Article
Biochemistry & Molecular Biology
Hana Valenta, Sophie Dupre-Crochet, Mouna Abdesselem, Tania Bizouarn, Laura Baciou, Oliver Nusse, Ariane Deniset-Besseau, Marie Erard
Summary: The phagocyte NADPH oxidase is a key enzyme of the innate immune system, and the use of the chimeric protein Trimera can activate the enzyme and sustain high levels of activity, but it leads to intracellular acidification, apoptosis, and local peroxidation of lipids in the membrane.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemical Research Methods
Jack Taylor, Kevin Patio, Gabriele De Rubis, Micheal B. Morris, Christian Evenhuis, Michael Johnson, Mary Bebawy
Summary: This study examined the role of alpha II-spectrin in vesiculation of malignant and non-malignant plasma membrane, using high resolution confocal microscopy to evaluate its subcellular distribution. The results showed distinct differences in cortical spectrin localization between malignant and non-malignant cells at rest, suggesting that the redistribution of cortical alpha II-spectrin supports plasma membrane-derived EV biogenesis in malignant cells.
Article
Physics, Multidisciplinary
Usharani Nagarajan, Gregory Beaune, Andy Y. W. Lam, David Gonzalez-Rodriguez, Francoise M. Winnik, Francoise Brochard-Wyart
Summary: The study explores the interaction between cell aggregates and microparticles, revealing different spreading patterns and aggregate formations. The findings may have practical implications on cancer metastasis and treatment.
COMMUNICATIONS PHYSICS
(2021)
Article
Chemistry, Physical
Michael. J. Lain, Emma Kendrick
Summary: Commercial lithium ion cells were disassembled for electrode evaluation, showing three limiting processes during high rate pulse power tests, and specific charge and discharge parameters were identified for different power levels.
JOURNAL OF POWER SOURCES
(2021)
Article
Chemistry, Multidisciplinary
Marc Van der Hofstadt, Jean-Christophe Galas, Andre Estevez-Torres
Summary: The study demonstrates the feasibility of enzyme-DNA molecular programs in extracellular media, which can deliver DNA inside living cells and remain functional for over 48 hours. This internalization program with nonequilibrium dynamics allows for control of both the time and position of cell internalization, further achieving spatially inhomogeneous internalization.
Article
Geochemistry & Geophysics
Anna Barth, Terry Plank, Henry Towbin
Summary: Natural olivine undergoes faster water diffusion at 700-900℃ compared to 1000℃, with the presence of Fe promoting the process. The diffusion rate of water in olivine is mainly controlled by its forsterite content.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2023)
Article
Mathematics, Applied
Hardik Joshi, Brajesh Kumar Jha
Summary: In this paper, a calcium dynamics model is proposed to study cellular activities and calcium homeostasis by considering the exchange of calcium flux between intracellular and extracellular sources. A generalized two-dimensional reaction-diffusion model is formulated and analyzed for different ranges of calcium flux. The model is solved using the fractional integral transform and special functions, and the existence and uniqueness of the proposed model are discussed. The obtained results are graphically presented to illustrate the significance of calcium flux and validate the effectiveness of the method.
COMPUTERS & MATHEMATICS WITH APPLICATIONS
(2023)
Article
Chemistry, Physical
David Daniel Girardier, Hadrien Vroylandt, Sara Bonella, Fabio Pietrucci
Summary: This article investigates rare events in condensed matter and explores methods to obtain the corresponding mechanisms, free-energy landscapes, and kinetic rates by projecting high-dimensional atomic dynamics onto a collective variable. The authors propose an efficient parametrization strategy based on a limited set of molecular dynamics data, which allows accurate reconstruction of barriers and rates.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Grzegorz Bubak, Karina Kwapiszewska, Tomasz Kalwarczyk, Krzysztof Bielec, Tomasz Andryszewski, Michalina Iwan, Szymon Bubak, Robert Holyst
Summary: This study utilized single-molecule fluorescent correlation spectroscopies to show that the motion of inert probes with diameters ranging from 2.6 to 150 nm is mostly unobstructed in the nucleus, indicating the presence of interchromosomal channels filled with diluted protein solution. These channels allow various cargos to migrate freely at the nanoscale.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Manuel Rivas, Pau Turon, Carlos Aleman, Jordi Puiggali, Luis J. del Valle
Summary: The study found that internalized ACP NPs increase intracellular calcium content, leading to cytotoxic effects. Endocytosis pathways have a greater cytotoxic effect, as calcium ions can be easily released and accumulated in lysosomes and mitochondria.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Environmental Sciences
Leandro Van Langenhove, Thomas Depaepe, Lore T. Verryckt, Lucia Fuchslueger, Julian Donald, Celine Leroy, Sruthi M. Krishna Moorthy, Albert Gargallo-Garriga, M. D. Farnon Ellwood, Hans Verbeeck, Dominique Van Der Straeten, Josep Penuelas, Ivan A. Janssens
Summary: The study found that bryophytes and leaves in the canopy have high rates of free-living biological nitrogen fixation, which is crucial for nitrogen cycling in tropical forests. Nearly 2 kg of nitrogen enters the forest ecosystem through free-living BNF every year, with 40% fixed by canopy components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Zhiyang Xu, Qihao Hong, Kun Ge, Xiaoyu Shi, Xiaolei Wang, Jinxiang Deng, ZhiXiang Zhou, Tianrui Zhai
Summary: This study proposes a label-free random laser method for rapid cytometry of apoptosis in living cells. By analyzing the random lasing spectra, the percentage of apoptotic cells can be distinguished within two seconds, which is more than ten times faster than traditional flow cytometry.
