Article
Oncology
Julieta Leone, Rachel A. Freedman, Nancy U. Lin, Sara M. Tolaney, Carlos T. Vallejo, Bernardo A. Leone, Eric P. Winer, Jose Pablo Leone
Summary: This study revealed significant differences in survival outcomes by tumor subtype among male breast cancer patients. Specifically, triple-negative tumor subtype had the worst survival outcomes. Stage, tumor subtype, and race were found to be significantly associated with overall survival and breast cancer-specific survival.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Multidisciplinary Sciences
Karama Asleh, Gian Luca Negri, Sandra E. Spencer Miko, Shane Colborne, Christopher S. Hughes, Xiu Q. Wang, Dongxia Gao, C. Blake Gilks, Stephen K. L. Chia, Torsten O. Nielsen, Gregg B. Morin
Summary: Proteomic analysis of breast cancer surgical specimens identifies distinct subtypes, immune features, and survival outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Joel S. Parker, Michael Mullins, Maggie C. U. Cheang, Samuel Leung, David Voduc, Tammi Vickery, Sherri Davies, Christiane Fauron, Xiaping He, Zhiyuan Hu, John F. Quackenbush, Inge J. Stijleman, Juan Palazzo, J. S. Marron, Andrew B. Nobel, Elaine Mardis, Torsten O. Nielsen, Matthew J. Ellis, Charles M. Perou, Philip S. Bernard
Summary: This study developed a risk model that incorporates gene expression-based intrinsic subtypes for breast cancer prognosis and prediction of chemotherapy benefit. The intrinsic subtypes showed significant prognostic significance and remained significant even when standard parameters were incorporated. The model can be used to predict prognosis for node-negative breast cancer and assess the likelihood of efficacy from neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Gedmante Radziuviene, Allan Rasmusson, Renaldas Augulis, Ruta Barbora Grineviciute, Dovile Zilenaite, Aida Laurinaviciene, Valerijus Ostapenko, Arvydas Laurinavicius
Summary: This study established prognostic models for overall survival of HER2 IHC 2+ breast cancer patients, taking into account spatial aspects of intratumoral heterogeneity and tumor microenvironment. Different factors were found to have independent predictive value for patient survival, with the spatial distribution of CD8 cells in the tumor microenvironment playing a crucial role in prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Masanori Oshi, Shipra Gandhi, Yoshihisa Tokumaru, Li Yan, Akimitsu Yamada, Ryusei Matsuyama, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
Summary: In ER-positive/HER2-negative breast cancer, high EGFR expression is associated with improved survival and an anti-cancer immune microenvironment; conversely, TNBC with higher EGFR expression has lower immune cell infiltration.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Jutta Engel, Renate Eckel, Kathrin Halfter, Gabriele Schubert-Fritschle, Dieter Hoelzel
Summary: Through analysis of patient data, key time periods and factors for primary breast cancer and metastasis were identified. The study results suggest that the growth period of breast cancer is 12.5 years, metastasis occurs approximately 8.8 years after diagnosis, local recurrences happen around 5 years, and regional lymph node metastasis occurs after 3.5 years. Based on these findings, principles for the metastasis process and adjuvant treatments were proposed, including 50% eradication of primary breast cancer and selective and partial eradication of bone and lung metastases.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Analytical
Mengjia Hu, Virginia Brown, Joshua M. Jackson, Harshani Wijerathne, Harsh Pathak, Devin C. Koestler, Emily Nissen, Mateusz L. Hupert, Rolf Muller, Andrew K. Godwin, Malgorzata A. Witek, Steven A. Soper
Summary: Extracellular vesicles (EVs) have the potential to be used as a minimally invasive liquid biopsy marker for precision medicine, as they carry RNA cargo associated with the cell-of-origin. Researchers have developed an EV microfluidic affinity purification (EV-MAP) chip, made from plastic for high-scale production, which can isolate EV subpopulations. They demonstrated the utility of this chip in molecular subtyping breast cancer patients, isolating two subpopulations of EVs that better recapitulate the tumor microenvironment. The EV-MAP provided high recovery and specificity based on exosomal mRNA and PCR results, and the EV subpopulations showed potential for prognostication using the PAM50 test.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Manuela Gago-Dominguez, Carmen M. Redondo, Manuel Calaza, Marcos Matabuena, Maria A. Bermudez, Roman Perez-Fernandez, Maria Torres-Espanol, Angel Carracedo, J. Esteban Castelao
