Article
Surgery
Davide Mastrorilli, Luca Mezzetto, Mario D'Oria, Roberta Fiorini, Sandro Lepidi, Lorenzo Scorsone, Edoardo Veraldi, Gian Franco Veraldi
Summary: The aim of this study was to evaluate the prognostic effect of the National Institutes of Health stroke scale (NIHSS) score for patients who had undergone acute carotid endarterectomy (CEA) and to assess the clinical and morphologic factors that could predict for worse outcomes. The study found that patients with an NIHSS score >4 at admission had a higher risk of functional dependence at hospital discharge and 90 days after the index stroke event.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Clinical Neurology
William D. Mulkerin, Ilanit Spokoyny, Jonathan T. Francisco, Brandon Lima, Megan D. Corry, Matthew J. R. Nudelman, Kian Niknam, Ian P. Brown, Michael A. Kohn, Prasanthi Govindarajan
Summary: In this prospective study conducted over a 20-month period, the agreement between prehospital and hospital mNIHSS assessments was found to be reasonable, with mNIHSS >= 8 showing moderate sensitivity in predicting large vessel occlusions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Bastian Cheng, Ji Chen, Alina Koenigsberg, Carola Mayer, Leander Rimmele, Kaustubh R. Patil, Christian Gerloff, Gotz Thomalla, Simon B. Eickhoff
Summary: This study used advanced machine learning techniques to analyze the dimensional structure of NIHSS and identified a five-dimensional representation, including left motor deficits, right motor deficits, dysarthria and facial palsy, language, and deficits in spatial attention and gaze. The study also validated the neurobiological basis of these dimensions through neuroanatomical and functional analysis, providing a valuable anatomical map for individualized stroke treatment and rehabilitation.
Article
Clinical Neurology
Michelle Y. Zhang, Michael Mlynash, Kristin L. Sainani, Gregory W. Albers, Maarten G. Lansberg
Summary: This study aimed to create a model predicting mRS scores in ischemic stroke patients at discharge to day 90, successfully using data from three prospective studies to develop the model and achieving high accuracy in predicting mRS scores within one point in an external validation set.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Fana Alemseged, Alessandro Rocco, Francesco Arba, Jaroslava Paulasova Schwabova, Teddy Wu, Leone Cavicchia, Felix Ng, Jo Lyn Ng, Henry Zhao, Cameron Williams, Fabrizio Sallustio, Anna H. Balabanski, Ales Tomek, Mark W. Parson, Peter J. Mitchell, Marina Diomedi, Nawaf Yassi, Leonid Churilov, Stephen M. Davis, Bruce C. Campbell
Summary: By developing the POST-NIHSS, the prognostic accuracy for posterior circulation stroke patients with mild-moderate symptoms can be improved, and it can help identify patients with NIHSS<10 who are at higher risk of poor outcome.
Article
Clinical Neurology
Xiaoying Chen, Jingwei Li, Craig S. Anderson, Richard Lindley, Maree L. Hackett, Thompson Robinson, Pablo M. Lavados, Xia Wang, Hisatomi Arima, John Chalmers, Candice Delcourt
Summary: The study demonstrates the utility of the structured, simplified modified Rankin scale questionnaire in acute stroke research, showing high reliability and agreement with the standard modified Rankin scale. It can be used as a reliable alternative measure of functional status after acute ischemic stroke.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Manuel Cappellari, Valentina Saia, Giovanni Procucci, Fainardi Enrico, Arturo Consoli, Sergio Nappini, Lucio Castellon, Sandra Bracco, Mauro Bergui, Mirco Cosottini, Alessandra Briatico Vangosa, Sergio Vinci, Maria Ruggiero, Edoardo Puglielli, Luigi Chiumarulo, Giacomo Cester, Chiara Comelli, Umberto Silvagni, Daniele Morosetti, Valentina Caldiera, Nicola Cavasin, Valeria Ledda, Giuseppina Sanfilippo, Andrea Saletti, Pietro Filauri, Ivan Gallesio, Nunzio Paolo Nuzzi, Pitero Amista, Cecilia Zivelonghi, Mauro Plebani, Marco Pavia, Daniele Romano, Francesco Biraschi, Roberto Menozzi, Roberto M. Gasparotti, Andrea Giorgianni, Andrea Zini, Domenico Inzitari, Danilo Toni, Salvatore Mangiafico
Summary: The Careggi Collateral Score (CCS) is a helpful tool for predicting outcomes in stroke patients undergoing thrombectomy for middle cerebral artery occlusion. A higher CCS score is associated with better prognosis, with CCS >= 3 being the optimal threshold for predicting excellent outcomes and CCS >= 1 for predicting survival.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Natalia Pozarowszczyk, Iwona Kurkowska-Jastrzebska, Iwona Sarzynska-Dlugosz, Maciej Nowak, Michal Karlinski
Summary: The aim of this study was to assess the consistency between neurologists and physical and rehabilitation medicine physicians in using the Modified Rankin Scale (mRS) to rate post-stroke disability. The results showed a modest agreement in using mRS, but it may be considered sufficient for observational studies or stroke registries.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Razia Sultana, Ara Dr. Shahin, Haque Md. Jawadul
Summary: This study found that the combination of carbimazole and antioxidant supplements significantly reduced oxidative stress and improved total antioxidant capacity in hyperthyroid patients. Antioxidant supplementation could potentially be used as an adjuvant therapy to improve thyroid function in hyperthyroidism.
