Article
Engineering, Biomedical
Cheung Kwan Yeung, Yaping Yan, Li Yan, Yanchao Duan, Enqin Li, Borong Huang, Ke Lu, Koukou Li, Muya Zhou, Lei Zhang, Yaojiong Wu, Kathy Qian Luo, Weizhi Ji, Ren-He Xu, Wei Si
Summary: Previous research has shown that locally-administered MSCsp can promote wound healing and alleviate multiple sclerosis and osteoarthritis, while intravenous injection of MSCsp in cynomolgus monkeys has been found to be feasible, safe, and potentially associated with better efficacy.
Article
Nanoscience & Nanotechnology
Tiep Tien Nguyen, Mai Thi Phuong, Manju Shrestha, Junhyeung Park, Pham Le Minh, Jong Oh Kim, Hyukjae Choi, Joo-Won Nam, Hu-Lin Jiang, Hyung-Sik Kim, Jee-Heon Jeong, Jun-Beom Park, Simmyung Yook
Summary: Potentiation of stem cell potency is crucial for successful bone regeneration in tissue engineering. This study demonstrates a uniform and scalable method to fabricate osteogenic microtissue constructs of mesenchymal stem cell (MSC) spheroids surface-engineered with dexamethasone-releasing polydopamine-coated microparticles (PD-DEXA/MPs). The incorporation of DEXA significantly enhances the osteogenic differentiation of MSC spheroids, and the microparticles remain stable during cell migration. Implantation of these constructs in a mouse model shows substantial bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Electrochemistry
Kaoru Hiramoto, Keika Komatsu, Ryota Shikuwa, An Konno, Yusuke Sato, Ayumi Hirano-Iwata, Kosuke Ino, Hitoshi Shiku
Summary: Multicellular spheroids are important models in vitro for studying biological and pathological processes. Monitoring their cellular activities without labeling is challenging, but electrochemiluminescence (ECL) has the potential to track the activities of spheroids by displaying secreted molecules adhering to an electrode.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Wenjin Liang, Min Wang, Chaoyun Ma, Jiawen Wang, Chulei Zhao, Chenglin Hong
Summary: In this study, the use of nickel-cobalt layered double hydroxide hollow nanocages was found to enhance the electrochemiluminescence emission in the luminol co-reactant system, leading to sensitive detection and analysis of alpha-fetoprotein.
Article
Materials Science, Multidisciplinary
Elena Villani, Yanyun Zhang, Zhenghao Chen, Yaqian Zhou, Mariko Konishi, Ikuyoshi Tomita, Shinsuke Inagi
Summary: In this study, we developed poly(3,4-ethylenedioxythiophene)(PEDOT) thin films and their composites, such as PEDOT-copper (PEDOT-Cu) and PEDOT-polythiophene (PEDOT-PT), on a nonconductive substrate using AC-bipolar electropolymerization. These films were then utilized as wireless electrodes for the generation of luminol electrochemiluminescence (ECL). The intensity and spatial distribution of the ECL light emission were found to be correlated with the conductivity and composition of the different polymer films.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Chemical
JunHwee Jang, Eun-Jung Lee
Summary: Cell spheroids have been studied as a biomimetic medicine for tissue healing, with rapid production using MXene particles, inducing spheroid formation within 6 hours at concentrations of 1 to 10 mu g/mL. Osteogenic differentiation behavior was observed with the highest activity levels at a concentration of 5 mu g/mL, showing an effective method for rapid formation of stem cell spheroids using MXene.
Article
Biochemistry & Molecular Biology
Viktoria Pevna, Mariana Macajova, Andrej Hovan, Gregor Bano, Majlinda Meta, Boris Bilcik, Julia Palkova, Veronika Huntosova
Summary: This study used spheroid models to simulate tumor tissue and demonstrated the reliability and applicability of these models in studying the response and effects of photodynamic therapy (PDT). The findings are important for further research in PDT.
