Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 44, Issue 4, Pages 144-149Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000089
Keywords
fatigue; calcium-sensitivity; muscle; phosphate; acidosis; regulation
Categories
Funding
- American Heart Association [14GRNT20450002]
Ask authors/readers for more resources
Muscle fatigue can result from either the accumulation of metabolic by-products (e.g., P-i and H+) or a decrease in myoplasmic Ca++; however, individually, neither change can explain quantitatively the decrease in force capacity. Therefore, the emerging view is that, by decreasing the sensitivity of myofilaments to calcium, P-i and H+ act synergistically with decreased Ca++ levels to contribute to fatigue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available