Article
Pharmacology & Pharmacy
Jee Yun Kim, Kyun Young Kim, Jeong Yee, Hye Sun Gwak
Summary: This study aimed to construct a risk scoring system for vancomycin-associated acute kidney injury (AKI). A retrospective review of medical records was conducted and potential risk factors were identified. Machine learning methods were used to predict the occurrence of AKI. The developed scoring system showed good predictive performance and can be applied in clinical settings where multiple nephrotoxic agents are used with vancomycin therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Welder Zamoner, Karina Zanchetta Cardoso Eid, Lais Maria Bellaver de Almeida, Isabella Goncalves Pierri, Adriano dos Santos, Andre Luis Balbi, Daniela Ponce
Summary: This study suggests that higher serum concentrations of vancomycin are associated with acute kidney injury in critically ill septic patients, preceding the diagnosis by at least 48 hours. It can be a useful monitoring tool when AUC cannot be used.
Article
Pharmacology & Pharmacy
Pan Kunming, Chen Can, Chen Zhangzhang, Wu Wei, Xu Qing, Ding Xiaoqiang, Li Xiaoyu, Lv Qianzhou
Summary: This study revealed that the incidence of vancomycin-associated acute kidney injury (VA-AKI) in China is 14.3%, and concurrent use of cephalosporins, carbapenems, and piperacillin-tazobactam increases the risk of developing VA-AKI. Full renal recovery is significantly associated with reduced mortality.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chih-Chao Yang, Pei-Hsun Sung, John Y. Chiang, Han-Tan Chai, Chih-Hung Chen, Yi-Ching Chu, Yi-Chen Li, Hon-Kan Yip
Summary: Combined tacrolimus and melatonin therapy was more effective than either single treatment in protecting the kidney from IR injury by suppressing inflammation and oxidative stress.
Review
Immunology
Jianhua Yang, Yuanxiu Gan, Xuanyun Feng, Xiangyu Chen, Shu Wang, Junwei Gao
Summary: This study systematically reviewed and assessed the efficacy and safety of melatonin in preventing acute kidney injury (AKI). The results showed that melatonin did not have a significant effect on reducing the incidence of AKI. More well-designed clinical studies with larger sample size are needed in the future to verify these findings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Ioannis Bellos, Vasilios Pergialiotis, Despina N. Perrea
Summary: This study analyzed biopsy-proven cases of vancomycin nephrotoxicity and found that acute tubulointerstitial nephritis was a major histological pattern associated with a significantly higher risk of permanent renal dysfunction. Fibrosis and tubulitis played important roles in renal prognosis.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Pharmacology & Pharmacy
Fei Mu, Chen Cui, Meng Tang, Guiping Guo, Haiyue Zhang, Jie Ge, Yujia Bai, Jinyi Zhao, Shanshan Cao, Jingwen Wang, Yue Guan
Summary: This study aimed to construct a machine learning framework for stratified predicting and interpreting vancomycin-associated acute kidney injury (AKI). By analyzing the medical records of 724 patients, the study developed risk prediction models for different underlying diseases. The study also identified some underappreciated risk factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Heather D'Amico, Katie L. Wallace, Donna Burgess, David S. Burgess, Sarah Cotner, Ryan Mynatt, Nannan Li, Arnold Stromberg, Jeremy VanHoose
Summary: This study found that monitoring vancomycin treatment using AUC(24) was associated with a decreased risk of acute kidney injury in obese patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Abdulmajeed M. Alshehri, Mohammed Y. Alzahrani, Mohammed A. Abujamal, Mariam H. Abdalla, Shuroug A. Alowais, Osamah M. Alfayez, Majed S. Alyami, Abdulaali R. Almutairi, Omar A. Almohammed
Summary: The study found that combining vancomycin with piperacillin-tazobactam increases the risk of acute kidney injury in adult patients, while combining it with meropenem shows no significant difference. Clinicians should be cautious in using V + PT, especially in patients at high risk of AKI.