Review
Medicine, Research & Experimental
Ali Hazrati, Kosar Malekpour, Sara Soudi, Seyed Mahmoud Hashemi
Summary: Cell therapy, specifically mesenchymal stem/stromal cell (MSCs) transplantation, has emerged as a new treatment method with therapeutic efficacy proven in clinical applications. MSCs exert their therapeutic functions through various mechanisms such as differentiation potential, immunomodulatory properties, production of therapeutic exosomes, growth factors and cytokines, and anti-apoptotic effects. However, limitations in exosome production and therapeutic ability have prompted researchers to explore methods that enhance the therapeutic potential of exosomes, such as MSCs cultured in spheroids. This review discusses the enhanced properties of MSCs and their exosomes in spheroid culture.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Biomedical
Gyunggyu Lee, Hyemin Kim, Ji Young Park, Gyeongmin Kim, Jiyou Han, Seok Chung, Ji Hun Yang, Jang Su Jeon, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim
Summary: Advances in pluripotent stem cell technology have led to the efficient and reproducible generation of hepatocyte-like cell spheroids in various sizes using microwell culture platforms. These spheroids show high expressions of hepatic marker genes, enhanced drug-metabolizing activity, and increased sensitivity to hepatotoxicants compared to traditional hepatocytes. This imaging-based toxicity screening system holds promise for predicting drug-induced hepatotoxicity in the early stages of drug discovery.
Article
Chemistry, Multidisciplinary
Ming-Ming Chen, Cong-Hui Xu, Wei Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: We report a photodynamic therapy driven by electrochemiluminescence (ECL) with potential clinical applications. The ECL-generated luminescence acts as both optical readout and light source for the excitation of photosensitizer to produce reactive oxygen species (ROS). Real-time monitoring of cellular processes during ECL-PDT was achieved using ECL microscopy with high spatiotemporal resolution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Agriculture, Dairy & Animal Science
Ga Yeon Kim, Gyu Tae Choi, Jinryong Park, Jeongeun Lee, Jeong Tae Do
Summary: In this study, two types of porcine MSCs were compared, and it was found that adipose-derived stem cells showed better proliferation capacity, adipogenic and chondrogenic differentiation potential, and mitochondrial metabolism compared to Wharton's jelly-derived mesenchymal stem cells. This study provides insights into the characteristics of porcine MSCs and their potential applications in animal clinics and cultured meat science.
Article
Chemistry, Analytical
Huairong Zhang, Yong Liu, Mei Yao, Wenxiu Han, Shusheng Zhang
Summary: Cathodic electrochemiluminesence (ECL) microscopy based on luminol analog L012 utilizes multiwalled carbon nanotubes (MWCNTs) as coreactant accelerators to convert oxygen and H2O2 into reactive oxygen species. The produced ROS oxidizes L012 to emit bright cathodic ECL illumination, enabling the imaging of nanotubes and nucleolin on tumor cells. By modifying MWCNTs with AS1411 aptamers, label-free ECL imaging of nucleolin on plasma membranes was achieved, providing a universal approach in single nanomaterial and single-cell imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eun Mi Kim, Gyeong Min Lee, Sangmin Lee, Se-jeong Kim, Dongtak Lee, Dae Sung Yoon, Jinmyoung Joo, Hyunjoon Kong, Hee Ho Park, Heungsoo Shin
Summary: This study investigated the impact of encapsulating stem cell spheroids in hydrogels with varying concentrations of gelatin methacryloyl on stem cell functions. Results showed that the mechanical properties of the hydrogel can regulate the functionality of spheroids, suggesting their suitability for use in 3D tissue construction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Wan-Kyu Ko, Daye Lee, Seong Jun Kim, Gong Ho Han, Donghyun Lee, Seung Hun Sheen, Seil Sohn
