Article
Nutrition & Dietetics
Marsa Dastgheib, Reza Barati-Boldaji, Niki Bahrampour, Reihane Taheri, Mohammad Borghei, Sedigheh Amooee, Mohsen Mohammadi-Sartang, Alexei Wong, Siavash Babajafari, Seyed Mohammad Mazloomi
Summary: This study aimed to investigate the effects of cinnamon, ginger, and metformin on women with PCOS. The results showed that cinnamon and metformin reduced insulin resistance and testosterone levels, while ginger decreased FSH and LH levels, which were not observed following metformin consumption. Therefore, cinnamon and ginger supplementations may potentially be used as alternative treatment in women with PCOS.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Marisol Cortez-Navarrete, Miriam Mendez-del Villar, Esperanza Martinez-Abundis, Luis D. Lopez-Murillo, Miriam de J. Escobedo-Gutierrez, Lizet Y. Rosales-Rivera, Karina G. Perez-Rubio
Summary: This study evaluated the effects of Momordica charantia on anthropometric measures in obese patients, showing no significant reductions in body weight, BMI, waist circumference, and body fat percentage after administration, but significant decreases in triglycerides and very low-density lipoprotein levels.
JOURNAL OF MEDICINAL FOOD
(2022)
Review
Nutrition & Dietetics
Amir Hadi, Arman Arab, Saman Khalesi, Nahid Rafie, Marzieh Kafeshani, Maryam Kazemi
Summary: The supplementation with pro-/synbiotics may be beneficial in reducing total cholesterol levels in adults with MetS. However, there is no evidence supporting the effectiveness of pro-/synbiotics consumption on other anthropometric or metabolic outcomes of MetS. Further investigations with larger sample sizes are needed to confirm these findings.
CLINICAL NUTRITION
(2021)
Article
Oncology
Pamela J. Goodwin, Ryan J. O. Dowling, Marguerite Ennis, Bingshu E. Chen, Wendy R. Parulekar, Lois E. Shepherd, Margot J. Burnell, Rachel Vander Meer, Andrea Molckovsky, Anagha Gurjal, Karen A. Gelmon, Jennifer A. Ligibel, Dawn L. Hershman, Ingrid A. Mayer, Timothy J. Whelan, Timothy J. Hobday, Priya Rastogi, Manuela Rabaglio-Poretti, Julie Lemieux, Alastair M. Thompson, Daniel W. Rea, Vuk Stambolic
Summary: The study demonstrates that metformin compared to placebo leads to significant weight and metabolic improvements in breast cancer patients, with no influence from baseline BMI or insulin, and no differences based on the rs11212617 allele status.
Article
Oncology
Jiahui Huang, Yiwei Tong, Jin Hong, Ou Huang, Jiayi Wu, Jianrong He, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen
Summary: This study aimed to evaluate the efficacy, safety, and metabolic parameters change of metformin combined with TEC in neoadjuvant treatment for breast cancer patients with metabolic abnormality. The results showed that adding metformin did not increase the total pathological complete response rate and disease outcome in breast cancer patients, but it could prevent the increase of total cholesterol and low-density lipoprotein cholesterol after treatment.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Endocrinology & Metabolism
Qing Wen, Song Fang, Yanjing Liang, Yuting Tian, Yiding Chen, Jun Yuan, Qiu Chen
Summary: This study aimed to observe the effect of beinaglutide combined with metformin versus metformin alone on weight loss and metabolic profiles in obese patients with polycystic ovary syndrome. The results showed that the combined treatment was more effective in reducing weight, body mass index, waist circumference, and waist to height ratio compared to metformin monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Andrea Y. Arikawa, Mindy S. Kurzer
Summary: This study found that around 30% of postmenopausal women had a waist circumference greater than 88 cm, and that adequate intake of calcium and vitamin D might be challenging for this population. Age and number of medications taken were significantly associated with waist circumference.
Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Nawaid Usmani, Sunita Ghosh, Karan P. Sanghera, Aldrich D. Ong, Rashmi Koul, Arbind Dubey, Shahida Ahmed, Harvey Quon, Don Yee, Matthew Parliament, Gokulan Sivananthan, William Hunter, Brita Danielson, Lindsay Rowe, Megan McDonald, Julian O. Kim
Summary: This study assessed the effects of metformin on body weight, waist circumference, and metabolic parameters in prostate cancer patients undergoing radiation therapy and androgen deprivation therapy. The results showed that metformin could lower weight at 5 months but not in the long-term. Although it did not significantly reduce increases in waist circumference, metformin was associated with lower low-density lipoprotein cholesterol levels. Conclusions: Further research is needed to determine the role of metformin in mitigating the adverse metabolic and weight changes caused by radiation therapy and androgen deprivation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Endocrinology & Metabolism
Jiaqi Zhang, Chuan Xing, Xiangyi Cheng, Bing He
Summary: This study compared the efficacy and safety of CANA/MET combination therapy and MET monotherapy in overweight and obese women with PCOS. The results suggest that CANA/MET combination therapy may be similar to MET monotherapy in improving menstrual frequency, weight control, hyperandrogenemia, and relieving insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Mahir Yusifov, Sezin Alpaydin Baslo, Betul Tekin, Mucahid Erdogan, Oya Ozturk, Dilek Atakli
Summary: The study showed that MetS was more prevalent in CTS patients. Clinical and electrophysiological features, especially sensory thresholds, may worsen with the presence of MetS, but not the wrist ratio.
NEUROLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Chen-Yu Han, Jia-Ping Lu, Xiao-Mei Ye, Hai-Ying Jin, Wei-Wei Xu, Ping Wang, Min Zhang
Summary: Beinaglutide combined with metformin has a positive effect on metabolic profiles and ADAs in patients with T2D, reducing metabolic dysfunction, lowering LBGI, and weight.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
E. E. Ozturk, H. Yildiz
Summary: Metabolic syndrome is a condition characterized by metabolic abnormalities, with increasing prevalence among the elderly population globally. The study found that the Body Roundness Index was more effective in predicting metabolic syndrome in elderly individuals in Turkey compared to other anthropometric indices.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Chuan Xing, Han Zhao, Jiaqi Zhang, Bing He
Summary: The study aimed to observe the effects of MET monotherapy and MET plus LIRA combination therapy on gonadal and metabolic profiles in overweight patients with PCOS. The results showed that both MET monotherapy and MET plus LIRA combination therapy improved glucose metabolism and relieved insulin resistance in overweight patients with PCOS. Furthermore, MET plus LIRA combination therapy was more effective in improving reproductive abnormalities and hyperandrogenemia compared to MET monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Maria V. Babak, Kai Ren Chong, Peter Rapta, Markella Zannikou, Hui Min Tang, Lisa Reichert, Meng Rui Chang, Vladimir Kushnarev, Petra Heffeter, Samuel M. Meier-Menches, Zhi Chiaw Lim, Jian Yu Yap, Angela Casini, Irina V. Balyasnikova, Wee Han Ang
Summary: The study developed a novel drug complex 3met which can induce deadly metabolic catastrophe in triple-negative breast cancer, reducing tumor burden and significantly improving treatment outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Clinical Neurology
Diane J. Kim, Asha Job, Srinivasa Gokarakonda, Chuan Huang, Lackshminarayana Chekuri, Jessica M. Carbajal, Ricardo Caceda
Summary: The study found that depressed patients with both chronic pain and self-harm behaviors showed higher sensitivity in pressure pain thresholds. Hopelessness was identified as a mediator between depression severity and pain sensitivity. The findings suggest a comprehensive approach including mental health services and pain control is needed for depressed patients with comorbid chronic pain and nonsuicidal self-harm behaviors to achieve effective outcomes.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Yi Gao, Cheng Chang, Xiaxia Yu, Pengjin Pang, Nian Xiong, Chuan Huang
Summary: Volume rendering produces informative 2D images from 3D volume data, but faces challenges of designing complex transfer functions and limitations of traditional 2D input/output devices. NUI-VR2 is a system that combines volume rendering and interactive image segmentation in a virtual reality environment with a natural user interface, overcoming these challenges and dramatically improving the user experience in manipulating and perceiving 3D volumes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Ding, Shenglan Chen, Mario Serrano Sosa, Renee Cattell, Lan Lei, Junqi Sun, Prateek Prasanna, Chunling Liu, Chuan Huang
Summary: This study systematically investigates the effect of peritumoral region sizes in radiomic analysis for prediction performance improvement in breast cancer. The results show that incorporating peritumoral features can improve the accuracy of prediction models.
ACADEMIC RADIOLOGY
(2022)
Article
Clinical Neurology
Megan E. Cosgrove, Jordan R. Saadon, Charles B. Mikell, Patricia L. Stefancin, Leor Alkadaa, Zhe Wang, Sabir Saluja, John Servider, Bayan Razzaq, Chuan Huang, Sima Mofakham
Summary: The integrity of thalamic projections to prefrontal cortex subregions was significantly associated with the return of goal-directed behavior following traumatic brain injury. A linear regression model based on thalamo-prefrontal connections showed 72% accuracy in predicting command-following, supporting the role of thalamo-prefrontal connectivity in recovery after TBI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yinxia Zhao, Tianyun Zhao, Shenglan Chen, Xintao Zhang, Mario Serrano Sosa, Jin Liu, Xianfu Mo, Xiaojun Chen, Mingqian Huang, Shaolin Li, Xiaodong Zhang, Chuan Huang
Summary: This study developed an automated radiomic pipeline using deep learning-based segmentation to detect osteoporosis and abnormal bone density, achieving promising results for early detection and screening.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Chemistry, Analytical
Fengyi Wang, Yaqi Liu, Lu Zhang, Zuhao Zhang, Chuan Huang, Dejin Zang, Haiqing Wang, Shenguang Ge, Jinghua Yu
Summary: A high-sensitivity photoelectrochemical biosensor based on CdS quantum dots sensitized porous hexagonal boron nitride nanosheets and a multiple sites tripodal DNA walker was developed. The biosensor showed excellent linear relationship and detection limit, providing a powerful strategy for early clinical diagnosis and biomedical research.
