Article
Immunology
Juan Li, Shirong Ruan, Jinhui Jia, Qian Li, Rumeng Jia, Li Wan, Xing Yang, Peng Teng, Qilin Peng, Ya-dan Shi, Pan Yu, Yinbing Pan, Man-lin Duan, Wen-Tao Liu, Li Zhang, Liang Hu
Summary: This study confirms for the first time that hydrogen can be used as a therapeutic agent to alleviate postoperative pain through the Trx1/ASK1/MMP9 signaling pathway. MMP-9 and ASK1 may be the target molecules for relieving postoperative pain.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Wen Ding, Hong Feng, Wen-Jing Li, Hai-Han Liao, Nan Zhang, Zi-Ying Zhou, Shan-Qi Mou, Zheng Lin, Na-Zi Xia-He, Hao Xia, Qi-Zhu Tang
Summary: The study found that APO treatment effectively improved cardiac function, reduced cardiac hypertrophy and fibrosis, and decreased oxidative stress in DCM. Mechanistically, APO suppressed apoptosis through inhibiting the ASK1-p38/JNK signaling pathway. In vitro experiments also showed that APO could inhibit NRCM apoptosis and CF activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Junlin Ge, Rili Hao, Xue Rong, Q. Ping Dou, Xintong Tan, Guannan Li, Feng Li, Dapeng Li
Summary: The polyphenolic compound SDG found in flaxseed has been shown to protect mice from BaP-induced liver and kidney toxicity by regulating oxidative stress, inflammation, and apoptosis. SDG administration resulted in lower levels of liver and kidney damage markers and modulation of specific signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Takashi Toyama, Takayuki Hoshi, Takuya Noguchi, Yoshiro Saito, Atsushi Matsuzawa, Akira Naganuma, Gi-Wook Hwang
Summary: Methylmercury-induced neuronal cell death in the mouse brain may be associated with activation of the ASK1/p38 pathway by mitochondrial ROS, leading to TNF-alpha expression and microglia involvement.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Yanwen Luo, Jiefu Zhu, Fan Zhao, Lang Shi, Yuzhen Li, Xiongfei Wu
Summary: This study investigated the role of PIM1 in renal ischemia-reperfusion injury (IRI) and its downstream regulatory mechanism. The study found that PIM1 expression was significantly upregulated in renal IRI mouse model and in renal tubular cell HR model. Overexpression of PIM1 ameliorated renal IRI, possibly through the ASK1-MAPK pathway. Therefore, PIM1 may be a potential therapeutic target for renal IRI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiaming Yuan, Chenjuan Yao, Jing Tang, Yingqi Liu, Chunyan Huang, Shali Yu, Haiyan Wei, Yu Han, Gang Chen
Summary: The study revealed that under As2O3-induced ER stress conditions, GRP78 protein expression was enhanced, possibly due to increased biosynthesis of GRP78 protein. Additionally, the IRE1 alpha kinase/ASK1/p38 MAPK signaling pathway was found to play a key role in the upregulation of GRP78 protein in BEAS-2B cells.
Article
Biology
Alejandra Escos, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego Gonzalez-Romero, Ana Risco, Jose Martin-Gomez, Eric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan Jose Sanz-Ezquerro, Steven C. Ley, Ana Cuenda
Summary: Evidence implicating p38? and p38d in inflammation is mainly based on experiments using Mapk12/Mapk13-deficient mice. A new mouse model, p38?/dKIKO, with specific depletion of p38? and p38d was generated to study their functions. The results showed reduced inflammation, susceptibility to septic shock, and Candida albicans infection in p38?/dKIKO mice compared to wild-type mice. Gene expression and phosphorylation analyses revealed the involvement of p38?/p38d in regulating innate immune responses through MEF2D phosphorylation and transcriptional activity.
Article
Biochemistry & Molecular Biology
Huan Li, Qin Yang, Zhen Huang, Cui Liang, Dian-Hong Zhang, Hui-Ting Shi, Jia-Qi Du, Bin-Bin Du, Yan-Zhou Zhang
Summary: Diabetic cardiomyopathy (DCM) is a heart dysfunction that occurs in patients with diabetes mellitus (DM). This study found that dual-specificity phosphatase 12 (DUSP12) plays an important role in DCM. Overexpression of DUSP12 worsens cardiac dysfunction and increases oxidative stress and apoptosis, while DUSP12 deficiency exacerbates these effects. The study also found that DUSP12 interacts with a specific signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Immunology
Hedieh Sadat Shamsnia, Mahtab Roustaei, Danial Ahmadvand, Alexandra E. Butler, Dorsa Amirlou, Sanam Soltani, Saeideh Momtaz, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
Summary: Curcumin, a herbal remedy, possesses anti-inflammatory, antioxidant, and anticancer properties and impacts various signaling pathways including NF-KB, ROS, Wnt, JAK/STAT. P38, a part of the MAPK signaling pathway, plays a crucial role in inflammation, cell differentiation, proliferation, motility, and survival. Extensive evidence confirms that curcumin exerts anti-inflammatory, neuroprotective, and apoptotic effects by modulating the P38 MAPK signaling pathway.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose A. Martina, Eutteum Jeong, Rosa Puertollano
Summary: TFEB-S401 phosphorylation is linked to the transcriptional control of monocyte differentiation.