Article
Immunology
Weihuang Qiu, Sheng An, Tingjie Wang, Jiaxin Li, Binmei Yu, Zhenhua Zeng, Zhongqing Chen, Bo Lin, Xianzhong Lin, Youguang Gao
Summary: This study finds that ferroptosis exacerbates sepsis-induced acute kidney injury. Melatonin can suppress ferroptosis and alleviate kidney injury by upregulating the Nrf2/HO-1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kunming Pan, Ying Huang, Chenqi Xu, Zhangzhang Chen, Xiaoqiang Ding, Xiaoyu Li, Xialian Xu, Qianzhou Lv
Summary: This large retrospective cohort study reveals the incidence, risk factors, and prognosis of vancomycin-associated acute kidney injury (VA-AKI) in patients with infective endocarditis (IE). The study found that concomitant contrast agents and duration of vancomycin therapy longer than 10.75 days were independent risk factors for VA-AKI in IE patients. Therefore, closer monitoring of kidney function and vancomycin trough concentrations is recommended in these patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Abdullah Tarik Aslan, Tural Pashayev, Osman Dag, Murat Akova
Summary: This study compared the impact of different antibiotic combinations on acute kidney injury (AKI). The results showed that teicoplanin is preferred over vancomycin when combined with TZP to reduce the risk of AKI occurrence. However, there were no significant differences in other aspects such as mortality rates and AKI resolution rates.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Health Care Sciences & Services
Abdullah Tarik Aslan, Murat Akova
Summary: Numerous studies have shown that combination therapy of piperacillin-tazobactam and vancomycin is associated with an increased risk of acute kidney injury. However, the exact mechanisms and causality of this association are still unclear. Although there are limitations in the current studies, preventive measures can be taken to reduce the risk of acute kidney injury when using this combination therapy.
Article
Pharmacology & Pharmacy
Samar F. Darwish, Abdulla M. A. Mahmoud, Sherif S. Abdel Mageed, Al-Aliaa M. Sallam, Mamdouh A. Oraby
Summary: This study investigated the protective effect of the oral antidiabetic agent dapagliflozin (DAPA) on vancomycin-induced acute kidney injury (AKI) in rats. The results showed that pretreatment with DAPA effectively attenuated renal damage and improved renal function in VCM-treated rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Infectious Diseases
Maria H. Rigatto, Pedro Bergo, Giulia Baldissera, Eduarda Beck, Leonardo David, Lucas Santoro, Andressa Barros, Rafael Zanin, Joao I. Budelon Goncalves, Diego Falci, Wolnei Caumo, Alexandre P. Zavascki
Summary: This study compared the effect of melatonin versus placebo on the incidence of acute kidney injury (AKI) in patients treated with polymyxin B. The results showed that initiating melatonin within the first 48 hours of therapy did not reduce the risk of AKI in patients treated with polymyxin B.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Immunology
Palna Mehta, Ronald G. Nahass, Luigi Brunetti
Summary: A systematic review and meta-analysis found that the use of acid-suppression medications (ASMs) during hospitalization was associated with a higher risk of recurrent Clostridioides difficile infection (CDI), especially with proton pump inhibitor (PPI) use. Further studies are needed to clarify the iatrogenic effects of ASMs, and unnecessary PPI use should be discontinued.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Luigi Brunetti, Janaki Vekaria, Peter E. Lipsky, Naomi Schlesinger
Summary: This study aimed to investigate pharmacotherapy use related to gout treatment in U.S. emergency department patients, finding that roughly 30% of patients did not receive anti-inflammatory medication upon discharge and opioids were frequently overused in gout management in the ED. There is an opportunity for further education of healthcare providers regarding gout treatment.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Savanna SanFilippo, Veronique Michaud, Juanqin Wei, Ravil Bikmetov, Jacques Turgeon, Luigi Brunetti
Summary: The study introduced a novel medication risk score (MRS) to evaluate medication regimens of older adults and found that only a small percentage of patients met the criteria, indicating potential for future use on high-risk patients. The MRS was associated with an increased risk of readmission for patients discharged home, highlighting its potential utility in identifying patients at high risk of medication-related iatrogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Savanna San Filippo, Brynna Crovetto, John Bucek, Ronald G. Nahass, Marc Milano, Luigi Brunetti
Summary: This study aimed to evaluate the failure rates of bamlanivimab and casirivimab/imdevimab in COVID-19 treatment and investigate the relationship between treatment timing and efficacy.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
HaYoung Ryu, Sana Mohayya, Thomas Hong, Mansi Modi, Jaehee Yang, Ahmed Abdul Azim, Pinki J. Bhatt, Luigi Brunetti, Navaneeth Narayanan
Summary: This retrospective cohort study evaluated the safety and efficacy of different doses of cefazolin for the treatment of infections in obese patients. The results showed that high-dose cefazolin was safe and well tolerated in patients with high body weight. However, larger studies are needed to confirm the benefit of this dosing strategy.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Emily Abdelmessih, Nandini Patel, Janaki Vekaria, Brynna Crovetto, Savanna SanFilippo, Christopher Adams, Luigi Brunetti
Summary: This meta-analysis compares the impact of AUC-guided dosing strategies with trough-based monitoring on vancomycin-induced nephrotoxicity. The results show that AUC-guided dosing strategies are associated with a significantly lower incidence of kidney injury compared to trough-guided strategies.
