Article
Biochemistry & Molecular Biology
Jacqueline Georgy, Yvonne Arlt, Jens M. Moll, Meryem Ouzin, Hendrik T. Weitz, Lothar Gremer, Dieter Willbold, Joachim Groetzinger, Felix Thives-Kurenbach, Juergen Scheller, Doreen M. Floss
Summary: This study identified key amino acid residues in the p40 subunit of IL-12/IL-23 that are crucial for binding to IL-12Rβ1, providing insights into the structural basis of cytokine-cytokine receptor interactions and offering potential for the development of novel therapeutic strategies.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Josef S. Smolen, Stefan Siebert, Tatiana Korotaeva, Carlo Selmi, Paul Bergmans, Elisa Gremese, Beatriz Joven-Ibanez, Gkikas Katsifis, Wim Noel, Michael T. Nurmohamed, Pascal Richette, Petros P. Sfikakis, Kurt de Vlam, Elke Theander, Laure Gossec
Summary: The 6-month effectiveness of ustekinumab and TNFi in treating PsA patients was similar, with high baseline body mass index and cDAPSA score associated with lower chance of achieving cDAPSA LDA with TNFi. Predictive factors were consistent with previous evidence, and safety data were comparable between the two treatment groups.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Cell Biology
Alicja Mesjasz, Magdalena Trzeciak, Jolanta Glen, Marta Jaskulak
Summary: Interleukin 37 is a member of the IL-1 cytokine family with anti-inflammatory and immunosuppressive effects. It acts both extracellularly and intracellularly, and is linked to IL-18 and regulates Th2 inflammation in atopic dermatitis.
Article
Biochemistry & Molecular Biology
Chenxi Wu, Anqi Lyu, Shijun Shan
Summary: The main cause of atopic dermatitis (AD) is Th2 inflammation, and serum levels of CCL17 and CCL22 are associated with the severity of the disease. Fulvic acid (FA) is a natural substance with anti-inflammatory, antibacterial, and immunomodulatory effects. The experiments showed that FA can reduce the expression of TARC/CCL17 and MDC/CCL22 in stimulated HaCaT cells. FA inhibits the production of CCL17 and CCL22 by deactivating the p38 MAPK and JNK pathways. In mice with AD, FA effectively reduced symptoms and serum levels of CCL17 and CCL22 induced by DNCB. In conclusion, topical application of FA can alleviate AD by downregulating CCL17 and CCL22 expression via inhibition of P38 MAPK and JNK phosphorylation, making it a potential therapeutic agent for AD.
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thamires Rodrigues de Sousa, Beatriz Oliveira Fagundes, Andrezza Nascimento, Lorena Abreu Fernandes, Fabio da Ressureicao Sgnotto, Raquel Leao Orfali, Valeria Aoki, Alberto Jose da Silva Duarte, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study aimed to evaluate the effect of serum IgG from adult atopic dermatitis (AD) patients on the thymic maturation of IL-22-producing T cells and CLA+ T cells of non-atopic infants, as well as the expression of miRNAs in cultured thymocytes. The results showed that IgG from AD patients could increase the frequency of CLA+ CD4+ T cells in non-atopic infant thymocytes, and miRNA expression was altered in AD IgG-treated thymocytes compared to control conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara
Summary: IL-33 and IL-37 co-regulate the balance between inflammation and anti-inflammation, and are involved in the pathogenesis of inflammatory skin diseases such as AD and psoriasis. AHR-mediated regulation of their expression may offer new therapeutic strategies for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Berengere Villeret, Reem Ghinnagow, Saade Kheir, Maelys Born-Bony, Jay K. Kolls, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study reveals the importance of lymphocytes in fighting against Pseudomonas aeruginosa infection. The bacterium down-regulates IL-23 and IL-22 protein accumulation in the lungs, but up-regulates their RNA production. Adenovirus-mediated over-expression of IL-1, IL-23, and IL-7 can rescue mice from Pseudomonas aeruginosa-induced lethality, suggesting its potential value in locally immunosuppressed individuals like cystic fibrosis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Charlie Bridgewood, Kassem Sharif, Jane Freeston, Benazir Saleem, Tobias Russell, Abdulla Watad, Almas Khan, Peter Loughenbury, Abhay Rao, Miriam Wittmann, Dennis McGonagle
Summary: The study revealed a protective role of IL-4/IL-13 in regulating the IL-23-IL-17 axis, reducing production of IL-23 in entheses and inhibiting CCL20 secretion in entheseal fibroblasts in patients with arthritis. IL-4/IL-13 were also detected in synovial fluid of PsA patients, implying a potential link to the pathogenesis of PsA.
