Article
Clinical Neurology
Nicola Alessandro Nasuelli, Fabiola De Marchi, Michela Cecchin, Irene De Paoli, Susanna Onorato, Roberto Pettinaroli, Giovanni Savoini, Laura Godi
Summary: This paper describes a case of Guillain-Barre syndrome following vaccination with ChAdOx1 nCoV-19 and highlights the importance of pharmacovigilance. Further reports are needed to evaluate the potential correlation between these two events.
NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Caterina Francesca Bagella, Davide G. Corda, Pietro Zara, Antonio Emanuele Elia, Elisa Ruiu, Elia Sechi, Paolo Solla
Summary: This study reported cases of Guillain-Barre syndrome after COVID-19 vaccination, highlighting the need for close monitoring in these patients after the acute phase to exclude chronic evolution of the disease.
Article
Clinical Neurology
Aaron de Souza, M. Oo, Pradeep Giri
Summary: Rare autoimmune neurological events have been reported during mass vaccination, and this study reports four cases of chronic inflammatory demyelinating polyneuropathy (CIDP) following vaccination, highlighting the potential relationship between vaccination and the development of CIDP.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Selia Chowdhury, Samia Chowdhury
Summary: This study focuses on the association between COVID-19 vaccination and Guillain-Barre syndrome (GBS). A total of 42 case reports from 16 different countries were analyzed. Clinical features observed in the case reports included back pain, facial diplegia, weakness, and paresthesia. Diagnostic studies primarily involved cerebrospinal fluid (CSF) analysis and electromagnetic studies. Treatment options included intravenous immunoglobulin (IVIG), plasmapheresis, and steroids. Further studies are needed to explore the causative links in this correlation and gain a better understanding of the relationship.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: In a population-based study in the UK, the BNT162b2 vaccine showed higher efficacy than the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection and hospitalization for COVID-19, but there was no significant difference in the risk of death from COVID-19.
Article
Immunology
Margherita Bellucci, Francesco Germano, Stefano Grisanti, Chiara Castellano, Francesco Tazza, Emanuela Maria Mobilia, Davide Visigalli, Giovanni Novi, Federico Massa, Silvia Rossi, Paolo Durando, Corrado Cabona, Angelo Schenone, Diego Franciotta, Luana Benedetti
Summary: This article reports a case in which a patient developed GBS symptoms after COVID-19 infection, recovered after treatment, but experienced a recurrence of GBS after receiving the COVID-19 vaccine. Based on this case and previous observations, there may be a possible causal link between SARS-CoV-2 and GBS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
S. A. Madhi, V Baillie, C. L. Cutland, M. Voysey, A. L. Koen, L. Fairlie, S. D. Padayachee, K. Dheda, S. L. Barnabas, Q. E. Bhorat, C. Briner, G. Kwatra, K. Ahmed, P. Aley, S. Bhikha, J. N. Bhiman, A' E. Bhorat, J. du Plessis, A. Esmail, M. Groenewald, E. Horne, S-H Hwa, A. Jose, T. Lambe, M. Laubscher, M. Malahleha, M. Masenya, M. Masilela, S. McKenzie, K. Molapo, A. Moultrie, S. Oelofse, F. Patel, S. Pillay, S. Rhead, H. Rodel, L. Rossouw, C. Taoushanis, H. Tegally, A. Thombrayil, S. van Eck, C. K. Wibmer, N. M. Durham, E. J. Kelly, T. L. Villafana, S. Gilbert, A. J. Pollard, T. de Oliveira, P. L. Moore, A. Sigal, A. Izu
Summary: The ChAdOx1 nCoV-19 vaccine did not provide significant protection against mild-to-moderate Covid-19 caused by the B.1.351 variant, with an efficacy of 10.4%. The incidence of serious adverse events was balanced between the vaccine and placebo groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Jer-Hwa Chang, Jeng-Fong Chiou, Ching-Sheng Hung, Ming-Che Liu, Hui-Wen Chang, Shiao-Ya Hong, Cheng-Yi Wang, Yi-Ling Lin, Yi-Chen Hsieh, Chi-Li Chung, Ying-Shih Su, Shu-Tai Shen Hsiao, Doresses Liu, Jian-Jong Liang, Chun-Che Liao, Chih-Shin Chang, Kevin Shu-Leung Lai, Han-Chuan Chuang, Ko-Ling Chien, Wei-Ciao Wu, Yuan-Chii G. Lee, Sey-En Lin, Yung-Kang Shen, Chiung-Fang Hsu, Jude Chu-Chun Wang, Shih-Hsin Hsiao
Summary: The ChAdOx1 nCoV-19 vaccine elicits a robust humoral immune response against SARS-CoV-2 in Taiwanese recipients after standard prime-boost vaccination. The vaccine is well-tolerated, and antibody levels are associated with factors such as age, gender, and body weight index.