Article
Medicine, Research & Experimental
Qijing Wu, Juan Chen, Xiyin Zheng, Jing Song, Lulu Yin, Hai Guo, Qian Chen, Yi Liu, Qianli Ma, Hong Zhang, Qianqian Yang
Summary: The study aimed to evaluate the protective effect of kaempferol (KPF) in doxorubicin (DOX)-induced nephrotoxicity. The results showed that KPF could alleviate DOX-induced renal injury, improve proteinuria and renal function, restore antioxidant activity in kidneys, suppress oxidative stress, and inhibit the activation of the MAPK signaling pathway. In cell experiments, KPF also inhibited DOX-induced ROS overproduction, reduced cell damage and loss of viability. Therefore, KPF may provide a viable solution to lessen renal toxicity in cancer patients receiving DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Natalia Garcia-Flores, Jaime Jimenez-Suarez, Cristina Garnes-Garcia, Diego M. Fernandez-Aroca, Sebastia Sabater, Ignacio Andres, Antonio Fernandez-Aramburo, Maria Jose Ruiz-Hidalgo, Borja Belandia, Ricardo Sanchez-Prieto, Francisco J. Cimas
Summary: p38 MAPKs are a family of key proteins that regulate the stress response of human cells, controlling relevant biological phenomena such as the cell cycle. Their role in the cellular response to ionizing radiation and radiotherapy is crucial. This review provides insights into their role in response to radiation and the implications for radiotherapy.
Review
Chemistry, Medicinal
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Nicola Lombardo, Angela Sciacqua, Rocco Savino, Girolamo Pelaia
Summary: The p38 MAPK subgroup plays a crucial role in the pathogenesis of asthma and COPD by regulating the expression of various inflammatory mediators and fibrogenic factors. Studies suggest that p38 MAPK may be a potential therapeutic target, with research evaluating its effects in both asthma and COPD treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jeremy C. Burton, William Antoniades, Jennifer Okalova, Morgan M. Roos, Neil J. Grimsey
Summary: The MAPK p38 plays a crucial role in regulating responses to environmental stress and inflammation. A newly identified atypical p38 signaling pathway driven by direct interaction between TAB1 and p38α has been linked to various diseases including dermal and vascular inflammation, myocardial ischemia, and cancer metastasis. Further studies are needed to fully understand the implications and mechanisms of atypical p38 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Reem M. Hashem, Laila A. Rashd, Khalid S. Hashem, Hatem M. Soliman
BIOMEDICINE & PHARMACOTHERAPY
(2015)
Article
Neurosciences
Rasha M. Hussein, Reem M. Hashem, Leila A. Rashed
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2015)
Article
Nutrition & Dietetics
Reem M. Hashem, Rasha H. Mohamed, Dina M. Abo-El-Matty
Article
Chemistry, Multidisciplinary
Mohamed O. Mahmoud, Heba M. Aboud, Amira H. Hassan, Adel A. Ali, Thomas P. Johnston
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Medicine, Research & Experimental
Kamel M. A. Hassanin, Mohamed O. Mahmoud, Hossam M. Hassan, Abdel-Razik H. Abdel-Razik, Lourin N. Aziz, Mostafa E. Rateb
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Marwa Abdeltawab Mohammed, Mohamed O. Mahmoud, Ashraf Sayed Awaad, Gehad Mohamed Gamal, Dina Abdelfatah
Article
Pharmacology & Pharmacy
Heba M. Aboud, Mohamed O. Mahmoud, Marwa Abdeltawab Mohammed, Mohammad Shafiq Awad, Dina Sabry
JOURNAL OF DRUG TARGETING
(2020)
Article
Medicine, Research & Experimental
Mohamed A. Kandeil, Mohamed O. Mahmoud, Abdel-Razik H. Abdel-Razik, Safaa B. Gomaa
Article
Biochemistry & Molecular Biology
Mohamed A. Kandeil, Reem M. Hashem, Mohamed O. Mahmoud, Mona H. Hetta, Mohamed A. Tohamy
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Biology
R. M. Hashem, L. A. Rashed, R. M. Abdelkader, K. S. Hashem
Summary: The study demonstrated that MSCs therapy effectively replaced neointimal SMCs and reduced adhesion molecules, oxidative stress, and inflammatory markers in atherosclerosis, as evidenced by histopathological and biochemical analyses. Resveratrol was used as a benchmark to evaluate the efficacy of stem cell therapy, showing significant improvements in the experimental model of atherosclerosis.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mohamed A. Kandeil, Safaa B. Gomaa, Mohamed O. Mahmoud
Review
Oncology
Wafaa M. Rashed, Mohamed Ahmed Mohamed Kandeil, Mohamed O. Mahmoud, Sameera Ezzat
JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE
(2020)
Article
Medicine, Research & Experimental
Reem M. Hashem, Laila A. Rashed, Kamel M. A. Hassanin, Mona H. Hetta, Asmaa O. Ahmed
BIOMEDICINE & PHARMACOTHERAPY
(2017)