A hard-sphere model of protein corona formation on spherical and cylindrical nanoparticles

A nanoparticle (NP) immersed in biological media rapidly forms a corona of adsorbed proteins, which later con-trols the eventual fate of the particle and the route through which adverse outcomes may occur. The composition and timescale for the formation of this corona are both highly dependent on both the NP and its environment. The deposition of proteins on the surface of the NP can be imitated by a process of random sequential adsorption, and, based on this model, we develop a rate-equation treatment for the formation of a corona represented by hard spheres on spherical and cylindrical NPs. We find that the geometry of the NP significantly alters the composition of the corona through a process independent of the rate constants assumed for adsorption and desorption of proteins, with the radius and shape of the NP both influencing the corona. We further investigate the roles of protein mobility on the surface of the NP and changes in the concentration of proteins.

Automated summary

Research has shown that nanoparticles rapidly form a corona of absorbed proteins in biological media, a process highly dependent on the particles themselves and their surrounding environment. The geometry of the nanoparticles significantly impacts the composition of the corona, independent of the rate constants for protein adsorption and desorption.