Editorial Material
Oncology
Elizabeth J. Cathcart-Rake, Tara Sanft, Amye J. Tevaarwerk
Summary: Sella and colleagues shed light on the potential mechanisms underlying weight changes for young survivors after breast cancer diagnosis. However, policy and regulatory changes are necessary to target modifiable determinants of health and implement practical, sustainable interventions based on this information.
Article
Oncology
Julia Foldi, Anastasia Tsagianni, Max Salganik, Catherine A. Schnabel, Adam Brufsky, G. J. van Londen, Lajos Pusztai, Tara Sanft
Summary: Extending adjuvant endocrine therapy beyond the standard 5 years can protect against late breast cancer recurrences. This study evaluated persistence to extended therapy in women who had Breast Cancer Index testing, and found high rates of persistence in patients with predicted high likelihood of benefit.
Article
Oncology
Tal Sella, Philip D. Poorvu, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ann H. Partridge, Shoshana M. Rosenberg
Summary: The study found that one-third of young women with breast cancer were affected by fertility concerns when making decisions about endocrine therapy, with parity at diagnosis being the main factor associated with these concerns. Women with fertility-related concerns were more likely to be nonpersistent in their endocrine therapy use compared to those without fertility concerns.
Article
Oncology
Katherine E. Reeder-Hayes, Melissa A. Troester, Stephanie B. Wheeler
Summary: There is a well-known and persistent racial disparity in breast cancer outcomes between Black and White women in the U.S., especially among those with hormone receptor-positive cancers. This gap has widened over time despite advancements in treatment, and lower adherence to endocrine therapy for Black women may be a key factor. Interventions focusing on improving communication and support for endocrine therapy use could help reduce this racial gap in breast cancer mortality.
Review
Oncology
Finn Magnus Eliassen, Vibeke Blafjelldal, Thomas Helland, Cathrine Fonnesbech Hjorth, Kari Holland, Lise Lode, Bjorn-Erik Bertelsen, Emiel A. M. Janssen, Gunnar Mellgren, Jan Terje Kvaloy, Havard Soiland, Tone Hoel Lende
Summary: This systematic review examines the importance of adjuvant endocrine treatment and the impact of non-adherence and non-persistence on the survival outcomes of breast cancer patients. The findings suggest that non-adherence and non-persistence can lead to reduced event-free survival and overall survival rates, highlighting the need for improved adherence and persistence to optimize health outcomes in non-metastatic breast cancer patients.
Review
Oncology
Kirsti I. Toivonen, Tamara M. Williamson, Linda E. Carlson, Lauren M. Walker, Tavis S. Campbell
Summary: The study found that self-efficacy and positive decisional balance were the most consistently associated modifiable factors with AET adherence or persistence. Side effects were less likely to be associated with adherence compared to other factors. Therefore, focusing on self-efficacy and decisional balance may be relevant for interventions to improve AET adherence among breast cancer survivors.
Article
Oncology
Marc A. Emerson, Ninah S. Achacoso, Halei C. Benefield, Melissa A. Troester, Laurel A. Habel
Summary: The study found that American Indian/Alaska Native (AIAN) women enrolled in the KPNC health system have lower rates of initiation and adherence to adjuvant endocrine therapy (AET) compared to other races/ethnicities.
Editorial Material
Oncology
Niamh C. Cunningham, Nicholas C. Turner
Summary: CDK4/6 inhibitors have shown consistent efficacy in the treatment of metastatic breast cancer, but recent adjuvant trials for early stage breast cancer have produced conflicting results, highlighting the need for further research on their clinical utility and future trial design.
