Article
Plant Sciences
Nan Nan, Mu-xin Gong, Qi Wang, Mei-jing Li, Rui Xu, Zhe Ma, Si-hui Wang, Hui Zhao, Yong-song Xu
Summary: This study found that Wuzhuyu decoction (WZYD) can effectively relieve hyperalgesia in chronic migraine (CM) model rats by regulating central and peripheral serotonin (5-HT). WZYD increased 5-HT levels in the brainstem and plasma, decreased calcitonin gene-related peptide, and downregulated inflammatory factors and c-fos expression.
Article
Pharmacology & Pharmacy
Ting Li, Linlin Wang, Linjie Zhang, Baoxia Li, Daohui Wang, Leiming Zhang, Tian Wang, Fenghua Fu
Summary: The study revealed that the antinociceptive effect of RoMS is associated with activating central dopamine D-2 and D-3 receptors, while opioid receptors also play a role in this effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Chun-Sung Sung, Hao-Jung Cheng, Nan-Fu Chen, Shih-Hsuan Tang, Hsiao-Mei Kuo, Ping-Jyun Sung, Wu-Fu Chen, Zhi-Hong Wen
Summary: The natural marine compound aaptamine, isolated from sea sponges, has analgesic effects and can alleviate neuropathic pain. It reduces nociceptive sensitization, allodynia, and hyperalgesia in a rat model of peripheral neuropathy. Additionally, aaptamine downregulates the expression of VEGF, CD31, and LDHA in the spinal cord, and inhibits astrocyte-derived angiogenesis and neuronal LDHA expression. These findings suggest that aaptamine has potential as an analgesic agent for neuropathic pain.
Article
Integrative & Complementary Medicine
Wang Feng-jiao, Shi She, Wang Yong-qiang, Wang Ke, Fan Shen-dong, Zhang Ya-nan, Feng Chen-chen, Ju Zi-yong
Summary: The study found that electroacupuncture treatment can alleviate the symptoms of oxaliplatin-induced peripheral neuropathy (OIPN) in rats, and this effect may be mediated by restoring the Nrf2/HO-1 signaling pathway.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Geriatrics & Gerontology
Yiyi Shi, Qinxue Dai, Binbin Ji, Luping Huang, Xiuxiu Zhuang, Yunchang Mo, Junlu Wang
Summary: This study found that electroacupuncture pretreatment upregulated the expression of A1 receptor in the rat hippocampus, reversed cognitive impairment, and played a role in neuroprotection after focal cerebral ischemia. Using A1 receptor agonist CCPA, antagonist DPCPX, and A1 short interfering RNA further confirmed the important role of A1 receptor in this process.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Lu Liu, Xiao-Bai Xu, Zheng-Yang Qu, Luo-Peng Zhao, Claire-Shuiqing Zhang, Zhi-Juan Li, Tian-Li Lyu, Xue-Fei Wang, Xiang-Hong Jing, Bin Li
Summary: The study shows that 5-HT7R plays a role in the antihyperalgesic effects of electroacupuncture by regulating PKA and ERK1/2 signaling pathways, reducing neurogenic inflammatory pain caused by migraines. Electroacupuncture increases pain thresholds and alleviates neuronal hyperexcitability in the trigeminal nucleus caudalis.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Hui-Hui Xiao, Yu-Xin Zhu, Lu Lu, Li-Ping Zhou, Christina Chui-Wa Poon, Chi-On Chan, Li-Jing Wang, Sisi Cao, Wen-Xuan Yu, Ka-Ying Wong, Daniel Kam-Wah Mok, Man-Sau Wong
Summary: This study found that the lignan-rich fraction from Sambucus williamsii Hance modulates bone metabolism via serotonin. The treatment with SWCA alleviated bone loss and decreased serum serotonin levels, which were negatively correlated with bone mineral density. It inhibited the protein expression of TPH-1 in the colon and reversed the gene and protein expressions of FOXO1 and ATF4 in the femur. Furthermore, SWCA treatment also modulated the composition of several genera related to bone mineral density.
Article
Cell Biology
Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Cristina Tassorelli
Summary: This study reveals the association between activation of the CGRP pathway and persistent activation of inflammatory pathways in chronic migraine, accompanied by the presence of hyperalgesia. These findings are important for understanding the mechanisms underlying chronic migraine.
Article
Immunology
Shunqin Fan, Xijun Wang, Ning Gao, Songli Wei
Summary: In a rat model, electroacupuncture pretreatment was found to improve learning and memory deficits induced by recurrent propofol exposure. It also enhanced hippocampal synaptic plasticity, activated the pCREB/BDNF pathway, and inhibited neuronal apoptosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Neurosciences
Kimbra A. Edwards, Susan L. Zup
Summary: The excitability and susceptibility to excitotoxic damage of neurons may be sex-specific, with males being more prone to hyperexcitable neuronal networks, leading to increased seizure susceptibility. Serotonin (5-HT) plays a crucial role in regulating neuronal excitability and seizure behavior, and sex differences during the perinatal period can affect these processes.
