Article
Pharmacology & Pharmacy
Kimberley Elbrink, Sofie Van Hees, Rene Holm, Filip Kiekens
Summary: The study evaluated the effect of cryoprotectant type and concentration and freeze-drying process parameters on celecoxib-loaded solid lipid nanoparticles. Trehalose, maltose, and sucrose at a 1:1 weight ratio were found to be the optimal cryoprotectants for freeze-drying. Storage at 4 degrees C with trehalose as a cryoprotectant yielded the best results. The optimized freeze-drying process affected the quality and in vitro release profile of the freeze-dried cake.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Polymer Science
Alexandar M. Zhivkov, Trifon T. Popov, Svetlana H. Hristova
Summary: Hydrogels, when combined with nanoparticles, show increased drug-absorption capacity, making them suitable for use as carriers of anticancer chemotherapeutics. This review focuses on composite hydrogels with hydrophobic and hydrophilic nanoparticles, emphasizing the surface properties of the nanoparticles formed from various substances. The physicochemical properties of the nanoparticles are discussed to assist researchers in selecting the appropriate nanoparticles for drug adsorption.
Review
Chemistry, Applied
Hisashi Masui, Shinichiro Fuse
Summary: Peptides have gained increasing importance as drugs and drug candidates. Microflow synthesis, with an inner tube diameter of <=1 mm, offers advantages such as precise control of reaction time and temperature, as well as easy scale-up. The combination of microflow technology, automated synthesis, and online monitoring has improved synthetic efficiency and provided reliable data for machine learning models.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Nanoscience & Nanotechnology
Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, Maria J. Vicent, Stefaan De Koker, Bruno G. De Geest
Summary: The article discusses the development of a lipid nanoparticle (LNP) platform utilizing poly(L-glutamic acid) (PGA) as a hydrophilic backbone for conjugation of peptide antigen and an imidazoquinoline (IMDQ) TLR7/8 agonist as a molecular adjuvant. Results show that LNP encapsulation facilitates uptake by innate immune cells in lymphoid tissue and enhances the induction of antigen-specific T cell responses after subcutaneous and intravenous administration in mouse models.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Organic
Pak-Lun Lam, Yue Wu, Ka-Leung Wong
Summary: Fmoc-Dab(Mtt)-OH has poor coupling efficiency and undergoes rapid lactamization during solid-phase peptide synthesis. A multi-time and preincubation-free protocol using the coupling reagent DEPBT can achieve complete incorporation, but alternative building blocks are recommended to avoid this costly and tedious procedure.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Moataz B. Zewail, Gihan F. Asaad, Salma M. Swellam, Sama M. Abd-allah, Sahar K. Hosny, Salma K. Sallah, Jehan E. Eissa, Salma S. Mohamed, Walaa A. El-Dakroury
Summary: This study developed mucoadhesive buccal tablets containing Lornoxicam-loaded solid lipid nanoparticles to enhance solubility and bioavailability, and achieve controlled release for better anti-inflammatory effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Monica Cerqueira, Efres Belmonte-Reche, Juan Gallo, Fatima Baltazar, Manuel Banobre-Lopez
Summary: Cancer is a leading cause of death worldwide, with a projected increase in global cancer incidence in the next two decades. Nanomedicine formulations have the potential to improve the effectiveness of conventional cancer therapies. However, the targeting efficiency of advanced nanomedicines in oncology is currently one of the major limitations, highlighting the need for more efficient nanoformulation designs.
Review
Chemistry, Multidisciplinary
Palmira Alessia Cavallaro, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, Antonella Leggio
Summary: Breast cancer is a common and deadly disease, and overexpression of HER2 is a major contributing factor. This review provides an overview of the diagnosis and treatment approaches for HER2-positive breast cancer in the past decade. Antibodies and peptides are explored as targeting strategies, with nanotechnology offering potential solutions to current clinical challenges in breast cancer imaging, targeting, and therapy.
