Article
Gastroenterology & Hepatology
Yu Huang, Daisuke Miyamoto, Pei-Lin Li, Yusuke Sakai, Takanobu Hara, Tomohiko Adachi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Wei-Li Gu, Susumu Eguchi
Summary: In an aging society, understanding the impact of hepatocyte age on liver donation can help expand alternative cell sources to address liver donor shortages. Research has shown that aged rat hepatocytes still have reprogramming potential, as they can be converted into CLiP cells expressing progenitor cell markers, although their proliferative rate is lower compared to young hepatocytes. Furthermore, treatment with hepatocyte growth factor (HGF) can promote proliferation and CLiP conversion in aged hepatocytes, suggesting that hepatocytes from aged donors may serve as a viable alternative cell source.
HEPATOLOGY RESEARCH
(2021)
Review
Hematology
Nayoung Kwon, Evrett N. Thompson, Madeline Y. Mayday, Vanessa Scanlon, Yi-Chien Lu, Diane S. Krause
Summary: This review provides insights into our current understanding of fate decisions in bipotent megakaryocyte-erythroid progenitors (MEPs), discussing isolation of primary human MEP, gene expression patterns, transcription factors, and external factors involved in MEP fate determination, with an overview of debates in the field. Understanding MEP fate is crucial for studying diseases like anemia and leukemia, and MEP also serve as a model system for studying cell fate decisions, applicable to stem/progenitor cell biology.
CURRENT OPINION IN HEMATOLOGY
(2021)
Article
Genetics & Heredity
Fabrizio Martelli, Paola Verachi, Maria Zingariello, Maria Mazzarini, Alessandro M. Vannucchi, Annalisa Lonetti, Barbara Bacci, Giuseppe Sarli, Anna Rita Migliaccio
Summary: The study revealed that hGATA1 can rescue the anemia and thrombocytopenia caused by Gata1(low) mutation, but is ineffective in rescuing the megakaryocyte defect.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Jelena Vukelic, Renata Dobrila-Dintinjana, Blazen Marijic, Diana Marzic, Tamara Braut, Marko Velepic
Summary: The study found that Epo and EpoR are expressed in malignant laryngeal tumors, with Epo expression levels showing a significant difference in survival. However, there was no significant correlation between Epo and EpoR expression levels and other clinical and pathological features of the tumor. Further studies are needed to better understand the role of Epo and EpoR in the treatment of patients with laryngeal cancer.
Article
Biology
Kazuki Omata, Ikki Nomura, Akito Hirata, Yuka Yonezuka, Hiroshi Muto, Ryo Kuriki, Kirin Jimbo, Koujin Ogasa, Takashi Kato
Summary: Xenopus liver maintains erythropoietic activity from larval to adult stage. During metamorphosis, a globin switch occurs, and the whole-body mass and liver also change. We developed a method to isolate and evaluate erythroid progenitors using monoclonal ER9 antibodies and Acridine orange staining. Our findings show increased erythropoiesis in the froglet liver and demonstrate growth-dependent changes in erythropoiesis patterns in specific organs of Xenopus.
Review
Oncology
Katherine Louise Harper, Timothy James Mottram, Adrian Whitehouse
Summary: Circular RNAs (circRNAs) play vital roles in cellular processes, including gene expression modulation and protein interactions. Dysregulated circRNAs have a significant impact on disease progression, especially in cancer, potentially serving as novel therapeutic targets.