Review
Immunology
Charlie Bridgewood, Darren Newton, Nicola Bragazzi, Miriam Wittmann, Dennis McGonagle
Summary: The IL-23/IL-17 cytokine axis is associated with spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints, sharing some common characteristics with Th2 type or allergic diseases but also exhibiting distinct features. These findings suggest a dynamic Th2 and Th17 cytokine counter regulation in vivo in humans.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Dermatology
Astrid H. Lossius, Teresa L. Berents, Frank Saetre, Hogne R. Nilsen, Maria Bradley, Samina Asad, Guttorm Haraldsen, Olav Sundnes, Jan-oivind Holm
Summary: The early molecular responses to nb-UVB treatment in AD skin showed significant modulation of gene expression related to inflammatory response, melanin synthesis, and other functions. Interestingly, there was a noted decrease in pro-inflammatory cytokine IL-36 gamma and an increase in anti-inflammatory cytokine IL-37 after treatment with nb-UVB. This study provides important insights into the molecular mechanisms behind the treatment response and indicates potential new treatment targets.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Adrian Gomez-Nguyen, Nikhilesh Gupta, Harsha Sanaka, Dennis Gruszka, Alaina Pizarro, Luca DiMartino, Abigail Basson, Paola Menghini, Abdullah Osme, Carlo DeSalvo, Theresa Pizarro, Fabio Cominelli
Summary: The study found that psychological stress can induce the formation of colonic TLOs through intrinsic alterations in IL-23 signaling, rather than through extrinsic influence from the microbiome. Furthermore, chronic stress is protective against secondary insult from colitis, suggesting that TLOs may improve mucosal barrier function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Chul Hwan Bang, Ji Young Song, Yu Mee Song, Ji Hyun Lee, Young Min Park, Jun Young Lee
Summary: The study revealed that CD45RO(+)CLA(+)H4R(+) T cells are an important source of IL-31 in AD patients. Stimulation with 4-methylhistamine increased IL-31 production in these cells. This suggests that these cells could be a potential target for treating IL-31-induced pruritus.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
John Frew, Lauren Penzi, Mayte Suarez-Farinas, Sandra Garcet, Patrick M. Brunner, Tali Czarnowicki, Jaehwan Kim, Claire Bottomley, Robert Finney, Inna Cueto, Judilyn Fuentes-Duculan, Hanako Ohmatsu, Tim Lentini, Valerie Yanofsky, James G. Krueger, Emma Guttman-Yassky, Daniel Gareau
Summary: The study developed and validated a computer-assisted image-processing algorithm (EQscore) to reliably quantify erythema across different skin types in the dermatology clinical setting. The algorithm demonstrated high agreement with clinical scoring and superior reliability compared with clinical scoring. The EQscore is easily accessible, user-friendly, and may allow dermatologists to more readily and accurately rate the severity of dermatological conditions.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Immunology
Christine Bangert, Katharina Rindler, Thomas Krausgruber, Natalia Alkon, Felix M. Thaler, Harald Kurz, Tanya Ayub, Denis Demirtas, Nikolaus Fortelny, Vera Vorstandlechner, Wolfgang M. Bauer, Tamara Quint, Michael Mildner, Constanze Jonak, Adelheid Elbe-Buerger, Johannes Griss, Christoph Bock, Patrick M. Brunner
Summary: Therapeutic options for autoimmune diseases typically involve immunosuppressive agents, but sustained clinical benefit is rare. A study on atopic dermatitis patients treated with dupilumab found decreases in skin immune cell counts and normalization of transcriptomic dysregulation. However, specific immune cell populations persisted after clinical remission, indicating a persisting disease memory.
