Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles

(2019) Wiliam Caneschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma

(2019) T. Prashanth et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

(2019) Zhongzhong Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis

(2019) Tahia K. Mohamed et al.   BIOORGANIC CHEMISTRY

Antitumor Activity of a Novel Tyrosine Kinase Inhibitor AIU2001 Due to Abrogation of the DNA Damage Repair in Non-Small Cell Lung Cancer Cells

(2019) Hwani Ryu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model

(2019) Velma Ganga Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors

(2019) Belgin Sever et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel diosgenin derivatives containing 1,3,4-oxadiazole/thiadiazole moieties as potential antitumor agents: Design, synthesis and cytotoxic evaluation

(2019) Jinling Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New thiazole-2(3H)-thiones containing 4-(3,4,5-trimethoxyphenyl) moiety as anticancer agents

(2019) Mahsa Ansari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid

(2019) Lucie Borková et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New hydrazide-hydrazones and 1,3-thiazolidin-4-ones with 3-hydroxy-2-naphthoic moiety: Synthesis, in vitro and in vivo studies

(2018) Łukasz Popiołek et al.   BIOMEDICINE & PHARMACOTHERAPY

Discovery of ( S )-2-amino- N -(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor

(2018) Xiaofei Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors

(2018) Mehlika Dilek Altıntop et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advance in oxazole-based medicinal chemistry

(2018) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

(2018) Mehlika Altıntop et al.   MOLECULES

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues

(2017) Barbara Parrino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay

(2017) Jamerson Ferreira de Oliveira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation

(2017) Solomon Tadesse et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biakamides A–D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation

(2017) Naoyuki Kotoku et al.   JOURNAL OF ORGANIC CHEMISTRY

Anticancer potential of new steroidal thiazolidin-4-one derivatives. Mechanisms of cytotoxic action and effects on angiogenesis in vitro

(2017) Marijana B. Živković et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9

(2017) Ahmet Özdemir et al.   MOLECULES

Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazole derivatives

(2017) Thiago David dos Santos Silva et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

(2017) Takahiro Nakamura et al.   Scientific Reports

Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents

(2016) Gülhan Turan-Zitouni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

(2016) Virginia Spanò et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles

(2016) Valentina Nieddu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro antimicrobial and antitumor activity of some nitrogen heterocycles

(2016) A. I. El-Shenawy   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity

(2015) Fang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

(2015) Adile Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in Vitro Antiproliferative Evaluation of Some B-norcholesteryl Benzimidazole and Benzothiazole Derivatives

(2015) Jianguo Cui et al.   Marine Drugs

Synthesis and biological evaluation of lipid-like 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole derivatives as potential anticancer and antimicrobial agents

(2015) Alla Zablotskaya et al.   MedChemComm

Novel thiazole amine class tyrosine kinase inhibitors induce apoptosis in human mast cells expressing D816V KIT mutation

(2014) Yanli Jin et al.   CANCER LETTERS

A Novel Small-Molecule YLT205 Induces Apoptosis in Human Colorectal CellsviaMitochondrial Apoptosis PathwayIn Vitroand Inhibits Tumor GrowthIn Vivo

(2014) Yongxia Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Synthesis and evaluation of novel benzophenone-thiazole derivatives as potent VEGF-A inhibitors

(2014) T. Prashanth et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of anticancer drugs based on the hallmarks of tumor cells

(2014) Natalia Bailón-Moscoso et al.   TUMOR BIOLOGY

“ToxRTool”, a new tool to assess the reliability of toxicological data

(2009) Klaus Schneider et al.   TOXICOLOGY LETTERS