Article
Chemistry, Multidisciplinary
Haicheng Lu, Yuqian Wang, Sophie K. Hill, Hanqiu Jiang, Yubin Ke, Shaohui Huang, Dunjin Zheng, Sebastien Perrier, Qiao Song
Summary: In this study, a simple supramolecular strategy was developed to address the long-standing challenges associated with cyanine dyes, resulting in the development of ultrabright cyanine-based fluorescent materials. Through the incorporation of cyanine moieties in a cyclic peptide-based supramolecular scaffold, the resulting supra-cyanines exhibited high fluorescence quantum yields, providing a versatile approach for constructing highly emissive cyanine-based supramolecular materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Irene Marzuoli, Carlos H. B. Cruz, Christian D. Lorenz, Franca Fraternali
Summary: This study investigates the molecular mechanism, stability, and interaction of antibacterial nanocapsules with model membranes, using Molecular Dynamics and protein design strategies.
Article
Biophysics
Guliz Ak, Ayse Unal, Tugba Karakayali, Buket Ozel, Nur Selvi Gunel, Senay Hamarat Sanlier
Summary: The study demonstrates that BCNU and TMZ loaded SLNs can serve as an effective anticancer system for targeted GBM therapy, showing significant antitumor activity and inducing apoptosis on cancer cells, as well as being more readily taken up by MCT-1 expressing brain cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Barbara Vigani, Caterina Valentino, Giuseppina Sandri, Roberta Listro, Francesca Fagiani, Simona Collina, Cristina Lanni, Maria Cristina Bonferoni, Carla M. Caramella, Silvia Rossi, Franca Ferrari
Summary: A novel composite nanosystem was developed for the treatment of glioblastoma, utilizing chitosan-coated Solid Lipid Nanoparticles embedded in nanofibers for local delivery of lipophilic anti-proliferative drugs. The coated nanoparticles showed higher accumulation in human glioblastoma cells compared to uncoated ones.
Article
Pharmacology & Pharmacy
Noha S. El-Salamouni, Mennatallah A. Gowayed, Nevine L. Seiffein, Rehab A. Abdel-Moneim, Maher A. Kamel, Gihan S. Labib
Summary: The study explores the potential repurposed use of valsartan in the treatment of diabetic foot ulcers by preparing solid lipid nanoparticles. The results demonstrate that Val-SLN has a significant inhibitory effect on bacterial biofilm formation and plays a role in promoting the healing process of ulcers through multiple pathways.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Zuzana Hejdankova, Vaclav Vanek, Frantisek Sedlak, Jan Prochazka, Audrey Diederichs, Sami Kereiche, Barbora Novotna, Milos Budesinsky, Gabriel Birkus, Klara Grantz Saskova, Petr Cigler
Summary: The study introduces ionizable adamantane-based lipidoids named XMaNs, which efficiently deliver various types of nucleic acids into cells. The XMaN6 lipidoid, in particular, shows versatility in entrapment and delivery of siRNA, mRNA, plasmid DNA, and cyclic dinucleotides. This universal delivery capability could potentially accelerate the translation of lipid nanoparticles into clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Agatina Campisi, Giovanni Sposito, Rosalia Pellitteri, Debora Santonocito, Julia Bisicchia, Giuseppina Raciti, Cristina Russo, Pamela Nardiello, Rosario Pignatello, Fiorella Casamenti, Carmelo Puglia
Summary: In this study, the researchers demonstrated for the first time that the systemic administration of solid lipid nanoparticles (SLNs) to facilitate curcumin delivery can differently modulate the expression of TG2 isoforms in WT and Tg mice. It was also discovered that SLNs-CUR could be an innovative tool for the treatment of AD.
