Review
Oncology
Zahra Sadat Razavi, Vida Tajiknia, Shahab Majidi, Maryam Ghandali, Hamid Reza Mirzaei, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: Gynecologic cancers involve female genital organs and are influenced by personal lifestyle, exposure history, genetics, and other factors. Research has shown that non-coding RNAs play a significant role in the regulation of cellular function in gynecological cancer, potentially leading to new avenues for diagnosis and treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiong Piao, Lie Ma, Qinqi Xu, Xiaomin Zhang, Chengzhu Jin
Summary: Noncoding RNAs play versatile roles in the regulation of endothelial dysfunction in atherosclerosis, including inflammation, migration, proliferation, and apoptosis. Understanding these regulatory roles may lead to the development of novel therapeutic strategies.
Review
Cell Biology
Elzbieta Wanowska, Klaudia Samorowska, Michal Wojciech Szczesniak
Summary: Breast carcinogenesis involves genetic and epigenetic changes. Dysregulated epigenetic changes in breast cancer are accompanied by epitranscriptomic changes within RNA molecules. Long noncoding RNAs (lncRNAs) participate in various aspects of breast cancer biology and hold potential as biomarkers and therapeutic targets. However, the medical application of lncRNAs still faces challenges.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Wangkai Xie, Man Chu, Gendi Song, Ziyi Zuo, Zheng Han, Chenbin Chen, Yuyun Li, Zhi-wei Wang
Summary: Pancreatic cancer is a leading cause of cancer death worldwide due to its lack of early symptoms, metastasis, and chemoresistance. This review article summarizes the role of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in modulating chemosensitivity in pancreatic cancer cells. It also highlights the potential compounds that can modulate the expression of lncRNAs and enhance chemosensitivity in pancreatic cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Qiang Liu
Summary: Long noncoding RNAs (LncRNAs) are gene expression regulatory elements that play important roles in the occurrence and development of Wilms tumor (WT). They have the potential to become novel biomarkers for the diagnosis and treatment of WT, providing new directions for clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sarva Keihani, Verena Kluever, Eugenio F. Fornasiero
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in regulating neurogenesis, neuronal differentiation, and excitability, making them potential biomarkers for brain diseases due to their diversity and association with neurodegenerative diseases. Further investigation into lncRNA functions is essential for a comprehensive understanding of neuronal pathophysiology in the future.
Review
Cell Biology
Olivia Arnold, Karina Barbosa, Aniruddha J. Deshpande, Nan Zhu
Summary: DOT1L plays a crucial role in normal and malignant hematopoiesis, and its aberrant activity is implicated in the development of hematopoietic malignancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aboo Shabna, Sadanandhan Bindhya, Chirukandath Sidhanth, Manoj Garg, Trivadi S. Ganesan
Summary: Cancer stem cells (CSCs) or tumor-initiating cells contribute to drug resistance, metastasis, and aggressiveness in cancer. The identification and understanding of long non-coding RNAs (lncRNAs) specific to CSCs can provide potential targets for drug development. This review focuses on lncRNAs with strong functional evidence for CSC specificity and their mechanistic role in regulating and maintaining CSCs, highlighting the challenges and methods involved in identifying these specific lncRNAs.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Cell Biology
Paola Ruffo, Francesca De Amicis, Emiliano Giardina, Francesca Luisa Conforti
Summary: The development of high-throughput sequencing technologies has greatly enhanced our understanding of gene expression regulation. Editing the epigenome and epitranscriptome can influence the fate and function of mRNA, with non-coding RNAs playing a crucial role in this regulation. Long non-coding RNAs have been found to act as epigenetic regulators in neurodegenerative disorders, and their dysregulation may contribute to neuronal degeneration through RNA modifications. Exploring the diagnostic and therapeutic potential of long non-coding RNAs could lead to novel treatments for these incurable diseases.
NEURAL REGENERATION RESEARCH
(2023)
Review
Oncology
Xia Wu, Wu Ye, Yuping Gong
Summary: METTL3 is a core methyltransferase involved in m(6)A modification and plays a vital role in normal and malignant hematopoiesis. It affects the differentiation, apoptosis, proliferation, chemoresistance, and risk of tumors in hematological neoplasms. Inhibitors of METTL3, such as STM2457, have shown potential in treating acute myeloid leukemia by blocking proliferation and promoting differentiation and apoptosis of cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitham G. Abo-Al-Ela
Summary: ncRNAs play crucial roles in regulating and controlling cellular processes and trafficking pathways, with lncRNAs having more diverse regulatory functions compared to microRNAs. Studies in fish have highlighted the potential of harnessing these RNA types to further understand biology and utilize technologies such as RNA interference and microRNA delivery for applications in aquaculture productivity, fish health, and overall understanding of fish biology.
MOLECULAR GENETICS AND GENOMICS
(2021)
Review
Biochemistry & Molecular Biology
Ioanna E. Stergiou, Efstathia K. Kapsogeorgou
Summary: The hematopoietic system relies on the regulation of both metabolism and autophagy to maintain homeostasis, especially for the self-renewal and differentiation potential of hematopoietic stem cells. Metabolic rewiring from glycolysis to oxidative phosphorylation is crucial for effective hematopoietic differentiation. Autophagy plays a role in modulating the characteristics of quiescent and differentiating hematopoietic cells, with mitophagy impacting the cellular mitochondrial content and energy levels for differentiation. Aberrations in metabolic status and autophagic regulation are implicated in hematologic malignancies, particularly in leukemogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Mehdi Alidadi, Ahmed Hjazi, Irfan Ahmad, Reza Mahmoudi, Masoud Sarrafha, Seyed Reza Hosseini-Fard, Mohammadreza Ebrahimzade
Summary: Atherosclerosis is a disease caused by LDL and inflammation, which affects the sub-endothelial space. Various factors, including inflammation, LDL oxidation, endothelial dysfunction, foam cell formation, and smooth muscle cell proliferation and migration, are involved in the pathogenesis of atherosclerosis. Crosstalk among atherosclerosis-induced cells plays an important role in modulating the disease. Exosomes, a type of extracellular vesicle, have been found to carry bioactive components like proteins, lipids, RNA, and DNA, and can affect the communication between sub-endothelial cells. Noncoding RNAs, such as microRNAs, long noncoding RNAs, and circular RNAs, which are important cargo in exosomes, can regulate cellular functions. This study aims to investigate the molecular mechanisms of exosomal ncRNAs and their potential as diagnostic biomarkers and therapeutic targets in atherosclerosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Yajie Liao, Xudong Wu, Mengyu Wu, Yuan Fang, Jie Li, Weiqiang Tang
Summary: Lung cancer is the second most common cancer globally and the leading cause of tumor-related mortality. Angiogenesis, a critical feature in cancer development, is a promising target for lung cancer treatment. Non-coding RNAs (ncRNAs) have been found to play crucial roles in tumor angiogenesis, and this review focuses on discussing the regulatory functions of different ncRNAs in lung cancer angiogenesis, including downstream targets and signaling pathways. The potential applications of ncRNAs as biomarkers or novel anti-angiogenic tools in lung cancer are also explored.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Pengbo Cao, Qian Jin, Lan Feng, Haibei Li, Geng Qin, Gangqiao Zhou
Summary: The article introduces the roles of noncoding RNA (ncRNA) in hepatocellular carcinoma (HCC) and their potential clinical applications in cancer diagnosis and treatment, highlighting ncRNAs as potential novel biomarkers for cancer.
SEMINARS IN CANCER BIOLOGY
(2021)