Summary: This study aimed to develop a biocompatible treatment using an injectable hydrogel containing PMMA to overcome the limitations of PMMA vertebroplasty for osteoporotic compression fracture patients. MSC spheroids were included in the gel to investigate their osteogenic/anti-inflammatory effects in vitro, and the pain-relief effects were investigated in ovariectomy-induced osteoporotic rats with injured femurs. The results showed that the PMMA-doped spheroid gel had positive effects on osteogenesis and pain relief, suggesting its potential usefulness for osteoporotic vertebral compression fracture patients.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Junshuai Xue, Nianfeng Sun, Yang Liu
Summary: This study presents a novel and effective approach to accelerate diabetic skin wound healing. The researchers shaped human umbilical cord mesenchymal stem cells (hUC-MSCs) into spheres and combined them with nanopeptide hydrogels for transplantation into a mouse model. The results demonstrated that this approach significantly accelerated wound healing and promoted angiogenesis by inhibiting inflammation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Electrochemistry
Kosuke Ino, Keika Komatsu, Kaoru Hiramoto, Yoshinobu Utagawa, Yuji Nashimoto, Hitoshi Shiku
Summary: This study presents a method for electrochemiluminescence (ECL) imaging to visualize cellular adhesion on hydrogel scaffolds. By culturing human umbilical vein endothelial cells on a Matrigel-coated indium tin oxide (ITO) electrode and using an ECL solution and specific voltage, ECL signals were generated, allowing for imaging of cellular adhesion.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Yoshinobu Utagawa, Kosuke Ino, Tatsuki Kumagai, Kaoru Hiramoto, Masahiro Takinoue, Yuji Nashimoto, Hitoshi Shiku
Summary: A novel electrochemical strategy for gluing hydrogel fibers is presented in this study. The method involves using microelectrodes to generate chemicals for crosslinking the fibers. The results show that the electrochemical glue is non-toxic to cells, making it a promising method for tissue engineering and organ-on-a-chip development.
Editorial Material
Chemistry, Analytical
Kosuke Ino
Article
Biophysics
Yuji Nashimoto, Rei Mukomoto, Takuto Imaizumi, Takato Terai, Shotaro Shishido, Kosuke Ino, Ryuji Yokokawa, Takashi Miura, Kunishige Onuma, Masahiro Inoue, Hitoshi Shiku
Summary: Microphysiological systems (MPSs) with three-dimensional (3D) cultured models have the potential to mimic human health and disease conditions. This study designed a microfluidic device with sensor capabilities to analyze oxygen metabolism in vascularized 3D tissue models. The platform was able to integrate a perfusable vascular network with 3D cultured cells and monitor changes in oxygen metabolism in a quantitative, non-invasive, and real-time manner.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemical Research Methods
Kazuya Fujimoto, Scott Erickson, Masamune Nakayama, Hiroki Ihara, Kei Sugihara, Yuji Nashimoto, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa
Summary: Blood vessel morphology is influenced by mechanical and biochemical cues, such as flow-induced shear stress and pericytes. This study reveals that angiogenesis occurs at locations with relatively low shear stresses (0.5-1.5 dyn cm(-2)) and that pericytes regulate vascular diameter. Furthermore, inhibiting platelet-derived growth factor receptor beta decreases pericyte coverage without affecting vessel diameter.
Article
Chemistry, Analytical
Kentaro Ito, Kumi Y. Inoue, Takahiro Ito-Sasaki, Miho Ikegawa, Shinichiro Takano, Kosuke Ino, Hitoshi Shiku
Summary: In this study, we developed an electrochemical endotoxin sensor using an interdigitated array electrode (IDAE) device. The IDAE device showed high redox cycling efficiency and signal amplification rate. The sensor successfully detected p-aminophenol (pAP) released from Boc-Leu-Gly-Arg-p-aminophenol (LGR-pAP) as a product of an endotoxin-induced LAL reaction. The sensor could detect as low as 0.7 and 1.0 endotoxin unit/L after the LAL reaction for 1 h and 45 min, respectively, and these values were within the cut-off range for ultrapure dialysis fluid. Therefore, the highly sensitive endotoxin sensor is useful for ensuring medical safety.