Summary: The study revealed an association between LIPG and breast cancer, particularly in specific conditions including pre-menopausal breast cancer, Luminal A breast cancers, HER2-negative breast cancers, women with high total cholesterol levels, non-postpartum breast cancer, and grades II and III breast cancers.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Galia Jacobson, Orit Kaidar-Person, Ory Haisraely, Shira Galper, Tatiana Rabin, Ilanit Dromi Shahadi, Yaacov Richard Lawrence, Zvi Symon, Merav Akiva Ben-David
Summary: Both single fraction and fractionated radiation therapy were effective for palliative treatment, with fractionated therapy showing a more durable response. As a result of equivalent palliative outcomes, there has been an increasing trend towards using single fraction radiation therapy for palliation during the COVID-19 pandemic.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Nikita Kotlov, Alexander Bagaev, Maria Revuelta, Jude M. Phillip, Maria Teresa Cacciapuoti, Zoya Antysheva, Viktor Svekolkin, Ekaterina Tikhonova, Natalia Miheecheva, Natalia Kuzkina, Grigorii Nos, Fabrizio Tabbo, Felix Frenkel, Paola Ghione, Maria Tsiper, Nava Almog, Nathan Fowler, Ari M. Melnick, John P. Leonard, Giorgio Inghirami, Leandro Cerchietti
Summary: In this study, a transcriptomic analysis of the microenvironment of DLBCL was conducted, revealing four major lymphoma microenvironment categories associated with distinct biological aberrations and clinical behavior. This research also identified genetic and epigenetic mechanisms used by cancer cells to evade microenvironmental constraints and suggested the use of DNA hypomethylating agents in selected DLBCL patients. Additionally, new therapeutic vulnerabilities in the extracellular matrix composition were uncovered, providing potential targets for decreasing DLBCL proliferation in preclinical models.
Article
Genetics & Heredity
Shenting Liu, He Xu, Ying Feng, Ulf D. Kahlert, Renfei Du, Luz Angela Torres-de la Roche, Kai Xu, Wenjie Shi, Fanshuai Meng
Summary: Based on the analysis of TNBC samples, we identified two subtypes (A and B) related to oxidative stress, with subtype A showing better prognosis. Subtype A exhibited higher immune infiltration characteristics, with tumor-suppressive immune cells, HLA genes, and three immune inhibitors being more prevalent. We also developed an eight-gene signature as an independent risk factor for TNBC and validated its predictive value. Our study reveals distinct molecular clusters based on OS-related genes, providing insights into the ROS-mediated progression and crosstalk with the tumor microenvironment in TNBC, and offering a risk prognostic model for clinical treatment decisions.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Anne Marie McCarthy, Tara Friebel-Klingner, Sarah Ehsan, Wei He, Michaela Welch, Jinbo Chen, Despina Kontos, Susan M. Domchek, Emily F. Conant, Alan Semine, Kevin Hughes, Aditya Bardia, Constance Lehman, Katrina Armstrong
Summary: Breast cancer is a heterogeneous disease with different subtypes based on ER, PR, and HER2 expression. This study found that Black women had 2.7 times higher risk of TNBC compared to white women, breast density and BMI were associated with different subtypes, and TNBC was more likely to be interval cancer.
Article
Biochemistry & Molecular Biology
Lyudmila Bel'skaya, Elena A. Sarf
Summary: The aim of this study was to determine the metabolic characteristics of saliva based on the molecular biological subtype of breast cancer and the expression levels of HER2, estrogen receptors (ER), and progesterone receptors (PR). The study found that saliva samples from healthy volunteers and patients with different molecular biological subtypes of breast cancer showed differences in 12 biochemical indicators. The composition of saliva in patients with basal-like breast cancer differed the most from other subtypes, indicating a more severe disease and less favorable prognosis. The study also analyzed the individual contribution of HER2, estrogen, and progesterone receptors to changes in saliva composition, finding significant differences compared to a control group.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Oncology
Jhajaira M. Araujo, Gabriel De la Cruz-Ku, Melanie Cornejo, Franco Doimi, Richard Dyer, Henry L. Gomez, Joseph A. Pinto
Summary: This study evaluated the prognostic capability of a 3-gene score in different subtypes of triple negative breast cancer (TNBC). The results showed that the score was able to predict the risk of distant recurrence in the immunomodulatory and mesenchymal stem-like subtypes. Additionally, a low score was associated with a high level of tumor-infiltrating lymphocytes.