Article
Biology
Valentin Dunsing, Annett Petrich, Salvatore Chiantia
Summary: This study introduces a method called scanning fluorescence spectral correlation spectroscopy (SFSCS) to investigate interactions between multiple protein species at the plasma membrane, achieving cross-talk-free cross-correlation, diffusion, and oligomerization analysis of up to four protein species.
Article
Materials Science, Multidisciplinary
Dini Kurnia Ikliptikawati, Masaharu Hazawa, Frederick T-K So, Daiki Terada, Akiko Kobayashi, Takuya F. Segawa, Masahiro Shirakawa, Richard W. Wong
Summary: In this study, optical diffraction tomography was used to quantitatively analyze the morphological and biophysical properties of living cells treated with nanodiamonds of different sizes. The technique allowed for tracking of nanodiamond aggregation and deaggregation inside cells without the need for fluorescence labeling. The findings suggest that refractive index measurements are a promising tool for real-time tracking of nanodiamonds in living cells, potentially facilitating studies on therapeutic or metabolic activities with minimal laser irradiation.
DIAMOND AND RELATED MATERIALS
(2021)
Article
Polymer Science
Niannian Lv, Xiaoyan Yin, Zhuoran Yang, Teng Ma, Huimin Qin, Bijin Xiong, Hao Jiang, Jintao Zhu
Summary: The precise control of diacetylene-containing peptide amphiphile (DPA) based supramolecular architectures is crucial for their polymerization behaviors and biomedical applications. This study explores the opposite polymerization behaviors of two DPAs with similar molecular structures and emphasizes the role of charge properties in their polymerization and cell interactions.
Article
Cell Biology
Clari Valansi, David Moi, Evgenia Leikina, Elena Matveev, Martin Grana, Leonid V. Chernomordik, Hector Romero, Pablo S. Aguilar, Benjamin Podbilewicz
JOURNAL OF CELL BIOLOGY
(2017)
Article
Cell Biology
Natalia Carbo, Nahuel Tarkowski, Emiliano Perez Ipina, Silvina Ponce Dawson, Pablo S. Aguilar
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Food Science & Technology
L. Camesasca, M. Minteguiaga, L. Farina, V Salzman, P. S. Aguilar, C. Gaggero, F. Carrau
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Facundo Giorello, Maria Jose Valera, Valentina Martin, Andres Parada, Valentina Salzman, Laura Camesasca, Laura Farina, Eduardo Boido, Karina Medina, Eduardo Dellacassa, Luisa Berna, Pablo S. Aguilar, Albert Mas, Carina Gaggero, Francisco Carrau
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Biochemical Research Methods
David Moi, Laurent Kilchoer, Pablo S. Aguilar, Christophe Dessimoz
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Silvina Ponce Dawson
Summary: The International Union of Pure and Applied Physics (IUPAP) is a scientific union representing physics communities worldwide, with a focus on increasing participation and improving conditions for women physicists. The establishment of the Working Group on Women in Physics in 1999 has significantly raised awareness of gender disparities in physics and created an active network of women physicists in many countries.
PURE AND APPLIED CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G. Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Grana, Hector Romero, Pablo S. Aguilar, Luca Jovine, Benjamin Podbilewicz
Summary: This study identifies homologs of fusogenic proteins in archaeal genomes and explores their potential roles in cell-cell fusion and gene exchange. The crystal structure of one of the proteins is solved, and ectopic expression of the protein is shown to fuse mammalian cells, suggesting its involvement in gamete fusion and somatic cell fusion.
NATURE COMMUNICATIONS
(2022)
Article
Mathematics, Interdisciplinary Applications
Estefania Piegari, Silvina Ponce Dawson
MATHEMATICAL AND COMPUTATIONAL APPLICATIONS
(2019)
Meeting Abstract
Cell Biology
C. Valansi, D. Moi, E. Leikina, E. Matveev, M. Grana, L. V. Chernomordik, H. Romero, P. S. Aguilar, B. Podbilewicz
MOLECULAR BIOLOGY OF THE CELL
(2017)
Meeting Abstract
Cell Biology
C. Valansi, D. Moi, E. Leikina, E. Matveev, M. Grana, L. V. Chernomordik, H. Romero, P. S. Aguilar, B. Podbilewicz
MOLECULAR BIOLOGY OF THE CELL
(2017)
Proceedings Paper
Computer Science, Artificial Intelligence
Daniela Megrian, Pablo S. Aguilar, Federico Lecumberry
PROGRESS IN PATTERN RECOGNITION, IMAGE ANALYSIS, COMPUTER VISION, AND APPLICATIONS, CIARP 2016
(2017)
Article
Biochemistry & Molecular Biology
E. Piegari, L. F. Lopez, S. Ponce Dawson
Article
Biochemistry & Molecular Biology
Emiliano Perez Ipina, Silvina Ponce Dawson