Article
Biochemistry & Molecular Biology
Yoshinobu Utagawa, Kosuke Ino, Kaoru Hiramoto, Hitoshi Shiku
Summary: Hydrogels are widely used in cell culture applications, and specific structures are necessary for fabricating tissues and organs. Existing techniques for producing multiple-branched hydrogels are inefficient and time-consuming. To address this issue, a simple and rapid fabrication method based on viscous fingering is proposed, which only requires two plates. High-viscosity solution is introduced into the space between the plates and one plate is peeled off, resulting in the formation of multi-branched structures. This approach allows for the successful fabrication of multi-branched hydrogels within 1 minute.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Instruments & Instrumentation
Takeshi Hori, Yuya Ito, Bibek Raut, Serge Ostrovidov, Yuji Nashimoto, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji
Summary: With the increasing global aging population, the number of patients with retinal diseases requiring long-term treatment is expected to rise. Researchers have developed a 3D-printed refillable drug delivery system (DDS) that fits the curvature of the eyeball, providing a less invasive and continuous drug administration method. In laboratory tests, the DDS demonstrated sustained release of a model drug over 200 days and was able to undergo ten successive drug refills without any issues. In vivo experiments in rabbit sclera also showed promising results, indicating the potential of this DDS for long-term treatment of retinal diseases.
SENSORS AND MATERIALS
(2023)
Review
Chemistry, Physical
An Konno, Kosuke Ino, Yoshinobu Utagawa, Hitoshi Shiku
Summary: Microphysiological systems (MPSs) are cell culture systems that use mammalian cells to construct organs and tissues in vitro. Electrochemical sensors have become popular in MPSs due to their simplicity and sensitivity. This review summarizes recent advances in electrochemical imaging of MPSs and provides insightful perspectives.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Electrochemistry
Kaoru Hiramoto, Keika Komatsu, Ryota Shikuwa, An Konno, Yusuke Sato, Ayumi Hirano-Iwata, Kosuke Ino, Hitoshi Shiku
Summary: Multicellular spheroids are important models in vitro for studying biological and pathological processes. Monitoring their cellular activities without labeling is challenging, but electrochemiluminescence (ECL) has the potential to track the activities of spheroids by displaying secreted molecules adhering to an electrode.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Biomedical
Yoshinobu Utagawa, Kosuke Ino, Masahiro Takinoue, Hitoshi Shiku
Summary: This study presents a simple and rapid method for fabricating core-shell hydrogel fibers for cell culture applications. The core fibers are prepared using interfacial polyelectrolyte complexation with chitosan and DNA, and then coated with calcium alginate shell hydrogels. This method has wide applications in tissue engineering and cell analysis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Chisato Ito, Kosuke Ino, Kaoru Hiramoto, Yuji Nashimoto, Hitoshi Shiku
Summary: When a glass capillary filled with a low ion concentration solution has a nanopore at its tip, the ion concentration at the tip is higher than expected due to the formation of an electrical double layer inside the pore wall. This phenomenon, known as ion current rectification (ICR), has potential applications in bioassay methodology and biosensing procedures. However, ICR can only be induced under low ion concentrations, limiting its use under physiological conditions. This study investigates the effects of ion concentration on ICR using phosphate buffer solutions (PBS) and demonstrates successful monitoring of ICR even under physiological conditions, opening up possibilities for ICR-based biosensing applications.
Article
Chemistry, Analytical
Yoshinobu Utagawa, Kosuke Ino, Kaoru Hiramoto, Kazuyuki Iwase, Yuji Nashimoto, Itaru Honma, Hitoshi Shiku
Summary: In this study, a novel microfluidic device with a porous membrane electrode was developed for the in situ monitoring of nitric oxide (NO) released by endothelial cells in real time. This device successfully measured NO released by human umbilical vein endothelial cells and recorded the changes in NO release with culture time. This research contributes to the development of organ-on-a-chip technology for real-time in situ cell analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)