Article
Oncology
Quentin Klopfenstein, Valentin Derangere, Laurent Arnould, Marion Thibaudin, Emeric Limagne, Francois Ghiringhelli, Caroline Truntzer, Sylvain Ladoire
Summary: The prognosis of early breast cancer is associated with the clinic-pathological stage and the molecular characteristics of tumor cells. In some patients, the presence of tumor-infiltrating immune cells can impact long term outcome. A new gene expression deconvolution algorithm was developed to estimate immune cell populations in tumors and found that myeloid cells were associated with poor outcomes, while lymphoid cells were linked to favorable prognosis. This information, when combined with clinical stage and PAM50, can improve the prediction of relapse or death in early breast cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Sport Sciences
Moritz T. Winkelmann, Leonard Achenbach, Florian Zeman, Lior Laver, Sven S. Walter
Summary: The anterior and inferior capsule thicknesses in youth elite handball athletes do not differ significantly or only marginally between throwing and non-throwing shoulders.
RESEARCH IN SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Wester, Franziska Koll, Mark Luedde, Christoph Langer, Markus Resch, Andreas Luchner, Karolina Mueller, Florian Zeman, Michael Koller, Lars S. Maier, Samuel Sossalla
Summary: This study assessed the impact of percutaneous coronary intervention (PCI) on dyspnea, quality of life, and angina pectoris in patients with stable coronary artery disease (CAD). The results showed that PCI effectively reduced the symptomatic burden of angina pectoris and dyspnea. However, patients with concomitant dyspnea had worse physical limitation scores, angina frequency, and quality of life after PCI.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bernadett Kurz, Hannah Philine Michael, Antonia Foerch, Susanne Wallner, Florian Zeman, Sonja-Maria Decking, Ines Ugele, Constantin Hintschich, Frank Haubner, Tobias Ettl, Kathrin Renner, Christoph Brochhausen, Stephan Schreml
Summary: TRPCs are important in tumor biology, particularly in Ca2+ homeostasis in cancer cells. TRPC4, a pH-sensitive protein, may function as a signaling molecule in the altered tumor microenvironment due to the reversed pH-gradient in solid tumors. The study investigated TRPC4 expression profiles in common skin cancers, revealing that SCC, NCN, and MM show positive TRPC4-expression, while BCC only does so in about half of the analyzed samples. This finding suggests TRPC4 as an immunohistochemical marker to distinguish SCC and BCC and warrants further research on its role in tumor progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Isabella Gruber, Oliver Koelbl, Marius Treutwein, Florian Zeman, Wolfgang Herr, Ernst Holler, Matthias Edinger, Daniel Wolff
Summary: This study compared the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients with acute myeloid leukemia who received total body irradiation (TBI)-based conditioning or non-TBI-based conditioning. The results showed that both TBI and non-TBI conditioning had similar effects on non-relapse mortality, relapse incidence, and overall survival. The study suggests that both conditioning methods are equally effective and well-tolerated for eligible AML patients undergoing their first allo-HSCT.
ANNALS OF HEMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
J. Weber, L. Henssler, F. Zeman, C. Pfeifer, V. Alt, M. Nerlich, M. Huber, T. Herbst, M. Koller, W. Schneider-Brachert, M. Kerschbaum, T. Holzmann
Summary: This study investigated the efficacy of a newly developed antimicrobial coating containing nanosilver in long-term reduction of bacterial load on hospital surfaces. The results showed that the nanosilver-containing coating significantly reduced bacterial contamination and load. This study demonstrates the effectiveness of nanosilver antimicrobial coating in reducing bacterial colonization on frequently touched surfaces in a clinical setting.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Medicine, General & Internal
Philipp von Breitenbuch, Bernadett Kurz, Susanne Wallner, Florian Zeman, Christoph Brochhausen, Hans-Juergen Schlitt, Stephan Schreml
Summary: Solid tumors have a unique metabolism that affects their pH gradient and signaling mechanisms. A study on peritoneal carcinomatosis found lower expression of GPR4 and GPR68, pH-GPCRs, compared to other pH-GPCRs, which could potentially be targeted for future therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sebastian Blecha, Anna Hager, Verena Gross, Timo Seyfried, Florian Zeman, Matthias Lubnow, Maximilian Burger, Michael T. Pawlik
Summary: The aim of this study was to evaluate whether crystalloid administration and individual management of positive end-expiratory pressure (PEEP) improve peri- and post-operative pulmonary function in patients undergoing robotic-assisted laparoscopic prostatectomy (RALP). The results showed that individualized high PEEP levels improved intraoperative blood oxygenation and resulted in more lung-protective ventilation. Furthermore, postoperative pulmonary function was improved for up to 48 h after surgery. Restrictive crystalloid infusion seemed to have no effect on peri- and post-operative oxygenation and pulmonary function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Konstantin Drexler, Hans Drexler, Sigrid Karrer, Michael Landthaler, Sebastian Haferkamp, Florian Zeman, Mark Berneburg, Dennis Niebel
Summary: This study compared the degree of actinic elastosis in different types of keratinocyte cancer and found that chronic UV exposure is more strongly associated with cutaneous squamous cell carcinoma (cSCC) compared to basal cell carcinoma (BCC), regardless of age, sex, body site, and tumor subtypes.
