Article
Biochemistry & Molecular Biology
Dmitry Senko, Anna Gorovaya, Elena Stekolshchikova, Nickolay Anikanov, Artur Fedianin, Maxim Baltin, Olga Efimova, Daria Petrova, Tatyana Baltina, Mikhail A. Lebedev, Philipp Khaitovich, Anna Tkachev
Summary: The study assessed blood lipidome alterations in a rat sciatic nerve crush injury model and found delayed systematic alterations in fatty acid metabolism after nerve injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Liangfu Jiang, Xingyu Ouyang, Dupiao Zhang, Gang Wang, Zhe Zhang, Wei Wang, Hede Yan
Summary: This study presents a Gel-Ppy modified nerve conduit with excellent biocompatibility and conductivity, and evaluates its performance in promoting nerve regeneration in vitro and in vivo. The results demonstrate that Gel-Ppy modified nerve conduit can significantly enhance Schwann cell proliferation, contribute to Schwann cell regeneration in vivo, and improve axon diameters and myelin sheath thickness, leading to the amelioration of muscle atrophy, nerve conduction, and motor function recovery. Further investigation indicates that the Gel-Ppy conduit facilitates nerve regeneration by upregulating the Rap1 pathway to induce neurite outgrowth. Therefore, Gel-Ppy modified nerve conduit can provide a favorable microenvironment for nerve regeneration and be popularized as a novel therapeutic strategy for peripheral nerve injury.
Article
Rehabilitation
Kubra Neslihan Kurt Oktay, Pinar Akpinar, Feyza Unlu Ozkan, Ilknur Aktas, Yasemin Ersoy Canillioglu, Gozde Erkanli Senturk
Summary: This study demonstrates the potential of alpha lipoic acid to accelerate nerve healing in rats with sciatic nerve crush injury. The use of alpha lipoic acid resulted in regeneration of muscle and nerve connective tissues, improvement of nerve structures, suppression of inflammation, and reduction in degeneration of myelinated nerve fibers.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Plant Sciences
Chih-Yuan Ko, Chung-Hsin Wu, Thi Kim Ngan Nguyen, Li-Wen Chen, James Swi-Bea Wu, Wen-Chung Huang, Szu-Chuan Shen
Summary: This study investigated the effect of Ficus formosana extract (FFE) on diabetic peripheral neuropathy (DPN) in ovariectomized diabetic mice. The results showed that FFE improved DPN symptoms by suppressing oxidative damage, alleviating pain responses, and reducing nerve abnormalities.
Article
Neurosciences
Rahul Shankar Rao Rayilla, M. U. R. Naidu, Phanithi Prakash Babu
Summary: This study presents a surgical approach to induce demyelination in the rat sciatic nerve, followed by remyelination after Teriflunomide (TF) treatment. Histology and immunostaining reveal demyelination or myelin loss after sciatic nerve injury, with no self-recovery. The rotarod test confirms the motor function loss in nerve-damaged rats. Transmission electron microscopy shows axonal atrophy and inter-axonal gaps in these rats. TF administration restores motor function, repairs axonal atrophy with inter-axonal spaces, and promotes myelin secretion or remyelination. These findings demonstrate the potential of the surgical procedure and TF treatment in inducing and repairing demyelination.
Article
Cell & Tissue Engineering
Maki Ando, Ryosuke Ikeguchi, Tomoki Aoyama, Mai Tanaka, Takashi Noguchi, Yudai Miyazaki, Shizuka Akieda, Koichi Nakayama, Shuichi Matsuda
Summary: The study compared the long-term safety and nerve regeneration of Bio3D conduit with artificial nerve conduit and autologous nerve transplantation in treating rat sciatic nerve defect. Results showed that the Bio3D group exhibited significantly better nerve regeneration compared to the silicon group, and there was no significant difference between the Bio3D group and the nerve autograft group in all endpoints.