Article
Pharmacology & Pharmacy
Fanrong Yao, Abdel A. Abdel-Rahman
Summary: Activation of CB1R in the RVLM increases blood pressure and heart rate in rats, but this response is modulated by ovarian sex hormones, particularly E-2. E-2 attenuates the CB1R-mediated cardiovascular response by dampening neuroexcitation and oxidative stress in the RVLM.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jie Cheng, Weimin Li, Ying Wang, Qing Cao, Ying Ni, Wenyi Zhang, Jiabao Guo, Binglin Chen, Yaning Zang, Yi Zhu
Summary: The study suggests that electroacupuncture and fecal microbiota transplantation treatment can improve intestinal function and morphology in rats with spinal cord injury by reshaping intestinal microbiota, regulating metabolites, and 5-HT system expression.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Anesthesiology
Sumire Ishiyama, Yasushi Shibata, Satoshi Ayuzawa, Akira Matsushita, Akira Matsumura, Eiichi Ishikawa
Summary: This study aimed to investigate the effect of C2 peripheral nerve field stimulation with electroacupuncture (EA-C2-PNfS) on functional connectivity (FC) in patients with migraine and to elucidate the underlying mechanism. The results showed that FC in patients with migraine without aura (MWoA) significantly changed after EA-C2-PNfS, indicating that EA-C2-PNfS can improve migraine headache by modifying the connectivity between pain-related brain regions.
Article
Biochemistry & Molecular Biology
Adriana Della Pietra, Rashid Giniatullin, Juha R. Savinainen
Summary: This study suggests using the endogenous cannabinoid system to alleviate migraine pain by inhibiting enzymes degrading endocannabinoids for analgesic effects. The activity of MAGL was significantly higher than FAAH in trigeminal ganglia, suggesting it as a priority target for blocking peripheral mechanisms of migraine pain. In the central nervous system, both MAGL and FAAH could serve as potential targets for reducing migraine-related enhanced cortical excitability and pain transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yuan Kang, Yuan Gao, Ximeng Li, Xinwei Guo, Zhuangzhuang Liu, Wenjing Li, Jianhe Wei, Yun Qi
Summary: This study aims to elucidate the antipyretic characteristics and mechanisms of the traditional Chinese medicine "Bupleuri Radix" (BC). It was found that the water extract of BC can reduce fever in rats and suppress the production of TNF-alpha. Additionally, BC can also inhibit complement activation both in vitro and in vivo. Through these mechanisms, BC may exert its antipyretic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Neurosciences
Zhengyang Qu, Lu Liu, Yi Yang, Luopeng Zhao, Xiaobai Xu, Zhijuan Li, Yupu Zhu, Xianghong Jing, Xiaoyu Wang, Claire Suiqing Zhang, Marc Fisher, Bin Li, Linpeng Wang
Article
Plant Sciences
Shan He, Fangqiao Lyu, Lixia Lou, Lu Liu, Songlin Li, Johannes Jakowitsch, Yan Ma
Summary: Panax quinquefolius saponins (PQS) exhibit anti-cancer activity in human prostate cancer cells by inhibiting proliferation and promoting apoptosis. TMEM79 and ACOXL may serve as novel biomarkers for prostate cancer diagnosis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Clinical Neurology
Xue-Juan Yang, Lu Liu, Zi-Liang Xu, Ya-Jie Zhang, Da-Peng Liu, Marc Fishers, Lan Zhang, Jin-Bo Sun, Peng Liu, Xiao Zeng, Lin-Peng Wang, Wei Qin
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Zhengyang Qu, Lu Liu, Luopeng Zhao, Xiaobai Xu, Zhijuan Li, Yupu Zhu, Chen Zhang, Xianghong Jing, Xiaoyu Wang, Bin Li, Claire Shuiqing Zhang, Marc Fisher, Linpeng Wang
JOURNAL OF PAIN RESEARCH
(2020)
Article
Clinical Neurology
Luopeng Zhao, Lu Liu, Xiaobai Xu, Zhengyang Qu, Yupu Zhu, Zhijuan Li, Jingxia Zhao, Linpeng Wang, Xianghong Jing, Bin Li
JOURNAL OF PAIN RESEARCH
(2020)
Review
Clinical Neurology
Mina Wang, Lu Liu, Claire Shuiqing Zhang, Zehuan Liao, Xianghong Jing, Marc Fishers, Luopeng Zhao, Xiaobai Xu, Bin Li
JOURNAL OF PAIN RESEARCH
(2020)
Article
Clinical Neurology
Jiangyan Wei, Lu Liu, Zhijuan Li, Tianli Lyu, Luopeng Zhao, Xiaobai Xu, Yine Song, Yidan Dai, Bin Li
Summary: Fire needling acupuncture can alleviate articular cartilage damage and reduce pain in knee osteoarthritis (KOA) by modulating macrophage polarization.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Clinical Neurology
