Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice

Ins1-Cre and Ins1-CreER gene replacement alleles are susceptible to silencing by DNA hypermethylation

(2020) Elham Mosleh et al.   ENDOCRINOLOGY

Of mice and men, redux: modern challenges in beta cell gene targeting

(2020) Jennifer L Estall et al.   ENDOCRINOLOGY

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

(2020) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel strategies to target PCSK9: beyond monoclonal antibodies

(2019) Nabil G Seidah et al.   CARDIOVASCULAR RESEARCH

Efficacy and safety of proprotein convertase subtilisin/kexin 9 inhibitors in people with diabetes and dyslipidaemia

(2019) Wieneke Dijk et al.   DIABETES OBESITY & METABOLISM

PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor

(2018) Lorenzo Da Dalt et al.   EUROPEAN HEART JOURNAL

Key aspects of PCSK9 inhibition beyond LDL lowering

(2018) Stéphane Ramin-Mangata et al.   CURRENT OPINION IN LIPIDOLOGY

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

(2017) Amand F Schmidt et al.   Lancet Diabetes & Endocrinology

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

(2016) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Phenotypic Characterization of MIP-CreERT1LphiMice With Transgene-Driven Islet Expression of Human Growth Hormone

(2015) Daniel Oropeza et al.   DIABETES

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

(2015) Anna Roubtsova et al.   JOURNAL OF LIPID RESEARCH

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

(2015) Daniel I Swerdlow et al.   LANCET

Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

(2014) Bas Brouwers et al.   Cell Metabolism

Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic β-cells

(2014) Natalia A Tamarina et al.   Islets

Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice 性别与西方饮食对CSK9基因缺陷的PC57BL/6老龄小鼠的脂质以及葡萄糖内稳态的不同影响

(2014) Majambu Mbikay et al.   Journal of Diabetes

Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue

(2011) Anna Roubtsova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

(2010) J. K. Kruit et al.   DIABETOLOGIA

In VivoEvidence That Furin from Hepatocytes Inactivates PCSK9

(2010) Rachid Essalmani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

PCSK9 Dominant Negative Mutant Results in Increased LDL Catabolic Rate and Familial Hypobetalipoproteinemia

(2009) Bertrand Cariou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PCSK9 is expressed in pancreatic δ-cells and does not alter insulin secretion

(2009) Cédric Langhi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low- and High-Density Lipoproteins Modulate Function, Apoptosis, and Proliferation of Primary Human and Murine Pancreatic β-Cells

(2009) Sabine Rütti et al.   ENDOCRINOLOGY

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities

(2009) Majambu Mbikay et al.   FEBS LETTERS

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

(2008) Ahmed Zaid et al.   HEPATOLOGY

Cholesterol in islet dysfunction and type 2 diabetes

(2008) Liam R. Brunham et al.   JOURNAL OF CLINICAL INVESTIGATION