Article
Critical Care Medicine
Nandini Patel, Christopher Adams, Luigi Brunetti, Christopher Bargoud, Amanda L. Teichman, Rachel L. Choron
Summary: The study found that procalcitonin (PCT) has limited utility in predicting secondary bacterial pneumonia in critically ill patients with severe COVID-19 pneumonia, as well as in predicting disease severity or mortality outcomes.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Luigi Brunetti, Helene Chapy, Ronald G. G. Nahass, Rebecca Moore, Andrew Wassef, Derek Adler, Edward Yurkow, Leonid Kagan
Summary: The effect of obesity on IgG pharmacokinetics was investigated in a rat model and clinical evidence for an association between body composition and IVIG pharmacokinetic parameters in humans was collected. The pharmacokinetics of human IgG was significantly different between obese and lean rats. In the clinical study, total serum IgG concentration and subtype half-life negatively correlated with BMI and fat mass.
Article
Toxicology
Marshall Yuan, Kelsey Briscese, Thomas S. Hong, Luigi Brunetti
Summary: Drug-induced acute kidney injury (AKI), especially from exposure to antibiotics, has a high prevalence. Natural products rich in active constituents possessing antioxidant properties may be beneficial in reducing the risk of AKI.
CURRENT OPINION IN TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lindsay Brust-Sisti, Nicole Rudawsky, Jimmy Gonzalez, Luigi Brunetti
Summary: SGLT2 inhibitors are a novel class of antidiabetic medications that have shown potential in reducing cardiovascular morbidity, mortality, and hospitalization for heart failure. However, there are varying outcomes and limitations in the use of these drugs in different populations. Future research and clinical experience may lead to expanded use and better understanding of their benefits in patients with heart failure.
Article
Food Science & Technology
Luigi Brunetti, Lujing Wang, Andrew Wassef, Yongjia Gong, Anita Brinker, Brian Buckley, Peter E. E. Lipsky, Patricia Ondar, George Poiani, Liping Zhao, Ah-Ng Kong, Naomi Schlesinger
Summary: This study aims to quantify the major anthocyanins in TC Juice Concentrate (TCJC) and determine the pharmacokinetic and pharmacodynamic parameters of the major anthocyanin cyanidin-3-glucosylrutinoside (C3GR). The study found that C3GR achieves the highest plasma concentration in a dose-dependent manner.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Kiran Deshpande, Keith R. R. Lange, William B. B. Stone, Christine Yohn, Naomi Schlesinger, Leonid Kagan, Albert J. J. Auguste, Bonnie L. L. Firestein, Luigi Brunetti
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces systemic inflammation, resulting in organ damage. This study identifies changes in the expression of drug transporters and metabolizing enzymes in the liver, kidneys, and lungs of infected mice. These findings highlight the importance of considering altered drug disposition and processing in the development of therapeutic compounds.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Review
Pharmacology & Pharmacy
Thomas S. Hong, Amy Hu, Germin Fahim, Evelyn R. Hermes-DeSantis
Summary: This review evaluates emerging therapies for peanut allergy (PA) and their potential role in treating this condition. Oral, epicutaneous, and sublingual immunotherapies have shown promising efficacy, with Palforzia (AR101) and Viaskin Peanut already approved or expected to be approved. The use of adjuvant therapies with immunotherapy has demonstrated improved efficacy and safety. However, the high rates of adverse reactions associated with immunotherapy indicate a need for further research.
JOURNAL OF PHARMACY PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Robyn Stoianovici, Luigi Brunetti, Christopher D. Adams
Summary: Hospitalizations can disrupt patient sleep patterns and contribute to insomnia, leading to a higher risk of altered mental status. This study compared patient-perceived effectiveness of zolpidem versus melatonin in hospitalized patients, with results showing no significant difference in sleep perception between the two medications.
JOURNAL OF PHARMACY PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Aamer Attaar, Juanqin Wei, Luigi Brunetti
Summary: The implementation of a CDI electronic order set was shown to increase prescriber adherence to current IDSA recommendations for CDI management. This not only improved inpatient compliance to guidelines but also enhanced medication-related adherence to guideline recommendations upon discharge.
JOURNAL OF PHARMACY PRACTICE
(2021)