ANALYTICA CHIMICA ACTA
(2022)
Article
Neurosciences
Chuan Huang, Minos Kritikos, Mario Serrano Sosa, Thomas Hagan, Alan Domkan, Jaymie Meliker, Alison C. Pellecchia, Stephanie Santiago-Michels, Melissa A. Carr, Roman Kotov, Megan Horton, Sam Gandy, Mary Sano, Evelyn J. Bromet, Roberto G. Lucchini, Sean A. P. Clouston, Benjamin J. Luft
Summary: Responders to the 9/11 attacks at the World Trade Center who were exposed to toxic dust and experienced trauma for a long time are at increased risk for developing early-onset dementia and neuroinflammation in the hippocampus and cerebral white matter. The presence of the APOE epsilon 4 allele exacerbates this association.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Materials Science, Ceramics
Zili Zhou, Li-Ao Wang, Lei Wang, Xiang Wang, Quanwei Lv, Chuan Huang
Summary: This study prepared high-strength ceramic lightweight aggregates from oil-based drill cutting pyrolysis residues and examined their formation mechanism and expansion during sintering. It was found that the presence of Al2O3 suppressed the melting process and increased the particle strength. The glass phase also contributed toward the high strength of ceramic materials by adhering to crystal grains and forming a concrete-like structure.
JOURNAL OF ASIAN CERAMIC SOCIETIES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Minos Kritikos, Ana M. Franceschi, Paul Vaska, Sean A. P. Clouston, Chuan Huang, Michael Salerno, Yael Deri, Cheuk Tang, Alison Pellecchia, Stephanie Santiago-Michels, Mary Sano, Evelyn J. Bromet, Roberto G. Lucchini, Sam Gandy, Benjamin J. Luft
Summary: This study reports preliminary findings from imaging studies investigating the presence of Alzheimer's disease biomarkers in World Trade Center responders. The results suggest that these responders with neurocognitive dysfunction may be at an increased risk for a neurodegenerative dementia process.
WORLD JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Xue Li, Jun Huang, Cuiting Wang, Xiaxia Yu, Tianhao Zhao, Chuan Huang, Yi Gao
Summary: This study proposes a computational approach to extract nerves and perineural invasion (PNI) from whole slide histopathology images. The segmentation performances are demonstrated through experiments on prostate cancer and head and neck cancer slides, and significant improvements are achieved using a domain adaptation approach.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keyan Yu, Jia Ying, Tianyun Zhao, Lan Lei, Lijie Zhong, Jiaping Hu, Juin W. Zhou, Chuan Huang, Xiaodong Zhang
Summary: The radiomic features of the infrapatellar fat pad have predictive value for incident radiographic knee osteoarthritis, suggesting their potential as an early quantitative prediction biomarker.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Medicine, General & Internal
Lina Albitar, Tianyun Zhao, Chuan Huang, Mina Mahdian
Summary: The study aimed to develop a deep learning model for automatically detecting and segmenting unobturated MB2 canals depicted in CBCT studies of endodontically obturated maxillary molars. The AI algorithm showed potential in identifying obturated and unobturated canals, but further development and validation are needed for accuracy improvement.
Meeting Abstract
Neurosciences
Mario Serrano-Sosa, Philip Tubiolo, Thomas Hagan, John Williams, Chuan Huang, Jared Van Snellenberg
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Jia Ying, Renee Cattell, Tianyun Zhao, Lan Lei, Zhao Jiang, Shahid M. Hussain, Yi Gao, H-H Sherry Chow, Alison T. Stopeck, Patricia A. Thompson, Chuan Huang
Summary: The presence and persistence of higher breast density are risk factors for breast cancer. This study developed a reliable breast segmentation algorithm for accurate and reproducible breast density measurements. Results showed that both the registration and deep learning segmentation methods exhibited high concordance with manual segmentation, with the registration method performing the best in the test-retest assessment.
VISUAL COMPUTING FOR INDUSTRY BIOMEDICINE AND ART
(2022)
Article
Computer Science, Interdisciplinary Applications
Renee Cattell, Jia Ying, Lan Lei, Jie Ding, Shenglan Chen, Mario Serrano Sosa, Chuan Huang
Summary: Lymph node involvement in breast cancer can increase the risk of recurrence. This study aimed to develop a model for preoperative prediction of sentinel lymph node (SLN) metastasis using deep learning-based (DLB) features and compare it to radiomics. The DLB model outperformed the radiomics model in both validation and independent testing sets, particularly in the independent testing set of dissimilar resolution.
VISUAL COMPUTING FOR INDUSTRY BIOMEDICINE AND ART
(2022)