Metabolism and strategies for enhanced supply of acetyl-CoA in Saccharomyces cerevisiae

Acetyl-CoA is a kind of important cofactor that is involved in many metabolic pathways. It serves as the precursor for many interesting commercial products, such as terpenes, flavonoids and anthraquinones. However, the insufficient supply of acetyl-CoA limits biosynthesis of its derived compounds in the intracellular. In this review, we outlined metabolic pathways involved in the catabolism and anabolism of acetyl-CoA, as well as some important derived products. We examined several strategies for the enhanced supply of acetyl-CoA, and provided insight into pathways that generate acetyl-CoA to balance metabolism, which can be harnessed to improve the titer, yield and productivities of interesting products in Saccharomyces cerevisiae and other eukaryotic microorganisms. We believe that peroxisomal fatty acid beta-oxidation could be an attractive strategy for enhancing the supply of acetyl-CoA.

Automated summary

Acetyl-CoA plays a crucial role in various metabolic pathways and is a precursor for commercial products. However, its inadequate supply hinders biosynthesis of derived compounds. This review explores strategies to enhance acetyl-CoA supply and balance metabolism for improved production of interesting products in microorganisms.