Article
Rheumatology
Karin Lundberg, Ling Qin, Cecilia Aulin, Willem Evert van Spil, Marc P. Maurits, Rachel Knevel
Summary: This study examined the usability and acceptance of Rheumatic?- an online symptom-checker (SC) for rheumatology. The results showed that most participants found Rheumatic? useful, felt that it helped them describe their symptoms well, and would recommend it to others. However, some participants felt that there were too many questions. Overall, Rheumatic? shows promising potential in the field of rheumatology.
Article
Medical Laboratory Technology
Paola Galozzi, Daniela Basso, Mario Plebani, Andrea Padoan
Summary: Artificial intelligence (AI) has become a valuable tool for improving diagnosis, risk stratification, and personalized medicine in rheumatic diseases. Machine learning algorithms can analyze large amounts of laboratory data to classify patients, determine disease subtypes, and discover biomarkers. This review provides examples of machine learning models using laboratory data and insights into their strengths and limitations for specific rheumatic diseases.
CLINICA CHIMICA ACTA
(2023)
Article
Rheumatology
Claudia Sengler, Sascha Eulert, Kirsten Minden, Martina Niewerth, Gerd Horneff, Jasmin Kuemmerle-Deschner, Caroline Siemer, Rainer Berendes, Hermann Girschick, Regina Huehn, Michael Borte, Anton Hospach, Wolfgang Emminger, Jakob Armann, Ariane Klein, Tilmann Kallinich
Summary: This study investigated the clinical manifestations, course, and outcome of SARS-CoV-2 infection among children and adolescents with rheumatic and musculoskeletal diseases. The majority of patients had a mild course of infection with good outcomes, and the infection did not significantly impact the disease activity of the underlying condition in most cases.
Letter
Genetics & Heredity
Ameenat Lola Solebo, Pirro Hysi, Lisanne Andra Horvat-Gitsels, Jugnoo Sangeeta Rahi
Summary: The necessity-driven organizational change in healthcare after the pandemic has led to the adoption of innovations in managing and processing health data. However, there is a risk of rare diseases being left behind unless the clinical and research communities engage with the challenges and opportunities of health data informatics. Recommendations for addressing the challenges in using and reusing rare disease data include workforce education, harmonization of taxonomy, and creating an inclusive health data environment where rare disease managers have a crucial role to play.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Rheumatology
Chiara Tani, Dina Zucchi, Elisa Bellis, Mehret Birru Talabi, Charlotte Frise, Guilherme Ramires de Jesus, Hege Svean Koksvik, Gema Maria Lledo, Arsene Mekinian, Diana Marinello, Ilaria Palla, Puja Mehta, Luis Saez Comet, Shoela Shaimaa, Hieronymus T. W. Smeele, Rosaria Talarico, Antonio Brucato, Munther Khamashta, Yehuda Shoenfeld, Angela Tincani, Marta Mosca
Summary: An international survey was conducted to map existing organizational care pathways in clinical centers of expertise that care for pregnant women affected by rare and complex connective tissue diseases (rcCTDs). The survey collected answers from 69 centers in 21 countries, revealing the involvement of multidisciplinary teams in patient care and the lack of attention given to specific rcCTDs diseases in some centers. Additionally, variations were found in pre-pregnancy care, pregnancy monitoring protocols, and access to therapies during pregnancy.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Christos Grigoroglou, Kieran Walshe, Evangelos Kontopantelis, Jane Ferguson, Gemma Stringer, Darren Ashcroft, Thomas Allen
Summary: This study aimed to quantify and describe the use of locum doctors in NHS trusts in England from 2019 to 2021. The results showed significant variations in locum use among different trusts, with lower-rated and smaller trusts using locums more intensively. The study also highlighted a growing demand for locum doctors, as evidenced by the increasing number of unfilled shifts.
Article
Anesthesiology
Alexander J. Fowler, M. A. Hussein Wahedally, Tom E. F. Abbott, Melanie Smuk, John R. Prowle, Rupert M. Pearse, David A. Cromwell
Summary: One in four surgical patients has a chronic disease with an associated 10-fold increase in risk of postoperative death. Two-thirds of all deaths after surgery occur among patients with high-risk diseases (cancer, cardiac failure, liver disease, dementia).
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Immunology
Andre Pontes-Silva
Summary: This review investigates the use of nailfold videocapillaroscopy in idiopathic inflammatory myopathies and suggests its potential as a promising diagnostic tool and biomarker. Large-scale studies are needed to further explore its associations with clinical and laboratory parameters in different subtypes of idiopathic inflammatory myopathies.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Sebastian Eduardo Sattui, Jean W. Liew, Kevin Kennedy, Emily Sirotich, Michael Putman, Tarin T. Moni, Akpabio Akpabio, Deshire Alpizar-Rodriguez, Francis Berenbaum, Inita Bulina, Richard Conway, Aman Dev Singh, Eimear Duff, Karen L. Durrant, Tamer A. Gheita, Catherine L. Hill, Richard A. Howard, Bimba F. Hoyer, Evelyn Hsieh, Lina El Kibbi, Adam Kilian, Alfred Hyoungju Kim, David F. L. Liew, Chieh Lo, Bruce Miller, Serena Mingolla, Michal Nudel, Candace A. Palmerlee, Jasvinder A. Singh, Namrata Singh, Manuel Francisco Ugarte-Gil, John Wallace, Kristen J. Young, Suleman Bhana, Wendy Costello, Rebecca Grainger, Pedro M. Machado, Philip C. Robinson, Paul Sufka, Zachary S. Wallace, Jinoos Yazdany, Carly Harrison, Maggie Larche, Mitchell Levine, Gary Foster, Lehana Thabane, Lisa G. Rider, Jonathan S. Hausmann, Julia F. Simard, Jeffrey A. Sparks
Summary: Among adults with systemic rheumatic disease who received COVID-19 vaccination, most patients were willing to temporarily discontinue disease-modifying antirheumatic drugs (DMARDs) to improve vaccine efficacy. Patient-reported adverse events were typical of those reported in the general population, and the relatively low frequency of rheumatic disease flare requiring medication changes was reassuring.
