Journal
EXPERIMENTAL NEUROLOGY
Volume 275, Issue -, Pages 253-260Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2015.06.020
Keywords
Neonatal; Surgical incision; Inflammation; Microglia; Pain; Spinal cord; Dorsal horn; Synapse; Patch clamp; DRG; Primary afferent; Glutamate; GABA; Glycine; Membrane excitability
Categories
Funding
- Medical Research Council UK [MR/K022636/1]
- National Institutes of Health [NS080889]
- MRC [MR/K022636/1] Funding Source: UKRI
- Medical Research Council [MR/K022636/1] Funding Source: researchfish
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS080889] Funding Source: NIH RePORTER
Ask authors/readers for more resources
It has become clear that tissue damage during a critical period of early life can result in long-term changes in pain sensitivity, but the underlying mechanisms remain to be fully elucidated. Here we review the clinical and preclinical evidence for persistent alterations in nociceptive processing following neonatal tissue injury, which collectively point to the existence of both a widespread hypoalgesia at baseline as well as an exacerbated degree of hyperalgesia following a subsequent insult to the same somatotopic region. We also highlight recent work investigating the effects of early trauma on the organization and function of ascending pain pathways at a cellular and molecular level. These effects of neonatal injury include altered ion channel expression in both primary afferent and spinal cord neurons, shifts in the balance between synaptic excitation and inhibition within the superficial dorsal horn (SDH) network, and a 'priming' of microglial responses in the adult SDH. A better understanding of how early tissue damage influences the maturation of nociceptive circuits could yield new insight into strategies to minimize the long-term consequences of essential, but invasive, medical procedures on the developing somatosensory system. (C) 2015 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available