Article
Nanoscience & Nanotechnology
Yue Ding, Yong Shi, Wei Xiong, Jian Heng Sun, Cheng Li, Ya Qi Zhang, Jing Guo
Summary: In this study, a CuFe-N/C bimetallic catalyst was prepared and applied for CO selective catalytic reduction of NO. The synergistic effect of bimetallic Cu-Fe sites was revealed, providing insights into the electron transfer mechanism and laying the foundation for understanding N-coordinated bimetallic site synergy and designing highly active catalysts.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Plant Sciences
Chanika D. Jayasinghe, Wanigasekera D. Ratnasooriya, Sirimal Premakumara, Preethi V. Udagama
Summary: This study investigated the cellular mechanisms of platelet augmentation activity of mature leaf juice from Sri Lankan wild-type Carica papaya and confirmed its potential in increasing platelets by stimulating bone marrow megakaryocytes, regulating thrombopoietic cytokines, and reducing peripheral platelet destruction. The study also found that papaya leaf juice has pro-coagulation and fibrinolysis activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Neurosciences
Zhen-Hong Yang, Si-Jia Zhang, Hai-Ping Zhao, Fang-Fang Li, Zhen Tao, Yu-Min Luo, Rong-Liang Wang
Summary: This study investigated the effects of erythropoietin (EPO) on the differentiation of neural stem cells (NSCs)/neural progenitors (NPs) in hypoxic-ischemic injury. Results showed that EPO promoted the differentiation of NSCs/NPs into oligodendrocytes and astrocytes, while inhibiting neuronal differentiation. The EPO receptor/β common receptor heterodimer was found to be present on the surface of fetal NSCs/NPs and involved in glial differentiation. The study provides insights into the potential mechanisms of EPO in treating hypoxic-ischemic injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Engineering, Environmental
Meysam Salari, Nello D. Sansone, Zahir Razzaz, Sara Mohseni Taromsori, Matthew Leroux, Chul B. Park, Patrick C. Lee
Summary: In this study, a combined hybrid and hierarchical approach was utilized to enhance the multifunctional properties of carbon-based composites. The addition of glass fibers (GFs) as a secondary micro-sized filler, along with a coating of graphene nanoplatelets (GNPs) on polypropylene (PP) composites, resulted in significant improvements in electrical conductivity, permittivity, electromagnetic shielding effectiveness, thermal conductivity, and tensile strength. These enhancements make the hybrid composites suitable for various practical applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Masahiro Saito, Keisuke Saito, Hiroshi Ishikita
Summary: Despite the abundance of iron on earth, manganese serves as the catalytic center for water splitting in photosystem II. In order to understand why nature employs manganese instead of iron, a study investigated the Fe4CaO5 cluster in the PSII protein environment using a QM/MM approach. It was found that substituting manganese with iron resulted in protonation of mu-oxo bridges, highlighting the relevance of manganese in natural water splitting.
Article
Dermatology
James G. Krueger, John Frew, Gregor B. E. Jemec, Alexa B. Kimball, Brian Kirby, Falk G. Bechara, Kristina Navrazhina, Errol Prens, Kristian Reich, Eva Cullen, Kerstin Wolk
Summary: Hidradenitis suppurativa (HS) is a chronic, disabling, and debilitating inflammatory disease with limited treatment options. The pathophysiology of HS is not fully understood, but TNF-alpha and IL-17 pathways play important roles. Currently, multiple promising therapeutic targets are being explored.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stephen L. Bearne, Chen-Jun Guo, Ji-Long Liu
Summary: Cytidine-5'-triphosphate synthase (CTPS) is an enzyme involved in the biosynthesis of CTP. It requires an allosteric effector (GTP) to activate the glutamine hydrolysis process and also plays a role in the assembly and maintenance of the NH3 tunnel.
Review
Biochemistry & Molecular Biology
Li Li, Rui Ni, Ziwei Li, Yue Ming, Li Liu, Dan Peng, Yongqing Cai, Yuanlin Wu, Tingting Jiang, Yanping Li, Yao Liu
Summary: This review summarizes the regulatory factors involved in the process of platelet formation, including cytokines, growth factors, transcription factors, and gene expression, as well as the roles of the TPO/Mpl signaling pathway, RasGTPases family, estrogen, and microRNAs. Understanding these molecular mechanisms contributes to a better understanding of megakaryocyte differentiation and platelet formation.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Chemistry, Physical
Guanjun Chen, Jinheng Ma, Junxuan Zhang, Ying Lin, Tong Wang, Yan Cheng, Haibo Yang, Fei Ma
Summary: A ternary hybrid consisting of Pt nanocrystals, ultrathin nanoflower-like nickel carbonate hydroxide (NiCH) and porous carbon is designed to improve the operational durability of Pt-based anodic electrocatalysts in direct methanol fuel cells (DMFCs). The NiCH facilitates CO poisoning removal by dissociating water molecules and accelerating charge transfer, while porous carbon offsets the poor conductivity of NiCH. The hybrid catalyst demonstrates high stability, retaining over 39% of its initial activity after 5000 s of testing and experiencing only a 25% reduction in peak current after 8000 CV cycles. This work provides a promising candidate for the design of DMFCs anodic electrocatalysts.
APPLIED SURFACE SCIENCE
(2023)