Lu Liu, Qiuyi Chen, Jiwei Yang, Weijuan Gang, Luopeng Zhao, Tianli Lyu, Xianghong Jing, Claire Shuiqing Zhang, Bin Li
Summary: This study aims to assess the effectiveness and safety of fire needling acupuncture on acute herpes zoster (HZ) and provide new evidence to guide acupuncture interventions for acute HZ in the future.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Neurosciences
Ying Chen, Yuhan Liu, Yine Song, Shaoru Zhao, Bin Li, Jingqing Sun, Lu Liu
Summary: Acupuncture is commonly used for the treatment of migraines and has been shown to decrease pain intensity, duration, and emotional comorbidity. The mechanisms of acupuncture in treating migraines involve modulation of neurotransmitters, immune cells, and neuroplasticity. Further research is needed to fully understand the clinical effectiveness and underlying mechanisms of acupuncture for migraines.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Lu Liu, Claire-Shuiqing Zhang, Hui-Lin Liu, Fan He, Tian-Li Lyu, Lin Zeng, Luo-Peng Zhao, Mi-Na Wang, Zheng-Yang Qu, Li-Min Nie, Jia Guo, Xiao-Zhe Zhang, Yong-Hui Lu, Ke-Lun Wang, Bin Li, Xiang-Hong Jing, Lin-Peng Wang
Summary: This study indicates that acupuncture can reduce the number of migraine days experienced by patients with menstruation-related migraine compared to medication. The preventive effect of acupuncture treatment can be sustained for six cycles for patients who received the treatment over three cycles.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Lu Liu, Weizheng Li, Linpeng Wang, Pengyun Gong, Tianli Lyu, Dapeng Liu, Yajie Zhang, Yijie Guo, Xiang Liu, Min Tang, Hongke Hu, Chao Liu, Bin Li
Summary: This study utilized proteomic and metabolomic profiling to reveal that acupuncture treatment can significantly alter metabolic pathways related to migraine, involving energy metabolism and amino acid metabolism. These findings contribute to understanding the pathophysiological changes in migraine and the mechanism of acupuncture treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jiahui Hong, Jingqing Sun, Liping Zhang, Zhongjian Tan, Ying Chen, Qiuyi Chen, Yupu Zhu, Yuhan Liu, Liying Zhu, Lin Zeng, Yazhuo Kong, Bin Li, Lu Liu
Summary: This study aims to investigate the neural mechanism of acupuncture in treating MWoA and predict its treatment effects using machine learning technology.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Mina Wang, Xiaobai Xu, Bingcong Zhao, Lu Liu, Luopeng Zhao, Fan Zhang, Xu Ji, Fang Yuan, Qiuyu Xia, Shaosong Wang, Wei Tian, Linpeng Wang, Bin Li
Summary: This is a study protocol to investigate the effectiveness of different frequencies of fire needling therapy in knee osteoarthritis (KOA) patients. The trial will recruit 90 participants and randomly assign them to high-frequency group, low-frequency group, or positive control group. The primary outcome is the proportion of participants achieving a minimal clinically important difference in pain and function scores at Week 6 compared with Week 0. This trial aims to provide reliable evidence for the effectiveness of fire needling therapy in KOA.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Neuroimaging
Lu Liu, Tian-Li Lyu, Ming-Yang Fu, Lin-Peng Wang, Ying Chen, Jia-Hui Hong, Qiu-Yi Chen, Yu-Pu Zhu, Zhong-Jian Tan, Da-Peng Liu, Zi-Wei Chen, Ya-Zhuo Kong, Bin Li
Summary: This study aimed to investigate the brain mechanism underlying acupuncture for migraine without aura (MWoA). Through the analysis of resting-state functional magnetic resonance imaging (fMRI) and clinical data, it was found that the real acupuncture group showed significant improvement in headache severity, headache impact, and health-related quality of life compared to the sham acupuncture group. Acupuncture may improve migraine symptoms by regulating the functional connectivity of relevant brain regions.
NEUROIMAGE-CLINICAL
(2022)
Article
Medicine, Research & Experimental
Yuanjie Gao, Lu Liu, Bin Li, Jing Guo, Huilin Liu, Shaosong Wang, Fan Zhang, Xu Ji, Yuanbo Fu, Yizhan Wang, Jingqing Sun, Fang Yuan