Article
Biochemistry & Molecular Biology
Shuai Yuan, Ibrahim Abdel Aziz Ibrahim, Ruimin Ren
Summary: This study aimed to investigate the ameliorative effects of daidzin against ethylene glycol-induced urolithiasis in rats. The results showed that daidzin effectively improved urinary parameters, kidney function markers, renal histopathology, and antioxidant levels.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ningning Rong, Ruyan Yang, Ibrahim Abdel Aziz Ibrahim, Wenlong Zhang
Summary: This study demonstrates the potential therapeutic effects of scopoletin in treating myocardial infarction. Scopoletin pre-treatment reduced cardiac damage, inflammation, and apoptosis markers, while increasing antioxidant enzyme levels. Scopoletin also reversed the inflammation and necrosis in the heart tissue of ISO-treated animals and increased antioxidant and anti-inflammatory properties.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Mohammad Javed Ansari, Mahfoozur Rahman, Majed Alrobaian, Waleed H. Almalki, Khalid S. Alharbi, Waleed M. Altowayan, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Tanuja Singh, Sarwar Beg
Summary: This study developed and characterized caffeine acid-loaded lipid polymer hybrid nanoparticles for treating liver cirrhosis. The nanoparticles showed suitable particle size, stability, and drug release properties, leading to improved bioavailability of caffeine acid and therapeutic effects against liver cirrhosis.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wesam F. F. Farrash, Akhmed Aslam, Riyad Almaimani, Faisal Minshawi, Hussain Almasmoum, Aiman Alsaegh, Mohammad S. S. Iqbal, Aisha Tabassum, Mohamed E. E. Elzubier, Mahmoud Z. Z. El-Readi, Amani A. A. Mahbub, Shakir Idris, Bassem Refaat
Summary: This study investigated the effects of 5-fluorouracil (5-FU), metformin (Met), and/or thymoquinone (TQ) single/dual/triple therapies on colon cancer cell lines. The triple therapy showed the highest pro-apoptotic actions and the best suppression of the PI3K/mTOR/HIF1 alpha pathway. The triple therapy also exhibited the highest increases in oxidative stress markers and the lowest antioxidant levels in all cell lines.
Article
Endocrinology & Metabolism
Bassem Refaat, Akhmed Aslam, Shakir Idris, Ahmed H. Almalki, Mofareh Y. Alkhaldi, Hassan A. Asiri, Riyad A. Almaimani, Abdulrahman Mujalli, Faisal Minshawi, Sara A. Alamri, Mona I. AlHussain, Badee A. Baltow, Mansour H. Alqasmi, Ghaiyda T. Basfar, Ohoud M. Alosaimi, Ibrahim A. Muhayya
Summary: This study reveals that the expression of estrogen and androgen receptors in colorectal cancer tissues is correlated with tumor characteristics, and hormonal therapy may serve as an alternative treatment strategy for colorectal cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rania Moataz El-Dahmy, Ibrahim Elsayed, Jihan Hussein, Mohammad Althubiti, Riyad A. Almaimani, Mahmoud Zaki El-Readi, Marawan A. Elbaset, Bassant M. M. Ibrahim
Summary: This study aimed to develop oleogel formulations to enhance the therapeutic efficacy and bioavailability of OLM. The optimized oleogel formulation showed improved release and permeation of OLM, and demonstrated better control of blood pressure and heart rate. The results confirmed the success of oleogel formulations in transdermal delivery of OLM.
Article
Endocrinology & Metabolism
Abdullatif Babakr, Mohamed Mukhtar, Mohamed Althubiti, Hiba Al-Amodi, Riyad Almaimani, Mohamed Mahmoud Nour Eldin, Mohamed Elzubeir Abdalla, Wesam Nasif
Summary: The aim of this study was to evaluate the association between lipid status and the levels of oxidized low-density lipoproteins and 8-hydroxy-2'-deoxyguanosine. The results showed a positive correlation between oxidized low-density lipoproteins and 8-hydroxy-2'-deoxyguanosine levels with hypercholesterolemia, hypertriglyceridemia, and high levels of low-density lipoproteins. This suggests that disturbance in lipid profile may result in increased levels of oxidized low-density lipoproteins and oxidative stress.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Ahmed A. J. Jabbar, Zaenah Zuhair Alamri, Mahmood Ameen Abdulla, Nur Ain Salehen, Ibrahim Abdel Aziz Ibrahim, Rawaz Rizgar Hassan, Ghassan Almaimani, Ghazi A. Bamagous, Riyad A. Almaimani, Hussain A. Almasmoum, Mazen M. Ghaith, Wesam F. Farrash, Yahya A. Almutawif
Summary: Research on the chemopreventive effects of boric acid on azoxymethane-induced colonic aberrant crypt foci in rats shows that boric acid can reduce the number of ACF and regulate the expression of apoptotic proteins, antioxidant enzymes, and inflammatory cytokines.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ahmad A. Obaid, Hussain Almasmoum, Riyad A. Almaimani, Mohamed El-Boshy, Akhmed Aslam, Shakir Idris, Mazen M. Ghaith, Mahmoud Z. El-Readi, Jawwad Ahmad, Wesam F. Farrash, Abdulrahman Mujalli, Safaa Y. Eid, Mohamed E. Elzubier, Bassem Refaat
Summary: This study showed that co-supplementing vitamin D and calcium can effectively alleviate Cd-induced nephropathy, possibly by better regulation of Ca-dependent anti-oxidative and anti-inflammatory actions.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Waleed M. Dosoky, Soha A. Farag, Hibah A. Almasmoum, Najat S. M. Khisheerah, Islam M. Youssef, Elwy A. Ashour, Laila A. Mohamed, Mahmoud Moustafa, Mohammed Al-Shehri, Mariusz Jaremko, Mohamed E. Abd El-Hack
Summary: The objective of this study was to investigate the impact of using ginger powder or frankincense oil on the production rate, blood biochemical properties, and immune response of laying Japanese quail. Results showed that ginger and frankincense oil did not affect egg production parameters, except during the period of 15-18 weeks. However, the addition of these additives improved blood serum properties and reproductive and productive performance.
