Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 141, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111891
Keywords
Microparticle; Microvesicle; Ectosome; IgA nephropathy; Podocyte
Funding
- Kidney Research Center of Tabriz University of Medical Sciences, Tabriz, Iran [64937]
- Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Microparticles are vesicles released into the extracellular environment derived from cell plasma membranes, facilitating intercellular communication through the transfer of various lipids, cytosolic proteins, RNA, and microRNAs. The progression of diseases can affect the composition and function of these cell-derived particles, with podocyte injury playing a significant role in the pathophysiology of various glomerular diseases including IgA nephropathy.
Microparticles are a general term for different types of cell plasma membrane-originated vesicles that are released into the extracellular environment. The paracrine action of these nano-sized vesicles is crucial for intercellular communications through the transfer of diverse lipids, cytosolic proteins, RNA as well as microRNAs. The progression of different diseases influences the composition, occurrence, and functions of these cellderived particles. Podocyte injury has been shown to have an important role in the pathophysiology of many glomerular diseases including IgA nephropathy (IgAN). This review would focus on the possible potential of podocyte-derived microparticles detected in urine to be used as a diagnostic tool in IgAN.
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