenvironment. This study reveals differences in immune profiles in central and marginal tumor areas, emphasizing the importance of understanding how treatments impact the immune composition for recurrence prevention. Detecting immune landscape changes in GBM relapses can aid in better stratification and treatment approaches.
Review
Cell Biology
Mrinmoy Sarkar, Tristan Nguyen, Esheksha Gundre, Olajumoke Ogunlusi, Mohanad El-Sobky, Biplab Giri, Tapasree Roy Sarkar
Summary: Stromal heterogeneity of tumor microenvironment (TME) is crucial for malignancy and therapeutic resistance. Cancer-associated fibroblasts (CAFs) play a significant role in the tumor stroma, posing challenges to current therapies for breast cancer and other types of cancer. The positive feedback loop between CAFs and cancer cells contributes to the establishment of malignancy and reduces the efficacy of anti-cancer treatments. Understanding CAF-induced therapeutic resistance is important for improving cancer therapy outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Takashi Okumura, Kenoki Ohuchida, Shin Kibe, Chika Iwamoto, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Masafumi Sada, Kohei Horioka, Naoki Mochidome, Makoto Arita, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Shin Kibe, Kenoki Ohuchida, Yohei Ando, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Masaya Shimamoto, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Masafumi Nakamura
Article
Oncology
Hiromichi Nakayama, Kenoki Ohuchida, Akiko Yonenaga, Akiko Sagara, Yohei Ando, Shin Kibe, Shin Takesue, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Koji Shido, Kei Miyoshi, Kohei Nakata, Taiki Moriyama, Yoshihiro Miyasaka, Shigetaka Inoue, Takao Ohtsuka, Kazuhiro Mizumoto, Masafumi Nakamura
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Oncology
Shin Takesue, Kenoki Ohuchida, Tomohiko Shinkawa, Yoshiki Otsubo, Sokichi Matsumoto, Akiko Sagara, Akiko Yonenaga, Yohei Ando, Shin Kibe, Hiromichi Nakayama, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Hiroki Toma, Yohei Tominaga, Kazuhiro Mizumoto, Makoto Hashizume, Masafumi Nakamura
INTERNATIONAL JOURNAL OF ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Christian Dubiella, Benika J. Pinch, Kazuhiro Koikawa, Daniel Zaidman, Evon Poon, Theresa D. Manz, Behnam Nabet, Shuning He, Efrat Resnick, Adi Rogel, Ellen M. Langer, Colin J. Daniel, Hyuk-Soo Seo, Ying Chen, Guillaume Adelmant, Shabnam Sharifzadeh, Scott B. Ficarro, Yann Jamin, Barbara Martins da Costa, Mark W. Zimmerman, Xiaolan Lian, Shin Kibe, Shingo Kozono, Zainab M. Doctor, Christopher M. Browne, Annan Yang, Liat Stoler-Barak, Richa B. Shah, Nicholas E. Vangos, Ezekiel A. Geffken, Roni Oren, Eriko Koide, Samuel Sidi, Ziv Shulman, Chu Wang, Jarrod A. Marto, Sirano Dhe-Paganon, Thomas Look, Xiao Zhen Zhou, Kun Ping Lu, Rosalie C. Sears, Louis Chesler, Nathanael S. Gray, Nir London
Summary: Through screening an electrophilic fragment library, a highly selective and effective Pin1 inhibitor named Sulfopin was developed, showing promising anti-tumor activity by downregulating c-Myc target genes, slowing tumor progression, and improving survival rates in murine models of neuroblastoma and pancreatic cancer.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Akiko Sagara, Kohei Nakata, Tomohiro Yamashita, Weiyu Guan, Pingshan Zhong, Sokichi Matsumoto, Sho Endo, Chika Iwamoto, Koji Shindo, Naoki Ikenaga, Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Masafumi Nakamura
Summary: A new screening platform focusing on the morphological features of PSCs was developed, which identified candidate compounds that suppress PSC activation and tumor growth. Some lead drugs inhibited the proliferation and migration of PSCs and invasion of cancer cells by disrupting tumor-stromal interactions, and significantly decreased production of extracellular matrix molecules.
