Process development exploiting competitive adsorption‐based displacement effects in monoclonal antibody aggregate removal—A new high‐throughput screening procedure for membrane chromatography

Displacement to separate host‐cell proteins and aggregates in cation‐exchange chromatography of monoclonal antibodies

(2020) Ohnmar Khanal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling

(2019) Steven W. Benner et al.   JOURNAL OF CHROMATOGRAPHY A

Cation exchange frontal chromatography for the removal of monoclonal antibody aggregates

(2019) Matthew T. Stone et al.   JOURNAL OF CHROMATOGRAPHY A

Integrated flow-through purification for therapeutic monoclonal antibodies processing

(2018) Takamitsu Ichihara et al.   mAbs

Multi-column displacement chromatography for separation of charge variants of monoclonal antibodies

(2018) Ohnmar Khanal et al.   JOURNAL OF CHROMATOGRAPHY A

Understanding operational system differences for transfer of miniaturized chromatography column data using simulations

(2017) William R. Keller et al.   JOURNAL OF CHROMATOGRAPHY A

Separation of antibody monomer-dimer mixtures by frontal analysis

(2017) Jason M. Reck et al.   JOURNAL OF CHROMATOGRAPHY A

Use of MiniColumns for linear isotherm parameter estimation and prediction of benchtop column performance

(2015) William R. Keller et al.   JOURNAL OF CHROMATOGRAPHY A

Automated disposable small scale reactor for high throughput bioprocess development: A proof of concept study

(2013) Rachel Bareither et al.   BIOTECHNOLOGY AND BIOENGINEERING

Determination of parameters for the steric mass action model—A comparison between two approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

Aggregates in monoclonal antibody manufacturing processes

(2011) María Vázquez-Rey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Designing new monoclonal antibody purification processes using mixed-mode chromatography sorbents

(2011) Magali Toueille et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Overloading ion-exchange membranes as a purification step for monoclonal antibodies

(2010) Arick Brown et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Protein aggregation—Pathways and influencing factors

(2010) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Application of mixed mode resins for the purification of antibodies

(2010) Agnes Voitl et al.   JOURNAL OF CHROMATOGRAPHY A

Selectivity of monolithic supports under overloading conditions and their use for separation of human plasma and isolation of low abundance proteins

(2010) Marija Brgles et al.   JOURNAL OF CHROMATOGRAPHY A

Recovery and purification process development for monoclonal antibody production

(2010) Hui F. Liu et al.   mAbs

Development of a polishing step using a hydrophobic interaction membrane adsorber with a PER.C6®-derived recombinant antibody

(2009) Michael Kuczewski et al.   BIOTECHNOLOGY AND BIOENGINEERING

High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

(2008) M. Wiendahl et al.   CHEMICAL ENGINEERING & TECHNOLOGY