“One-stitch” bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules

A General Strategy for Macrotheranostic Prodrug Activation: Synergy between the Acidic Tumor Microenvironment and Bioorthogonal Chemistry

(2020) Yansong Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Near-Infrared Light Dual-Promoted Heterogeneous Copper Nanocatalyst for Highly Efficient Bioorthogonal Chemistry in Vivo

(2020) Yawen You et al.   ACS Nano

Platinum-triggered Bond-cleavage of Pentynoyl amide and N-propargyl handles for Drug-Activation

(2020) Bruno L. Oliveira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using bioorthogonally catalyzed lethality strategy to generate mitochondria-targeting antitumor metallodrugs in vitro and in vivo

(2020) Xuling Xue et al.   National Science Review

Transparent, Highly Stretchable, Rehealable, Sensing, and Fully Recyclable Ionic Conductors Fabricated by One‐Step Polymerization Based on a Small Biological Molecule

(2019) Chao Dang et al.   ADVANCED FUNCTIONAL MATERIALS

Assembling a Natural Small Molecule into a Supramolecular Network with High Structural Order and Dynamic Functions

(2019) Qi Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications

(2019) Xin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy

(2018) Marcus Hoop et al.   ADVANCED FUNCTIONAL MATERIALS

Combinational strategy for high-performance cancer chemotherapy

(2018) Si-Yong Qin et al.   BIOMATERIALS

Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide

(2018) Yueqin Zheng et al.   Nature Chemistry

Bright insights into Palladium-triggered local chemotherapy

(2018) Thomas L Bray et al.   Chemical Science

Tetrazine-Mediated Bioorthogonal Prodrug-Prodrug Activation

(2018) Kevin Neumann et al.   Chemical Science

Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

(2018) Raffaella Rossin et al.   Nature Communications

Nanocopper-Doped Cross-Linked Lipoic Acid Nanoparticles for Morphology-Dependent Intracellular Catalysis

(2018) Jingsheng Huang et al.   ACS Catalysis

Exploring a naturally tailored small molecule for stretchable, self-healing, and adhesive supramolecular polymers

(2018) Qi Zhang et al.   Science Advances

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation

(2018) Miles A. Miller et al.   ACS Nano

Biogenic (R )-(+)-Lipoic Acid Only Constructed Cross-Linked Vesicles with Synergistic Anticancer Potency

(2018) Chunyan Liao et al.   ADVANCED FUNCTIONAL MATERIALS

Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

(2018) Qingxin Yao et al.   Nature Communications

Nano-palladium is a cellular catalyst for in vivo chemistry

(2017) Miles A. Miller et al.   Nature Communications

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

(2016) Ester Jiménez-Moreno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice

(2016) Raffaella Rossin et al.   BIOCONJUGATE CHEMISTRY

The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria

(2016) Bastian Dörsam et al.   CANCER LETTERS

Tetrazine-Responsive Self-immolative Linkers

(2016) Kevin Neumann et al.   CHEMBIOCHEM

Palladium-mediated in situ synthesis of an anticancer agent

(2016) Eugenio Indrigo et al.   CHEMICAL COMMUNICATIONS

In situ activation of a doxorubicin prodrug using imaging-capable nanoparticles

(2016) Irfan Khan et al.   CHEMICAL COMMUNICATIONS

Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor

(2016) Belén Rubio-Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma

(2016) Jose M. Mejia Oneto et al.   ACS Central Science

Tumour microenvironment-responsive lipoic acid nanoparticles for targeted delivery of docetaxel to lung cancer

(2016) Fenfen Gu et al.   Scientific Reports

Self-Assembling Monomeric Nucleoside Molecular Nanoparticles Loaded with 5-FU Enhancing Therapeutic Efficacy against Oral Cancer

(2015) Hang Zhao et al.   ACS Nano

Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line

(2015) Xuan Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition

(2015) Siddharth S. Matikonda et al.   Chemical Science

Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector

(2015) Mustafa M. Munye et al.   Scientific Reports

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Injectable controlled release depots for large molecules

(2014) Steven P. Schwendeman et al.   JOURNAL OF CONTROLLED RELEASE

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

(2014) Jason T. Weiss et al.   Nature Communications

Controlled Release from Cleavable Polymerized Liposomes upon Redox and pH Stimulation

(2011) Shiyong Zhang et al.   BIOCONJUGATE CHEMISTRY

Polyelectrolyte nanocages via crystallized miniemulsion droplets

(2011) Yukun Li et al.   CHEMICAL COMMUNICATIONS

1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents

(2010) Kristin Odlo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polymer-Caged Nanobins for Synergistic Cisplatin−Doxorubicin Combination Chemotherapy

(2010) Sang-Min Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Doxorubicin Prodrug Activated by the Staudinger Reaction

(2008) Remco van Brakel et al.   BIOCONJUGATE CHEMISTRY

Chitosan microspheres for encapsulation of α-lipoic acid

(2008) Rangika Weerakody et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Design and production of nanoparticles formulated from nano-emulsion templates—A review

(2008) Nicolas Anton et al.   JOURNAL OF CONTROLLED RELEASE