Article
Multidisciplinary Sciences
Chih-Wei Sung, Jen-Tang Sun, Edward Pei-Chuan Huang, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, Sabariah Faizah Jamaluddin, Do Ngoc Son, Ming-Ju Hsieh, Matthew Huei-Ming Ma, Li-Min Hsu, Wen-Chu Chiang
Summary: This study investigated the association between prehospital fluid resuscitation and outcomes of trauma patients in Asia. The results showed that prehospital fluid resuscitation was associated with higher in-hospital mortality and poor functional outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Lipeng Li, Tengfei Feng, Ruiting Wu, Yaling Zhang, Ning Wang, Mengqi Wu, Yaxian Pang, Sujuan Yang, Aimin Yang, Dengsuo Zhang, Guimin Hao, Rong Zhang
Summary: Accumulating evidence suggests that exposure to air pollution is associated with decreased sperm quality in men, and seminal plasma plays a vital role in maintaining sperm viability. However, the role of seminal plasma in air pollution-induced decline in sperm quality remains unclear. In this study, 524 participants were recruited from couples undergoing in vitro fertilization treatment in China, and various sperm parameters and air pollutant exposures were measured. The results showed that PM10 exposure was negatively associated with sperm motility, and PM2.5 and PM10 exposures were inversely related to sperm progressive motility during the epididymal stage. Additionally, PM2.5 and PM10 exposures were positively associated with seminal plasma MDA and negatively associated with seminal plasma T-AOC during the epididymal stage. Moreover, PM2.5, PM10, and CO exposures during the total sperm cycle period may be related to increased seminal plasma testosterone. Mediation analysis indicated that seminal plasma MDA and T-AOC partially mediated the negative effect of PM10 on sperm motility during the epididymal stage. Overall, this study suggests that MDA and T-AOC in seminal plasma play a role in the air pollution-associated decline in sperm motility.
ENVIRONMENTAL POLLUTION
(2023)
Article
Clinical Neurology
Adriana Henriques Silva, Pedro Nascimento Alves, Ana Catarina Fonseca, Teresa Pinho-e-Melo, Isabel Pavao Martins
Summary: The National Institutes of Health Stroke Scale (NIHSS) may not accurately predict lesion volume in patients with neglect, but modifying the neglect scoring rules could enhance its predictive capacity.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Rehabilitation
Yan Gao, Yulong Wang, Dongxia Li, Jingpu Zhao, Zhiyuan Dong, Jing Zhou, Guanqi Fu, Jing Zhang
Summary: This study explored the correlations and differentiate ability among the Longshi Scale, Barthel Index, and modified Rankin Scale in stroke patients. The results indicate that the Longshi Scale has better ability than the modified Rankin Scale in differentiating disability, especially for patients with higher levels of activities of daily living.