Article
Chemistry, Multidisciplinary
Eman M. Radwan, Eman Abo-Elabass, Atef E. Abd El-Baky, Hussah Abdullah Alshwyeh, Riyad A. Almaimani, Ghassan Almaimani, Ibrahim Abdel Aziz Ibrahim, Abdulaziz Albogami, Mariusz Jaremko, Samar Z. Alshawwa, Essa M. Saied
Summary: This study designed, synthesized, and characterized a new class of N-(substituted phenyl)-8-methoxycoumarin-3-carboxamide analogues. The synthesized compounds showed significant cytotoxicity against Hep-G2 cells with low impact on normal cells. Compound 7 exhibited the most potent cytotoxic effect, inducing cell cycle arrest and apoptosis in Hep-G2 cells. Additionally, compound 7 displayed dual inhibitory activity against cytochrome P450 and VEGFR-2 proteins. These findings suggest that the newly synthesized compounds, particularly compound 7, hold promise as effective anticancer agents against liver cancer.
FRONTIERS IN CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
Bassam Ali Abed Wahab, Zaenah Zuhair Alamri, Ahmed A. j. Jabbar, Ibrahim Abdel Aziz Ibrahim, Riyad A. A. Almaimani, Hussain A. A. Almasmoum, Mazen M. M. Ghaith, Wesam F. F. Farrash, Yahya A. A. Almutawif, Khalid Aidarous Ageeli, Soliman Mohammed Alfaifi, Rahaf Frehan Alharthi
Summary: This study analyzed the phytochemical profile of methanol extracts of B. bovei and investigated their antioxidant, anticancer, and acute toxicity activities. The extracts were found to contain fatty acids, phytosterols, alcohols, and hydrocarbon compounds. They exhibited significant antioxidant and anticancer activities, and showed no toxicological signs in rats at high dosage.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Chemistry, Multidisciplinary
Suhayla Hamad Shareef, Ameena S. M. Juma, Derin N. F. Agha, Abdullah R. Alzahrani, Ibrahim Abdel Aziz Ibrahim, Mahmood Ameen Abdulla
Summary: The present study investigated the hepatoprotective effects of Alpinetin against TAA-induced liver cirrhosis in rats. The results showed that Alpinetin can alleviate TAA-induced liver injury, reduce liver enzyme activity, increase total protein and albumin levels, enhance SOD and CAT levels, decrease MDA levels, modulate inflammatory cytokines, inhibit cell proliferation, and exhibit a good safety profile. Therefore, Alpinetin could be a potential therapeutic agent for TAA-induced liver damage.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Manar G. Salem, Sara A. Abu El-ata, Elsherbiny H. Elsayed, Suraj N. Mali, Hussah Abdullah Alshwyeh, Ghassan Almaimani, Riyad A. Almaimani, Hussain A. Almasmoum, Najla Altwaijry, Ebtesam Al-Olayan, Essa M. Saied, Mohamed F. Youssef
Summary: Breast cancer is a global health concern with limited treatment options in underserved areas. In this study, a novel family of compounds was developed and evaluated for their inhibitory activity against breast cancer cells. Compound 3b showed significant inhibitory effect and minimal impact on normal cells. Mechanistic studies revealed the involvement of cell cycle regulation and targeting of topoisomerase II and EGFR activity by compound 3b.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)