Article
Oncology
Yasemin Uslu, Vildan Kocatepe, Derya Subasi Sezgin, Cihan Uras
Summary: The purpose of this study was to investigate adjuvant tamoxifen adherence and associated factors in breast cancer survivors. The results showed that overall, breast cancer survivors in the study had moderate adherence to tamoxifen. Individual characteristics and treatment-related adverse effects influenced medication adherence. Healthcare professionals can increase adherence to this treatment by explaining its importance, addressing barriers to adherence, and providing evidence-based interventions.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Alexandra Thomas, Heather A. Parsons, Karen Lisa Smith
Summary: The Oncology Grand Rounds series aims to integrate research reports with clinical practice, helping readers better understand how to apply research findings to patient treatments.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Caitriona Cahir, Kathleen Bennett, Stephan U. Dombrowski, Catherine M. Kelly, Mary Wells, Eila Watson, Linda Sharp
Summary: To develop intervention for endocrine therapy (ET) non-adherence in women with breast cancer, this study measured modifiable determinants using Theoretical Domains Framework (TDF) and examined their relationships using Perceptions and Practicalities Approach (PAPA). The final model explained 59% of non-adherence variance and had an acceptable fit. Knowledge mediated non-adherence through beliefs about consequences and capabilities. Illness intrusiveness mediated non-adherence through beliefs about consequences. Beliefs about consequences mediated non-adherence through memory, attention, decision processes, and environment.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
David Hicks, Ruth M. O'Regan
Summary: The Oncology Grand Rounds series aims to contextualize original reports published in the Journal into clinical practice. By presenting case studies, discussing diagnostic and management challenges, reviewing relevant literature, and providing suggested management approaches, the series helps readers better understand how to apply key research findings.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Caiwei Zheng, Anees B. Chagpar
Summary: Approximately 12% of breast cancer survivors prescribed medications within the first 5 years of diagnosis forego treatment due to cost, with family income and insurance status being key drivers.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Nicole Mavingire, Petreena Campbell, Jonathan Wooten, Joyce Aja, Melissa B. Davis, Andrea Loaiza-Perez, Eileen Brantley
Summary: Breast cancer stem cells (BCSCs) play a role in promoting endocrine therapy resistance through signaling cascades such as Notch, HIF, and integrin/Akt. Understanding these mechanisms can potentially lead to targeted therapy strategies to counteract endocrine resistance in HR positive breast cancer patients. Additionally, exploring the link between BCSC-regulatory gene levels and reduced survival in African American women with basal-like breast cancer may provide insights for improving clinical outcomes in this population.
Article
Oncology
Olivia Pagani, Barbara A. Walley, Gini F. Fleming, Marco Colleoni, Istvan Lang, Henry L. Gomez, Carlo Tondini, Harold J. Burstein, Matthew P. Goetz, Eva M. Ciruelos, Vered Stearns, Herve R. Bonnefoi, Silvana Martino, Charles E. Geyer, Claudio Chini, Fabio Puglisi, Simon Spazzapan, Thomas Ruhstaller, Eric P. Winer, Barbara Ruepp, Sherene Loi, Alan S. Coates, Richard D. Gelber, Aron Goldhirsch, Meredith M. Regan, Prudence A. Francis
Summary: The combined analysis of SOFT-TEXT compared the outcomes of 4,690 premenopausal women with ER/PgR+ early breast cancer randomly assigned to exemestane + OFS or tamoxifen + OFS. Exemestane + OFS showed significant improvement in DFS and DRFI, but not overall survival, compared to tamoxifen + OFS. This study provides guidance for selecting patients who may benefit from exemestane over tamoxifen in the setting of OFS.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maciej A. Mazurowski, Ashirbani Saha, Michael R. Harowicz, Elizabeth Hope Cain, Jeffrey R. Marks, P. Kelly Marcom
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Review
Clinical Neurology
Brett Ankawi, Robert D. Kerns, Sara N. Edmond
CURRENT PAIN AND HEADACHE REPORTS
(2019)
Review
Geriatrics & Gerontology
Sarah Sammons, Mina S. Sedrak, Gretchen G. Kimmick
Review
Geriatrics & Gerontology
Addie Hill, Eutiquio Gutierrez, Jennifer Liu, Sarah Sammons, Gretchen Kimmick, Mina S. Sedrak
Article
Oncology
Nadine M. Tung, Mark E. Robson, Steffen Ventz, Cesar A. Santa-Maria, Rita Nanda, Paul K. Marcom, Payal D. Shah, Tarah J. Ballinger, Eddy S. Yang, Shaveta Vinayak, Michelle Melisko, Adam Brufsky, Michelle DeMeo, Colby Jenkins, Susan Domchek, Alan D'Andrea, Nancy U. Lin, Melissa E. Hughes, Lisa A. Carey, Nick Wagle, Gerburg M. Wulf, Ian E. Krop, Antonio C. Wolff, Eric P. Winer, Judy E. Garber
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Anesthesiology
Brian C. Coleman, Joseph L. Goulet, Diana M. Higgins, Harini Bathulapalli, Todd Kawecki, Christopher B. Ruser, Lori A. Bastian, Steve Martino, John D. Piette, Sara N. Edmond, Alicia A. Heapy
Summary: The study explores the most frequently used musculoskeletal diagnoses in Veterans Health Administration care, with the top ones being low back pain and cervicalgia. Most patients have at least one of these common diagnoses.