CLINICAL REHABILITATION
(2021)
Article
Clinical Neurology
Amber R. Comer, Evan Templeton, Michelle Glidden, Stephanie Bartlett, Lynn D'Cruz, Donya Nemati, Samantha Zabel, James E. Slaven
Summary: Little consistency was found between initial NIHSS scores provided by neurologists and registered nurses in clinical practice. Around 34.7% of the scores had a clinically meaningful difference of two points or greater. Higher NIHSS scores and aphasia were associated with inconsistency in scoring between neurologists and emergency room RNs.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anesthesiology
Alana M. Flexman, Clara N. H. Kim, Tyler Plyley, Fidel Vila-Rodriguez, Adrian W. Gelb, Thalia S. Field
Summary: This study aimed to evaluate the perioperative changes in mNIHSS score in noncardiac, non-neurological surgery patients, showing an increase in mNIHSS score on postoperative day 0 but not on postoperative day 1 or 2. The time to complete the mNIHSS assessment was extended postoperatively, and baseline MoCA score was correlated with mNIHSS score change.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Rheumatology
Fatemeh Amiri, Ali-Asghar Kolahi, Seyed Aria Nejadghaderi, Maryam Noori, Alireza Khabbazi, Mark J. M. Sullman, Jay S. Kaufman, Gary S. Collins, Saeid Safiri
Summary: This study examines the burden of gout and its risk factors in the Middle East and North Africa (MENA) region. Data from the Global Burden of Disease 2019 study reveals an increase in the prevalence and incidence rates of gout in the region. High body mass index (BMI) was found to be the largest contributor to the burden of gout in MENA.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mahsa Abolghasemi, Sepide Ali Ashrafi, Milad Asadi, Dariush Shanehbandi, Saeed Sadigh Etehad, Elham Poursaei, Seyed Aria Nejadghaderi, Sheida Shaafi
Summary: This study analyzed the expression of selected microRNAs (miRNAs) associated with multiple sclerosis (MS) in an Iranian population. The results showed a significant decrease in the relative expression of miR-10, miR-21, and miR-124 in MS patients compared to healthy individuals. The findings suggest that altered expression patterns of miRNAs may be involved in MS development. Further large-scale observational studies are recommended.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Orthopedics
Saeid Safiri, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Gary S. Collins, Jay S. Kaufman, Catherine L. Hill, Ali-Asghar Kolahi
Summary: This study aimed to report, compare and contextualize the prevalence, incidence, and years lived with disability (YLDs) of low back pain in the Middle East and North Africa (MENA) region from 1990 to 2019. The burden of low back pain in MENA slightly decreased during this period, with a higher burden among males than the global average. More integrated healthcare interventions are needed to alleviate the burden of low back pain in this region.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Saeid Safiri, Maryam Noori, Seyed Aria Nejadghaderi, Seyed Ehsan Mousavi, Mark J. M. Sullman, Mostafa Araj-Khodaei, Kuljit Singh, Ali-Asghar Kolahi, Kurosh Gharagozli
Summary: This study reports the prevalence, death and disability-adjusted life-years (DALYs) attributable to Parkinson's disease (PD) in the Middle East and North Africa (MENA) region and its 21 countries between 1990 and 2019. The point prevalence of PD in MENA increased by 15.4% and the death rate increased by 2.3% from 1990 to 2019. The highest DALY rates of PD in 2019 were found in Qatar and the lowest in Kuwait.
Article
Public, Environmental & Occupational Health
Seyed Aria Nejadghaderi, Naser Ahmadi, Mohammad-Mahdi Rashidi, Ali Ghanbari, Maryam Noori, Mohsen Abbasi-Kangevari, Maryam Nasserinejad, Negar Rezaei, Moein Yoosefi, Nima Fattahi, Erfan Ghasemi, Yosef Farzi, Elham Abdolhamidi, Mahbobeh Darman, Shirin Djalalinia, Farshad Farzadfar
Summary: This study aimed to describe the age and sex pattern of physical activity domains, insufficient physical activity (IPA), the intensity of physical activity, sedentary behavior, and their associates at Iran's national and provincial levels in 2021. The prevalence of IPA was considerably high in Iran, and the health system should prioritize increasing physical activity, especially in urban areas and among females.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Public, Environmental & Occupational Health
Hoomaan Ghasemi, Sina Kazemian, Seyed Aria Nejadghaderi, Mahan Shafie
Summary: This study reviewed studies on TTS associated with COVID-19 infection, vaccine, and other COVID-19-related etiologies. It found that TTS is rare in patients with COVID-19 but could lead to higher mortality and morbidity. Therefore, individuals with COVID-19, especially elderly women, who present with dyspnea and elevated levels of brain natriuretic peptide and troponin should be evaluated for TTS.
HEALTH SCIENCE REPORTS
(2023)
Article
Geriatrics & Gerontology
Saeid Safiri, Maryam Noori, Seyed Aria Nejadghaderi, Seyed Ehsan Mousavi, Mark J. M. Sullman, Mostafa Araj-Khodaei, Gary S. Collins, Ali-Asghar Kolahi, Kurosh Gharagozli
Summary: Alzheimer's disease (AD) is the leading cause of dementia with increasing prevalence and burden in the Middle East and North Africa (MENA) region. This study analyzed data from 1990 to 2019 and found that the prevalence, death rates, and disability-adjusted life years (DALYs) of dementia have increased. Afghanistan had the highest DALY rate, while Egypt had the lowest. The burden of dementia was higher in females and increased with age. The DALY rate of dementia decreased with increasing sociodemographic index but slightly increased at an SDI of 0.75.
