Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 195, Issue 2, Pages 249-255Publisher
WILEY
DOI: 10.1111/bjh.17790
Keywords
Epstein-Barr virus; chronic active EBV; defective viral genome
Categories
Funding
- UK Medical Research Council (MRC)/National Institute for Health Research (NIHR)
- Wellcome Trust [204870/Z/16/Z]
- W.T. Henry Wellcome fellowship [206478/Z/17/Z]
- MRC [MR/S022597/1]
- NIHR Imperial Biomedical Research Centre (BRC)
- NIHR UCL/UCLH BRC
- National Institute of Allergy and Infectious Diseases
- Wellcome Trust [206478/Z/17/Z] Funding Source: Wellcome Trust
- MRC [MR/S022597/1] Funding Source: UKRI
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CAEBV is a rare disease characterized by persistent EBV infection, with defective EBV genomes found in East Asian patients. In this study, EBV deletions were observed in blood samples from CAEBV patients but not in saliva samples, and these deletions were lost over time after successful treatment. This suggests that CAEBV is associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.
Chronic active Epstein-Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.
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