Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 139, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111547
Keywords
Erythropoietin; Cytoprotection; Lung injuries
Funding
- Bonus Qualite Recherche program of the University Sorbonne Paris Nord
- Institut Federatif de Recherche Biomedicale program of the University Sorbonne Paris Nord
- Legs Poix grant
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Erythropoietin (Epo) has cell-protective effects beyond its role in red blood cell synthesis, with potential applications in limiting symptoms of acute and chronic lung diseases. Research shows that Epo exhibits protective effects in multiple organs, particularly in the lung.
Erythropoietin (Epo) is a pleiotropic cytokine, essential for erythropoiesis. Epo and its receptor (Epo-R) are produced by several tissues and it is now admitted that Epo displays other physiological functions than red blood cell synthesis. Indeed, Epo provides cytoprotective effects, which consist in prevention or fight against pathological processes. This perspective article reviews the various protective effects of Epo in several organs and tries to give a proof of concept about its effects in the lung. The tissue-protective effects of Epo could be a promising approach to limit the symptoms of acute and chronic lung diseases.
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