Review
Biotechnology & Applied Microbiology
Hsin-Yu Lee, Wan-Ching Lien
Summary: This article reports two cases of Guillain-Barre syndrome (GBS) following COVID-19 vaccination and reviews relevant literature. The study found that patients who received the AstraZeneca adenovirus vector vaccine had higher incidence of GBS and a greater need for mechanical ventilation. However, accurate estimation of the incidence cannot be achieved through case reports alone. Therefore, population-based data should be used to determine the true rates of GBS following COVID-19 vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Review
Immunology
Naim Mahroum, Noy Lavine, Aviran Ohayon, Ravend Seida, Abdulkarim Alwani, Mahmoud Alrais, Magdi Zoubi, Nicola Luigi Bragazzi
Summary: Despite concerns, vaccines have proven efficacy and contribute greatly to global health. This review focuses on the immune and autoimmune adverse events following immunization (AEFIs) of COVID-19 vaccines, highlighting the rare but worrisome cases. By addressing the concerns and presenting the low occurrence rate of AEFIs, it aims to alleviate vaccine hesitancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Frederic Zuhorn, Tilmann Graf, Randolf Klingebiel, Wolf-Rudiger Schabitz, Andreas Rogalewski
Summary: The global COVID-19 pandemic has caused millions of infections and deaths worldwide, leading to unprecedented efforts in vaccine development. The use of corticosteroids for immunosuppressive therapy has shown efficacy in patients with postvaccinal encephalitis.
ANNALS OF NEUROLOGY
(2021)
Article
Immunology
Chavin D. Gopaul, Dale Ventour, Davlin Thomas
Summary: Vaccine hesitancy due to safety concerns hampers vaccination campaigns. A study conducted among healthcare worker recipients of the ChAdOx1 nCoV-19 vaccine showed that systemic symptoms declined significantly 48 h after the second dose, with younger recipients more likely to report symptoms compared to older recipients. Females were more likely to report certain symptoms compared to males after both doses.
Article
Immunology
Jinnam Kim, Changhyup Kim, Jung Ah Lee, Se Ju Lee, Ki Hyun Lee, Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon-Sup Yeom, Young Goo Song, Jun Yong Choi
Summary: This study investigated the immune response and reactogenicity to the ChAdOx1 nCoV-19 vaccine based on pre-existing adenovirus immunity. It found that individuals without pre-existing adenovirus immunity showed a higher immune response and a higher frequency of reactogenicity to the ChAdOx1 nCoV-19 vaccination.
Article
Immunology
Miguel Garcia-Grimshaw, Anaclara Michel-Chavez, Juan Mauricio Vera-Zertuche, Javier Andres Galnares-Olalde, Laura E. Hernandez-Vanegas, Melissa Figueroa-Cucurachi, Orlando Paredes-Ceballos, Gustavo Reyes-Teran, Guillermo Carbajal-Sandoval, Santa Elizabeth Ceballos-Liceaga, Antonio Arauz, Sergio Ivan Valdes-Ferrer
Summary: Vaccines are the most effective way to combat the global impact of COVID-19, but hesitancy is common among minorities. Research suggests that the incidence of GBS among recipients of mRNA vaccines may align with the community-based rate, but caution is advised as the current GBS incidence among the unvaccinated population is unknown. This data aims to increase public confidence in mRNA-based vaccines and reduce hesitancy.
CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Miao Yu, Shuang Nie, Yue Qiao, Ying Ma
Summary: This study retrospectively analyzed reported Guillain-Barre syndrome (GBS) cases occurring after COVID-19 vaccination. The analysis revealed that GBS mostly occurred after the first dose of the vaccination (90%), particularly with DNA vaccines (63%). It was more common in middle-aged and elderly individuals (mean age: 54.5 years) and in men (60%). The mean time from vaccination to onset was 12.3 days. Monitoring for GBS following vaccination is recommended to establish the true incidence and association between GBS and COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Clinical Neurology
Boby Varkey Maramattom
ACTA NEUROLOGICA BELGICA
(2023)
Letter
Clinical Neurology
Boby Varkey Maramattom, Asha Kishore
ACTA NEUROLOGICA BELGICA
(2022)
Article
Cardiac & Cardiovascular Systems
Zohaib Iqbal, Bilal Bashir, Safwaan Adam, Jan H. Ho, Shaishav Dhage, Shazli Azmi, Maryam Ferdousi, Zahid Yusuf, Rachelle Donn, Rayaz A. Malik, Akheel Syed, Basil J. Ammori, Adrian Heald, Paul N. Durrington, Handrean Soran
Summary: This study investigated the effect of bariatric surgery on glycApoB levels and found that glycApoB significantly decreased after surgery, which was associated with decreased insulin resistance. The findings may help explain the effectiveness of bariatric surgery in reducing cardiovascular disease risk.