CELL TRANSPLANTATION
(2021)
Review
Health Care Sciences & Services
Maximilian Mayrhofer-Schmid, Tess T. Klemm, Martin Aman, Ulrich Kneser, Kyle R. Eberlin, Leila Harhaus, Arne H. Boecker
Summary: Wrapping peripheral nerves can prevent scar tissue formation and adhesions, but the optimal material and technique have yet to be determined. Further research is needed to identify the most effective nerve wrapping method for clinical practice.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell & Tissue Engineering
Young Ho Shin, Hee-Woong Yun, Suk Young Park, Soon Jin Choi, In-Su Park, Byoung-Hyun Min, Jae Kwang Kim
Summary: GA-crosslinked CAM films, after successful fabrication, maintain the microstructure and chemical composition of ECM while improving physical properties. In vitro studies show effective decellularization and inhibition of cell adhesion and proliferation, with no cytotoxicity observed. In vivo experiments demonstrate reduced peri-neural fibrosis and adhesion, increased myelinated axons, and improved nerve functional recovery in CAM film-treated rats compared to controls.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Cell Biology
Cameron L. Ghergherehchi, Jaimie T. Shores, Joseph Alderete, Erik K. Weitzel, George D. Bittner
Summary: Complete transection of peripheral mixed nerves immediately leads to loss of sensory perception, muscle contractions, and voluntary behavior, which can be restored within minutes by PEG-fusion. The inclusion of 0.5% MB in the PEG-fusion protocol significantly improves the rate and extent of behavioral recovery compared to PEG alone, making it a promising addition to future human clinical trials for peripheral nerve injuries.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Szu-Han Chen, Chia-Ching Wu, Sheng-Che Lin, Wan-Ling Tseng, Tzu-Chieh Huang, Anjali Yadav, Fu- Lu, Ya-Hsin Liu, Shau-Ping Lin, Yuan-Yu Hsueh
Summary: Peripheral compressive neuropathy causes significant neuropathic pain, muscle weakness, and prolonged neuroinflammation. The gold standard treatment of surgical decompression has suboptimal outcomes with a high recurrence rate. The study highlights the need for further research on distinct neuropathologic patterns and genetic signatures after nerve decompression for improved therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Zonghuan Wang, Yibing Wu, Yang Xiang, Marie Beatrix Kruth, Peng Wei, Guangli Dai, Kedi Xu, Jun Yin, Yong Huang
Summary: The study illustrates that nerve conduits with micro-grooved inner textures significantly improve peripheral nerve regeneration, leading to enhanced nerve tissue repair efficiency. These conduits show similar repair capacity to autografts, demonstrating the potential for improved nerve tissue engineering strategies.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Neurosciences
Adrien Rapeaux, Timothy G. Constandinou
Summary: This paper describes experiments conducted on rat sciatic nerves to measure the recovery speed of A fibres from block carryover. The findings demonstrate the carryover property of high-frequency nerve block and its potential significance in reducing power requirements for stimulation in clinical applications.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Integrative & Complementary Medicine
Lu Yin, Yun An, Xiao Chen, Hui-xin Yan, Tao Zhang, Xin-gang Lu, Jun-tao Yan
Summary: This study investigated the effect of local vibration therapy with different amplitudes on the recovery of nerve function in rats with sciatic nerve injury. The results showed that medium amplitude vibration therapy could promote nerve function recovery and was associated with the proliferation of Schwann cells and the activation of the ERK1/2 and Akt signaling pathways.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Neurosciences
Nikhil S. Chandra, Weston M. McCarron, Ying Yan, Luis C. Ruiz, Eric G. Sallinger, Nathan K. Birenbaum, Harold Burton, Leonard Green, Daniel W. Moran, Wilson Z. Ray, Matthew R. MacEwan
Summary: The study investigated the viability of the MSE as a sensory feedback interface through a rat sciatic nerve and behavioral model, finding that the MSE can elicit sensory percepts at low current levels and laying the groundwork for future experiments to study other devices, stimulus parameters, and task paradigms.
FRONTIERS IN NEUROSCIENCE
(2021)