Journal
CANCER INVESTIGATION
Volume 40, Issue 6, Pages 554-566Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2021.1944178
Keywords
Dexamethasone; glioma; immunotherapy; PD-1; lymphocyte
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Understanding the impact of dexamethasone on the immune microenvironment in glioma patients is crucial. Clinical studies have linked dexamethasone use to decreased overall survival, while preclinical studies in animal models have shown a reduction in tumor-infiltrating lymphocytes after dexamethasone administration.
Understanding dexamethasone's effect on the immune microenvironment in glioma patients is of key importance. We performed a comprehensive literature review using the NCBI PubMed database for all articles meeting the following search criteria. ((dexamethasone[All Fields]) AND (glioma or glioblastoma)[Title/Abstract]) AND (immune or T cell or B cell or monocyte or neutrophil or macrophage). Forty-three manuscripts were deemed relevant to the topic at hand. Multiple clinical studies have linked dexamethasone use to decreased overall survival while preclinical studies in murine glioma models have demonstrated decreased tumor-infiltrating lymphocytes after dexamethasone administration.
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