Article
Endocrinology & Metabolism
Anie Naqvi, Michelle L. MacKintosh, Abigail E. Derbyshire, Anna-Maria Tsakiroglou, Thomas D. J. Walker, Rhona J. McVey, James Bolton, Martin Fergie, Steven Bagley, Garry Ashton, Philip W. Pemberton, Akheel A. Syed, Basil J. Ammori, Richard Byers, Emma J. Crosbie
Summary: This study suggests a correlation between endometrial cancer incidence and obesity, with weight loss leading to reduced inflammation and increased protective immune cell recruitment in the endometrium, supporting the concept that immune surveillance may play a role in endometrial cancer prevention.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Review
Endocrinology & Metabolism
Saira Nawaz, Rajkumar Chinnadurai, Saif Al-Chalabi, Philip Evans, Philip A. Kalra, Akheel A. Syed, Smeeta Sinha
Summary: Obesity is directly linked to CKD through obesity-related glomerulopathy and indirectly through complications such as atherosclerosis, hypertension, and type 2 diabetes. Adipose tissue products contribute to pathophysiological processes. Preventing and managing obesity is critical in counteracting CKD development and progression.
OBESITY SCIENCE & PRACTICE
(2023)
Article
Endocrinology & Metabolism
Christopher Slater, Smrithi H. Santhosh, Jodi Ellison, Waseem Majeed, Lucinda K. M. Summers, Siba Senapati, Khurshid Akhtar, Basil J. Ammori, John P. New, Akheel A. Syed
Summary: Weight loss of 5%-10% prior to bariatric surgery is recommended, but its impact on postoperative weight loss outcomes has not been established. This study found that preoperative weight loss did not significantly influence postoperative weight loss at 12 and 24 months in patients undergoing gastric bypass or sleeve gastrectomy.
Letter
Clinical Neurology
Boby Varkey Maramattom
ACTA NEUROLOGICA BELGICA
(2023)
Editorial Material
Medicine, General & Internal
Ranjith Rajgopal, Amber Khan, Akheel A. Syed
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Letter
Endocrinology & Metabolism
Angelos Kyriacou, Akheel A. Syed, Nadia Sawicka-Gutaj, Michalis Picolos, Panayiotis Economides, Alexis Kyriacou
CLINICAL ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Andreas Leidinger, Scott L. Zuckerman, Yueqi Feng, Yitian He, Xinrui Chen, Beverly Cheserem, Linda M. Gerber, Noah L. Lessing, Hamisi K. Shabani, Roger Haertl, Halinder S. Mangat
Summary: The objective of this study was to identify determinants of decision-making for surgical intervention, improvement in function, and in-hospital mortality among patients experiencing acute spinal trauma in resource-constrained settings. The study found that operative intervention and functional improvement after acute spinal trauma in resource-restricted settings were low and inconsistent.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Letter
Clinical Neurology
Boby Varkey Maramattom, Ranjini Ramachandran Nirmala
ACTA NEUROLOGICA BELGICA
(2023)
Letter
Endocrinology & Metabolism
A. H. Heald, M. Stedman, L. Horne, R. Rea, M. B. Whyte, A. A. Syed, A. Paisley, J. M. Gibson, S. G. Anderson, W. Ollier
Article
Endocrinology & Metabolism
Salman Razvi, Avais Jabbar, Caroline Addison, Jonathan Vernazza, Akheel Syed, Handrean Soran, Owain Leng
Summary: Through analyzing the reported Thyroid Function Test (TFT) reference intervals from UK NHS laboratories, it was found that the upper limit of serum TSH and the lower limit of serum FT4 were negatively and positively associated with the prevalence of levothyroxine treatment respectively. Therefore, the reference intervals for TFT might have an impact on the use of levothyroxine treatment.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Halinder S. Mangat, Brady Rippon, Nikita T. Reddy, Akheel A. Syed, Joel M. Maruthanal, Susanne Luedtke, Jyothy J. Puthumana, Abhinash Srivatsa, Arnold Bosman, Patty Kostkova
Summary: Vaccine hesitancy is fueled by reports of rare but serious adverse events following COVID-19 immunization in young populations, leading to low vaccine uptake among children. This study examines the reported serious adverse events following COVID-19 vaccine in 5-17-year-old children in the United States, demonstrating lower risks compared to adults. The findings emphasize the importance of considering these low risks in recommending COVID-19 vaccination for children.
Article
Clinical Neurology
Hanna E. Schenck, Pascal Joackim, Albert Lazaro, Xian Wu, Linda M. Gerber, Philip E. Stieg, Roger Hartl, Hamisi Shabani, Halinder S. Mangat
Summary: This study examines the impact of the ability to pay on the management of patients with severe traumatic brain injury. The research shows that the ability to pay has a significant association with the use of head CT and a weaker association with mechanical ventilation in the management of patients with severe traumatic brain injury.