Article
Rheumatology
Joelle W. S. Tiendrebeogo, Fulgence Kabore, Charles Sougue, Virginie Sankara, Enselme Zongo, Binta Savadogo, Aida Abassiri, Ismael Ayouba-Tinni, Aboubakar Ouedraogo, Nadege W. Yameogo, Dieu-Donne Ouedraogo
Summary: The aim of this study was to examine the epidemiological characteristics of rheumatic conditions in a cohort of 23,550 patients in Ouagadougou, Burkina Faso. The study found that degenerative osteoarthropathies were the most common presentation, followed by tendinopathies and chronic inflammatory rheumatism. The study also confirmed the scarcity of conditions such as systemic lupus erythematosus, psoriatic arthritis, and ankylosing spondylitis in this cohort.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Jin Kyun Park, Eun Bong Lee, Kichul Shin, Yoon-Kyoung Sung, Tae Hwan Kim, Seong-Ryul Kwon, Myeung Su Lee, Seung-Jae Hong, Byoong Yong Choi, Shin-Seok Lee, Han Joo Back
Summary: COVID-19 vaccines are considered safe and effective for patients with autoimmune inflammatory rheumatic disease (AIIRD). It is important for rheumatologists to play a leading role in educating and vaccinating these patients, while also adjusting their treatment regimens to optimize vaccine response.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Rheumatology
Fatemah Abutiban, Khulood Saleh, Sawsan Hayat, Hoda Tarakmah, Adeeba Al-Herz, Aqeel Ghanem
Summary: A study found that the use of mycophenolate mofetil and rituximab is significantly associated with poorer outcomes in patients with SARS-CoV-2 infection. These agents are linked to longer hospital stays and severe COVID-19 outcomes. The data from the COVID-19 Global Rheumatology Alliance registry revealed that these drugs may have varying risks of unfavorable clinical outcomes in IRD patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Nerea Moreno-Ruiz, Oscar Lao, Juan Ignacio Arostegui, Hafid Laayouni, Ferran Casals
Summary: For some patients with rare disorders, a clear genetic diagnosis is still lacking even after whole-exome or whole-genome sequencing, which presents challenges in treatment and genetic counseling. Considering digenic inheritance as an alternative explanation for the genetic basis of the disease may be relevant. Therefore, establishing a framework to evaluate the significance of digenic combinations is necessary.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Rheumatology
Anja Strangfeld, Martin Schafer, Milena A. Gianfrancesco, Saskia Lawson-Tovey, Jean W. Liew, Lotta Ljung, Elsa F. Mateus, Christophe Richez, Maria J. Santos, Gabriela Schmajuk, Carlo A. Scire, Emily Sirotich, Jeffrey A. Sparks, Paul Sufka, Thierry Thomas, Laura Trupin, Zachary S. Wallace, Sarah Al-Adely, Javier Bachiller-Corral, Suleman Bhana, Patrice Cacoub, Loreto Carmona, Ruth Costello, Wendy Costello, Laure Gossec, Rebecca Grainger, Eric Hachulla, Rebecca Hasseli, Jonathan S. Hausmann, Kimme L. Hyrich, Zara Izadi, Lindsay Jacobsohn, Patricia Katz, Lianne Kearsley-Fleet, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
Summary: Factors associated with COVID-19-related death in people with rheumatic diseases include age, sex, comorbidities, disease activity, and specific medications. Adequate disease control with disease-modifying anti-rheumatic drugs (DMARDs) without increasing glucocorticoid dosages is important, while caution may be required with certain medications such as rituximab and sulfasalazine.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Glen S. Hazlewood, Jordi Pardo Pardo, Cheryl Barnabe, Orit Schieir, Claire E. H. Barber, Sasha Bernatsky, Ines Colmegna, Carol Hitchon, Mark Loeb, Dominik Mertz, Laurie Proulx, Dawn P. Richards, Rosie Scuccimarri, Peter Tugwell, Holger J. Schunemann, Reza D. Mirza, Alan L. Zhou, Roko P. A. Nikolic, Megan Thomas, Helena Chase, Maede Ejaredar, Robby Nieuwlaat
Summary: The Canadian Rheumatology Association developed guidance on the use of COVID-19 vaccines in patients with autoimmune rheumatic diseases (ARD), with a recommendation to use COVID-19 vaccination in persons with ARD. The panel unanimously agreed that the potential health benefits of vaccination outweigh the potential harms in people with ARDs, although the recommendation was graded as conditional due to low or very low certainty of the evidence. The recommendation will be updated over time as new evidence emerges.
JOURNAL OF RHEUMATOLOGY
(2021)
