Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 194, Issue 1, Pages 145-157Publisher
WILEY
DOI: 10.1111/bjh.17563
Keywords
Respiratory viral infection; Post Transplant Cyclophosphamide; Allogeneic transplant
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Funding
- CIBMTR Infection and Immune Reconstitution Working Committee
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Patients receiving post-transplant cyclophosphamide (PTCy) have a higher incidence of community respiratory viral infections (CRVIs), which may increase the risk of treatment-related mortality and lower overall survival rates compared to those without CRVIs. Further research into long-term antiviral immune recovery and development of preventive strategies are warranted.
Community respiratory viral infections (CRVIs) are associated with pulmonary function impairment, alloimmune lung syndromes and inferior survival in human leucocyte antigen (HLA)-matched allogeneic haematopoietic stem cell transplant (HCT) recipients. Although the incidence of viral infections in HLA-haploidentical HCT recipients who receive post-transplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis is reportedly increased, there are insufficient data describing the incidence of CRVIs and the impact of donor source and PTCy on transplant outcomes. Analysing patients receiving their first HCT between 2012 and 2017 for acute myeloid leukaemia, acute lymphoblastic leukaemia and myelodysplastic syndromes, we describe comparative outcomes between matched sibling transplants receiving either calcineurin-based GVHD prophylaxis (SibCNI, N = 1605) or PTCy (SibCy, N = 403), and related haploidentical transplants receiving PTCy (HaploCy, N = 757). The incidence of CRVIs was higher for patients receiving PTCy, regardless of donor type. Patients in the HaploCy cohort who developed a CRVI by day +180 had both a higher risk of treatment-related mortality [hazard ratio (HR) 2.14, 99% confidence interval (CI) 1.13-4.07; P = 0.002] and inferior 2-year overall survival (HR 1.65, 99% CI 1.11-2.43; P = 0.001) compared to SibCNI with no CRVI. This finding justifies further research into long-term antiviral immune recovery, as well as development of preventive and treatment strategies to improve long-term outcomes in such patients.
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