Article
Orthopedics
Julia Goetz, Guenther Maderbacher, Anna Gerg, Franziska Leiss, Silvia Dullien, Florian Zeman, Matthias Meyer, Jan Reinhard, Joachim Grifka, Felix Greimel
Summary: The study aimed to compare the isokinetic quadriceps muscle strength after cemented TKA with enhanced recovery after surgery (ERAS) and conventional setup. The ERAS group showed significantly better knee flexion isokinetic muscle strength 5 days postoperatively, but no significant difference was observed between the two groups after 4 weeks. In conclusion, TKA with ERAS improves isokinetic outcomes and patient satisfaction, and isokinetic muscle strength measurement can help modify expectations and improve patient satisfaction.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2023)
Meeting Abstract
Critical Care Medicine
M. Arzt, H. Fox, S. Stadler, A. Hetzenecker, O. Hamer, F. Poschenrieder, C. Wiest, R. Tanacli, S. Kelle, L. Bruch, M. Seidel, M. Koller, F. Zeman, S. Buchner
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Orthopedics
Julia Goetz, Guenther Maderbacher, Franziska Leiss, Florian Zeman, Matthias Meyer, Jan Reinhard, Joachim Grifka, Felix Greimel
Summary: A study with 194 patients found that patients who underwent total hip arthroplasty (THA) using an enhanced recovery after surgery (ERAS) program showed better postoperative mobility and pain reduction compared to those in a conventional setup group, with no complications recorded. Thus, ERAS could be applied in clinical practice.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Geriatrics & Gerontology
Christina Kaufmann, Nina Zech, Florian Brandt, Michael Hilker, Kurt Debl, Marcus Creutzenberg, Florian Zeman, Bernhard M. M. Graf, Barbara Sinner
Summary: This study aimed to investigate the effect of intraoperative music and positive suggestions on postoperative delirium (POD) in elderly patients undergoing transcatheter aortic valve replacement (TAVR) surgery. The results showed that intraoperative music and positive suggestions had no impact on the incidence of POD, pain, analgesic requirement, or postoperative nausea and vomiting (PONV).
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Correction
Oncology
Niklas Verloh, Isabel Jensch, Lukas Luerken, Michael Haimerl, Marco Dollinger, Philipp Renner, Philipp Wiggermann, Jens Martin Werner, Florian Zeman, Christian Stroszczynski, Lukas Philipp Beyer
RADIOLOGY AND ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Meindl, Michael Paulus, Florian Poschenrieder, Okka W. Hamer, Florian Zeman, Lars S. Maier, Kurt Debl
Summary: This study investigated the diagnostic value of speckle tracking echocardiography in patients with acute myocarditis and normal left ventricular ejection fraction (LVEF). The results showed that patients with acute myocarditis had impaired left ventricular and left atrial function compared to healthy controls, despite preserved LVEF. This suggests that ventricular diastolic dysfunction and elevated LV filling pressures may be present in these patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonia-Maria Pausch, Tamam Ghali, Tobias Wertheimer, Florian Zeman, Karolina Mueller, Michael Christian Doppler, Ingo Einspieler, Lukas Philipp Beyer, Stephan Schleder, Christian Stroszczynski, Lukas Luerken
Summary: This study aimed to evaluate the influence of minimal ablative margin (MAM) and initial tumor size on the success of stereotactic MWA of HCC. The results showed that the maximum tumor diameter was a significant predictor for LTP, while MAM did not have a significant influence on LTP-free survival and OS.