Editorial Material
Health Care Sciences & Services
Sara N. Edmond
Summary: A positive COVID-19 test before birth not only alters a mother's birthing experience, but also raises suspicion from her healthcare providers.
Article
Rheumatology
Tamara J. Somers, James A. Blumenthal, Caroline S. Dorfman, Kim M. Huffman, Sara N. Edmond, Shannon N. Miller, Anava A. Wren, David Caldwell, Francis J. Keefe
Summary: Incorporating pain coping skills training into a behavioral weight loss intervention may improve outcomes for patients with rheumatoid arthritis (RA). This pilot study found that participants in the intervention group showed reductions in weight and waist circumference, as well as improvements in physical functioning, eating behaviors, pain, and self-efficacy for weight control. The feasibility data collected will inform future larger randomized trials of this intervention.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Sara N. Edmond, Jennifer L. Snow, Jamie Pomeranz, Raymond Van Cleve, William C. Becker
Summary: The goal of this study was to understand perspectives on whether a new diagnostic entity is needed for patients with chronic pain on long-term opioid therapy. While experts disagree on this issue, there is an overall acknowledgement that the current diagnosis of opioid use disorder does not meet the needs of providers and patients.
Editorial Material
Anesthesiology
Sara N. Edmond, Sophia Currie, Amanda Gehrke, Caroline G. Falker, Minhee Sung, Audrey Abelleira, Ellen L. Edens, William C. Becker
Article
Health Care Sciences & Services
Raymond Van Cleve, Sara Edmond, Jennifer Snow, Anne C. Black, Jamie L. Pomeranz, William Becker
Summary: This study aims to determine the need for a new diagnostic entity and its criteria through a modified Delphi technique. The researchers are currently gathering and analyzing responses from experts in order to generate a preliminary definition for this clinical phenomena. The study is in progress and analysis is underway.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Medicine, Research & Experimental
Lori A. Bastian, Mary Driscoll, Eric DeRycke, Sara Edmond, Kristin Mattocks, Joe Goulet, Robert D. Kerns, Mark Lawless, Caroline Quon, Kim Selander, Jennifer Snow, Jose Casares, Megan Lee, Cynthia Brandt, Joseph Ditre, William Becker
Summary: The Pain and Smoking Study (PASS) is a clinical trial aiming to promote smoking cessation among Veterans with chronic pain through a telephone-delivered cognitive behavioral intervention. Participants are mainly older white males with high smoking rates, fair overall health, and high levels of pain intensity and anxiety.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)
Article
Health Care Sciences & Services
Benjamin A. Howell, Erica A. Abel, Dongchan Park, Sara N. Edmond, Leah J. Leisch, William C. Becker
Summary: The study found significant levels of likely inaccurate OUD diagnoses among veterans with incident OUD diagnoses, with most cases being caused by systems errors. Younger veterans prescribed opioids for pain were more likely to have inaccurate diagnoses. It is important to increase training for clinicians to address clinical errors and insufficient documentation in order to improve accuracy of OUD diagnoses.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Oncology
Shlomit S. Shachar, Allison M. Deal, Katherine E. Reeder-Hayes, Kirsten A. Nyrop, Natalia Mitin, Carey K. Anders, Lisa A. Carey, E. Claire Dees, Trevor A. Jolly, Gretchen G. Kimmick, Meghan S. Karuturi, Raquel E. Reinbolt, JoEllen C. Speca, Hyman B. Muss
JNCI CANCER SPECTRUM
(2020)
Article
Health Care Sciences & Services
William C. Becker, Erin E. Krebs, Sara N. Edmond, Lewei A. Lin, Mark D. Sullivan, Roger D. Weiss, Adam J. Gordon
JOURNAL OF GENERAL INTERNAL MEDICINE
(2020)