Review
Oncology
Seyed Aria Nejadghaderi, Maryam Balibegloo, Maryam Noori, Farimah Fayyaz, Amene Saghazadeh, Nima Rezaei
Summary: Immunotherapy has shown promise in cancer treatment, and bispecific antibodies (BsAbs) are antibody constructs that can bind to two different epitopes. This systematic review and meta-analysis aimed to evaluate the clinical efficacy and safety of BsAbs in solid tumors, and found that BsAbs did not significantly improve overall survival, progression-free survival, objective response rate, and disease control rate compared to conventional therapies, but did increase the rate of stable disease. Further high-quality randomized controlled trials on BsAbs in solid tumors are recommended.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Gastroenterology & Hepatology
Seyed Aria Nejadghaderi, Ali-Asghar Kolahi, Maryam Noori, Mark J. M. Sullman, Saeid Safiri
Summary: Pancreatic cancer in the Middle East and North Africa (MENA) region has shown a clear and substantial increase in burden, with a high incidence and death rate. Smoking, high fasting plasma glucose, and high body mass index are significant risk factors for pancreatic cancer in the region. Prevention programs should target these risk factors to combat the rising burden.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Psychology, Developmental
Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Shahrokh Amiri, Ali-Asghar Kolahi
Summary: This study aimed to report the burden of ADHD in the Middle East and North Africa (MENA) region from 1990 to 2019. Data on the burden of ADHD were retrieved from the Global Burden of Disease study 2019. The results showed a decrease in the burden of ADHD in MENA from 1990 to 2019, with lower prevalence and years lived with disability (YLD) rates. The highest YLD rate was found in the 10 to 14 age group, and there were no significant gender differences.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Multidisciplinary Sciences
Amin Daei Sorkhabi, Asra Fazlollahi, Aila Sarkesh, Reza Aletaha, Hamidreza Feizi, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Ali-Asghar Kolahi, Saeid Safiri
Summary: Further research is needed on the efficacy and safety of veliparib for treating lung cancer. Clinical trials have shown that the combination of veliparib and chemotherapy may increase the risk of adverse events, with no significant improvement in overall survival, progression-free survival, and objective response rate.
Review
Nutrition & Dietetics
Asra Fazlollahi, Kimia Motlagh Asghari, Cynthia Aslan, Maryam Noori, Seyed Aria Nejadghaderi, Mostafa Araj-Khodaei, Mark J. M. Sullman, Nahid Karamzad, Ali-Asghar Kolahi, Saeid Safiri
Summary: This study conducted a systematic review to examine the relationship between olive oil consumption and cognition. The review included eleven studies, which consistently found that olive oil consumption had a favorable effect on cognitive performance and was positively associated with cognitive health. However, further large-scale investigations are needed to strengthen this conclusion.
FRONTIERS IN NUTRITION
(2023)
Review
Endocrinology & Metabolism
Moein Zangiabadian, Amir Ghaffari Jolfayi, Seyed Aria Nejadghaderi, Ladan Amirkhosravi, Mojgan Sanjari
Summary: Heavy metals exposure may increase the risk of obesity, with mercury and barium exposure increasing the risk, while lead exposure reducing it.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2023)
Review
Public, Environmental & Occupational Health
Pourya Shokri, Mahdi Zahmatyar, Mahdi Falah Tafti, Mobin Fathy, Mohammadmahdi Rezaei Tolzali, Amir Ghaffari Jolfayi, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Ali-Asghar Kolahi, Saeid Safiri
Summary: This study aimed to investigate the non-spinal causes of low back pain (LBP) to reduce the burden it poses on individuals and society. Non-spinal causes of LBP include diseases such as kidney stones, endometriosis, tumors, fibromyalgia, as well as psychological disorders and pregnancy. Various factors such as socioeconomic level, genetics, age, habits, diet, and psychological status can impact the perceived intensity of LBP.
HEALTH SCIENCE REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Somayeh Marghoub, Sarvin Sanaie, Mark J. M. Sullman, Seyed Aria Nejadghaderi, Saeid Safiri, Reza Mohammadinasab
Summary: Obesity was seen as a symbol of wealth and social privilege in ancient times, but it has now been recognized as a disease that needs to be treated seriously. Traditional Iranian medicine emphasizes prevention and a healthy lifestyle, and provides recommendations for preventing and treating obesity.
HEALTH SCIENCE REPORTS
(2023)