Review
Neurosciences
Nami Kim, Bin Wang, Kazuhiro Koikawa, Yutaka Nezu, Chenxi Qiu, Tae Ho Lee, Xiao Zhen Zhou
Summary: It has been shown that death-associated protein kinase 1 (DAPK1) plays a critical role in regulating the induction of cis phosphorylated form of tau protein (cis P-tau) after traumatic brain injury (TBI). DAPK1 mediates cis P-tau induction through phosphorylation of Pin1 at Ser71. Genetic deletion of DAPK1 reduces cis Ptau expression, attenuates neuropathology development, and rescues behavioral impairments after TBI.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kazuhiro Koikawa, Shin Kibe, Futoshi Suizu, Nobufumi Sekino, Nami Kim, Theresa D. Manz, Benika J. Pinch, Dipikaa Akshinthala, Ana Verma, Giorgio Gaglia, Yutaka Nezu, Shizhong Ke, Chenxi Qiu, Kenoki Ohuchida, Yoshinao Oda, Tae Ho Lee, Babara Wegiel, John G. Clohessy, Nir London, Sandro Santagata, Gerburg M. Wulf, Manuel Hidalgo, Senthil K. Muthuswamy, Masafumi Nakamura, Nathanael S. Gray, Xiao Zhen Zhou, Kun Ping Lu
Summary: Upregulation of Pin1 in PDAC contributes to the desmoplastic and immunosuppressive TME, but targeting Pin1 with available drugs can synergize with immunotherapy and gemcitabine to induce complete elimination of PDAC.
Article
Oncology
Sokichi Matsumoto, Kohei Nakata, Akiko Sagara, Weiyu Guan, Naoki Ikenaga, Kenoki Ohuchida, Masafumi Nakamura
Summary: In this study, PLGA nanoparticles were used to deliver chloroquine to pancreatic tumors, effectively reducing PSC activation and showing promise as a novel pre-treatment strategy for PDAC.
Article
Oncology
Akiko Sagara, Kohei Nakata, Sokichi Matsumoto, Weiyu Guan, Tomohiko Shinkawa, Chika Iwamoto, Naoki Ikenaga, Kenoki Ohuchida, Masafumi Nakamura
Summary: The study identified compounds that can suppress PSC activation by targeting the 'neuroactive ligand-receptor interaction' pathway, leading to disruption of tumor-stromal interaction. Among these compounds, duloxetine was found to have this suppressive effect.
Article
Gastroenterology & Hepatology
Weiyu Guan, Kohei Nakata, Akiko Sagara, Chika Iwamoto, Sho Endo, Ryota Matsuda, Sokichi Matsumoto, Naoki Ikenaga, Koji Shindo, Taiki Moriyama, Hideya Onishi, Kenoki Ohuchida, Yoshinao Oda, Masafumi Nakamura
Summary: This study reveals a novel mechanism of PSCs activation regulated by autophagy, with ERAP2 identified as a promising therapeutic target that may provide a new strategy for the treatment of PDAC.
Article
Oncology
Toshiro Ogata, Yoshihiko Sadakari, Hiroyuki Nakane, Kazuhiro Koikawa, Hiroki Kanno, Ryo Kohata, Kayoko Endo, Takao Tsukahara, Koichiro Shimonaga, Kazuhisa Kaneshiro, Gentaro Hirokata, Takeshi Aoyagi, Chiyo Tsutsumi, Masahiko Taniguchi
Summary: This study aimed to investigate whether the 5-mFI predicted long-term survival and cause of death in elderly patients who underwent CRC surgery and to determine the risk factors for mortality. The results showed that the 5-mFI score was associated with short- and long-term outcomes and risk factors for mortality unrelated to CRC. Additionally, the 5-mFI score was negatively associated with long-term survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.