Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy

Engineering Stimuli‐Activatable Boolean Logic Prodrug Nanoparticles for Combination Cancer Immunotherapy

(2020) Bo Hou et al.   ADVANCED MATERIALS

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

(2020) Xuexiang Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Delivery Nanomedicine for O2-Economized Photodynamic Tumor Therapy

(2020) Lin-Ping Zhao et al.   NANO LETTERS

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

(2020) Hongzhang Deng et al.   NANO LETTERS

ROS-Mediated Selective Killing Effect of Black Phosphorus: Mechanistic Understanding and Its Guidance for Safe Biomedical Applications

(2020) Na Kong et al.   NANO LETTERS

Complement Activation: A Potential Threat on the Safety of Poly(ethylene glycol)-Coated Nanomedicines

(2020) Alberto Gabizon et al.   ACS Nano

Tumor targeted self-synergistic nanoplatforms for arsenic-sensitized photodynamic therapy

(2020) Ping Yuan et al.   Acta Biomaterialia

Inducing Endoplasmic Reticulum Stress to Expose Immunogens: A DNA Tetrahedron Nanoregulator for Enhanced Immunotherapy

(2020) Yanhua Li et al.   ADVANCED FUNCTIONAL MATERIALS

Self-Delivery Photo-Immune Stimulators for Photodynamic Sensitized Tumor Immunotherapy

(2020) Lin-Ping Zhao et al.   ACS Nano

Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models

(2020) Dengshuai Wei et al.   ACS Nano

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

(2020) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes

(2019) Xiangzhao Ai et al.   Nature Communications

A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy

(2019) Hong Cheng et al.   BIOMATERIALS

Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal–Organic Framework

(2019) Yuanbo Wang et al.   ACS Nano

Nanoenabled Reversal of IDO1-Mediated Immunosuppression Synergizes with Immunogenic Chemotherapy for Improved Cancer Therapy

(2019) Hua Huang et al.   NANO LETTERS

Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H2O2 biosensor HyPer

(2019) Olga Lyublinskaya et al.   Redox Biology

Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer

(2019) Ang Gao et al.   NANO LETTERS

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

(2018) Shuangjiang Yu et al.   ADVANCED MATERIALS

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Near-infrared AIEgens as transformers to enhance tumor treatment efficacy with controllable self-assembled redox-responsive carrier-free nanodrug

(2018) Wei Zhang et al.   BIOMATERIALS

Recent advances in hepatocellular carcinoma therapy

(2017) Rinku Dutta et al.   PHARMACOLOGY & THERAPEUTICS

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

(2017) Yuying Liu et al.   Nature Communications

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo

(2015) Jinfeng Zhang et al.   ACS Nano

A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy

(2015) Samuel G. Awuah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Copper−Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

(2010) Azadeh Kheirolomoom et al.   MOLECULAR PHARMACEUTICS

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

Pharmacokinetics and pharmacogenomics in breast cancer chemotherapy

(2008) Sharon Marsh et al.   ADVANCED DRUG DELIVERY REVIEWS

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Immunogenicity of anthracyclines: moving towards more personalized medicine

(2008) Lionel Apetoh et al.   TRENDS IN MOLECULAR MEDICINE