SCIENCE IMMUNOLOGY
(2021)
Letter
Dermatology
K. Abuabara, S. G. Nicholls, S. M. Langan, E. Guttman-Yassky, N. J. Reynolds, A. S. Paller, S. J. Brown
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Immunology
Katharina Rindler, Thomas Krausgruber, Felix M. Thaler, Natalia Alkon, Christine Bangert, Harald Kurz, Nikolaus Fortelny, Thomas B. Rojahn, Constanze Jonak, Johannes Griss, Christoph Bock, Patrick M. Brunner
Summary: The study found that the overall cell composition and proteomic profiles of spontaneously healed atopic dermatitis (AD) patients were comparable to healthy controls, without the upregulation of typical AD activity markers. Melanocytes and conventional T-cells in spontaneously healed AD skin may play a role in providing a specific regulatory environment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Kristina Navrazhina, Sandra Garcet, Juana Gonzalez, David Grand, John W. Frew, James G. Krueger
Summary: Hidradenitis suppurativa is a chronic inflammatory dermatosis characterized by high levels of neutrophil-related markers in serum and a specific molecular signature associated with the presence of dermal tunnels.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Allergy
Mika Murai-Yamamura, Sandra Garcet, Kazuhiko Yamamura, Juana Gonzalez, Shunsuke Miura, Xuan Li, Hong Hur, Emma Guttman-Yassky, James G. Krueger
Article
Allergy
Natalia Alkon, Wolfgang M. Bauer, Thomas Krausgruber, Issac Goh, Johannes Griss, Vy Nguyen, Baerbel Reininger, Christine Bangert, Clement Staud, Patrick M. Brunner, Christoph Bock, Muzlifah Haniffa, Georg Stingl
Summary: This study investigates the phenotypic and molecular features of cutaneous innate lymphoid cells (ILCs) to better understand the biological role of these cells. The findings demonstrate the flexibility of the skin immune system, with ILCs in diseased skin expressing genes characteristic of different immune types. This suggests that the skin immune system can adjust its function to adapt to the environment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Philip M. Robson, Audrey Kaufman, Alison Pruzan, Marc R. Dweck, Maria-Giovanna Trivieri, Ronan Abgral, Nicolas A. Karakatsanis, Patrick M. Brunner, Emma Guttman, Zahi A. Fayad, Venkatesh Mani
Summary: Non-invasive positron emission tomography (PET) is a powerful tool for monitoring vascular inflammation and atherosclerotic plaque, with PET/MR offering advantages in soft tissue contrast. Research shows that the scan-rescan repeatability of F-18-FDG PET/MR in the aorta and carotid arteries is less than 5%, comparable to F-18-FDG PET/CT.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Editorial Material
Hematology
Constanze Jonak, Patrick M. Brunner
Summary: The study by Najidh and colleagues provides important insights into the immunophenotypic and transcriptional profiles of circulating malignant cells in patients with Sezary syndrome.
Article
Dermatology
Kristina Navrazhina, John W. Frew, David Grand, Samuel C. Williams, Hong Hur, Juana Gonzalez, Sandra Garcet, James G. Krueger
Summary: This study reveals that brodalumab, a human anti-IL-17 receptor A monoclonal antibody, effectively reduces inflammation and improves related pathways in Hidradenitis suppurativa (HS) patients. The response to treatment is best assessed in perilesional skin, and baseline expression levels of LCN2 and IL-17A can be used as predictive biomarkers for treatment response.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katharina Rindler, Constanze Jonak, Natalia Alkon, Felix M. Thaler, Harald Kurz, Lisa E. Shaw, Georg Stingl, Wolfgang Weninger, Florian Halbritter, Wolfgang M. Bauer, Matthias Farlik, Patrick M. Brunner
Summary: The study identified a specific panel of biomarkers associated with disease progression in mycosis fungoides (MF) patients, which may be used for monitoring MF disease progression. Altered expression of these genes may underlie the switch in clinical phenotype observed in advanced-stage MF.
Article
Allergy
Tamara Quint, Valerie Dahm, Dariga Ramazanova, Michael A. Arnoldner, Harald Kurz, Stefan Janik, Patrick M. Brunner, Birgit Knerer-Schally, Wolfgang Weninger, Johannes Griss, Robin Ristl, Sven Schneider, Christine Bangert
Summary: This study investigated the effect of omalizumab treatment on aspirin tolerance in atopic and nonatopic N-ERD patients. The results showed that omalizumab can improve aspirin tolerance in the majority of patients, regardless of atopic sensitization, and has a positive impact on chronic rhinosinusitis with nasal polyps, asthma, and biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Dermatology
Merav Koschitzky, Kristina Navrazhina, Michael S. Garshick, Juana Gonzalez, Joseph Han, Sandra Garcet, James G. Krueger
Summary: This study aimed to identify biomarkers of cardiovascular (CV) risk in psoriasis blood that are reduced by ustekinumab. The results showed that 43 out of 276 proteins were down-regulated after treatment, and 8 of them were initially elevated above thresholds associated with enhanced CV risk.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Andrew Blauvelt, Mark Boguniewicz, Patrick M. Brunner, Paula C. Luna, Pinaki Biswas, Marco DiBonaventura, Saleem A. Farooqui, Ricardo Rojo, Michael C. Cameron
Summary: In these trials, patients with moderate-to-severe atopic dermatitis treated with abrocitinib showed rapid and clinically meaningful improvements in skin clearance, itch, and quality of life, regardless of their response status.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Claire Q. Wang, Sokol Haxhinasto, Sandra Garcet, Norma Kunjravia, Inna Cueto, Juana Gonzalez, Darshna Rambhia, Olivier Harari, Matthew A. Sleeman, Jennifer D. Hamilton, Wei Keat Lim, Jan Freudenberg, George D. Kalliolias, Paresh Thakker, Robert Bissonnette, James G. Krueger
Summary: Palmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar psoriasis (NPPP) are localized, debilitating forms of psoriasis. This study found that NPPP shows more pronounced T helper 1-mediated inflammation, while PPPP exhibits stronger neutrophil-associated activity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)