Hunting the genes in male-pattern alopecia: how important are they, how close are we and what will they tell us?

A Guide to Studying Human Hair Follicle Cycling In Vivo

(2016) Ji Won Oh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prediction of male-pattern baldness from genotypes

(2015) Fan Liu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research

(2015) Thomas Andl et al.   EXPERIMENTAL DERMATOLOGY

Human hair follicle organ culture: theory, application and perspectives

(2015) Ewan A. Langan et al.   EXPERIMENTAL DERMATOLOGY

The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

(2015) Kai Kretzschmar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Towards a consensus on how to diagnose and quantify female pattern hair loss - The ‘Female Pattern Hair Loss Severity Index (FPHL-SI)’

(2015) M. Harries et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

(2015) Magdalena Marcińska et al.   PLoS One

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

(2015) Jialiang Yang et al.   Scientific Reports

Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicle

(2014) T.W. Fischer et al.   BRITISH JOURNAL OF DERMATOLOGY

From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis

(2014) Y. Okada   CLINICAL GENETICS

Potential targets in the discovery of new hair growth promoters for androgenic alopecia

(2014) Ruchy Jain et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Alopecia and its association with coronary heart disease and cardiovascular risk factors: A meta-analysis

(2014) Nelson Trieu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

NF-κB Activity Is Required for Anagen Maintenance in Human Hair Follicles In Vitro

(2014) Jennifer E. Kloepper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

A guide to genome engineering with programmable nucleases

(2014) Hyongbum Kim et al.   NATURE REVIEWS GENETICS

An Overview of Alopecias

(2014) J. Qi et al.   Cold Spring Harbor Perspectives in Medicine

Early-Onset Alopecia and Amyotrophic Lateral Sclerosis: A Cohort Study

(2013) E. Fondell et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors

(2013) Ole A. Andreassen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inducible Knockout of Twist1 in Young and Adult Mice Prolongs Hair Growth Cycle and Has Mild Effects on General Health, Supporting Twist1 as a Preferential Cancer Target

(2013) Yan Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss

(2013) Rima Nuwaihyd et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Evidence for a polygenic contribution to androgenetic alopecia

(2013) S. Heilmann et al.   BRITISH JOURNAL OF DERMATOLOGY

New investigational drugs for androgenetic alopecia

(2013) Isabel Cristina Valente Duarte de Sousa et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

(2013) Stefanie Heilmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Identification of Shared Genes and Pathways: A Comparative Study of Multiple Sclerosis Susceptibility, Severity and Response to Interferon Beta Treatment

(2013) Sunil Mahurkar et al.   PLoS One

Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth

(2013) C. A. Higgins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Androgen actions on the human hair follicle: perspectives

(2012) Shigeki Inui et al.   EXPERIMENTAL DERMATOLOGY

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

Genetic and epigenetic contribution to complex traits

(2012) H. Kilpinen et al.   HUMAN MOLECULAR GENETICS

Regulation of Hair Shedding by the Type 3 IP3 Receptor

(2012) Mai Sato-Miyaoka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

(2012) Amos Gilhar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Wnt Signaling in Skin Development, Homeostasis, and Disease

(2012) X. Lim et al.   Cold Spring Harbor Perspectives in Biology

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

(2012) Christina M. Lill et al.   PLoS Genetics

Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

(2012) Rui Li et al.   PLoS Genetics

What is complex about complex disorders?

(2012) Kevin J Mitchell   GENOME BIOLOGY

Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

(2011) J.E. Cobb et al.   BRITISH JOURNAL OF DERMATOLOGY

Hair through the female life cycle

(2011) A.G. Messenger   BRITISH JOURNAL OF DERMATOLOGY

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness

(2011) F.F. Brockschmidt et al.   BRITISH JOURNAL OF DERMATOLOGY

Androgenetic alopecia as an early marker of benign prostatic hyperplasia

(2011) Salvador Arias-Santiago et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Shared Molecular and Functional Frameworks among Five Complex Human Disorders: A Comparative Study on Interactomes Linked to Susceptibility Genes

(2011) Ramesh Menon et al.   PLoS One

Deflating the Genomic Bubble

(2011) J. P. Evans et al.   SCIENCE

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

(2011) Alexandra Zhernakova et al.   PLoS Genetics

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Fine mapping of the human AR/EDA2R locus in androgenetic alopecia

(2010) F.F. Brockschmidt et al.   BRITISH JOURNAL OF DERMATOLOGY

Female pattern hair loss: beyond an androgenic aetiology?

(2010) E.A. Langan et al.   BRITISH JOURNAL OF DERMATOLOGY

Modelling the hair follicle dermal papilla using spheroid cell cultures

(2010) Claire A. Higgins et al.   EXPERIMENTAL DERMATOLOGY

Has the revolution arrived?

(2010) Francis Collins   NATURE

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

(2010) Nicholas Eriksson et al.   PLoS Genetics

Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans

(2009) Sarah E. Medland et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common vs. rare allele hypotheses for complex diseases

(2009) Nicholas J Schork et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture

(2009) Jennifer Elisabeth Kloepper et al.   EXPERIMENTAL DERMATOLOGY

Androgen Receptor Copy Number Variation and Androgenetic Alopecia: A Case-Control Study

(2009) Joanna E. Cobb et al.   PLoS One

Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State

(2009) Alice Gerrits et al.   PLoS Genetics

Androgenetic alopecia and insulin resistance in young men

(2008) José Gerardo González-González et al.   CLINICAL ENDOCRINOLOGY

EDA2R Is Associated with Androgenetic Alopecia

(2008) Dionigio Antonio Prodi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Human Folliculoid Microsphere Assay for Exploring Epithelial– Mesenchymal Interactions in the Human Hair Follicle

(2008) Blanka Havlickova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Erratum: Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Susceptibility variants for male-pattern baldness on chromosome 20p11

(2008) Axel M Hillmer et al.   NATURE GENETICS

Male-pattern baldness susceptibility locus at 20p11

(2008) J Brent Richards et al.   NATURE GENETICS

CR6-Interacting Factor 1 Represses the Transactivation of Androgen Receptor by Direct Interaction

(2007) Ji Ho Suh et al.   MOLECULAR ENDOCRINOLOGY