Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 39, Pages 21277-21282Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202108987
Keywords
acylation; arylation; flow chemistry; hydrogen atom transfer; TBADT
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Funding
- European Union H2020 research and innovation program under the MarieS. Curie Grant [860762]
- European Union H2020 Erasmus+ program [OU201761]
- Marie Curie Actions (MSCA) [860762] Funding Source: Marie Curie Actions (MSCA)
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This study demonstrates a photocatalytic procedure for the acylation/arylation of unfunctionalized alkyl derivatives in flow, utilizing decatungstate anion and nickel catalyst to form C(sp(3))-C(sp(2)) bonds. The intensified conditions in flow reduce the reaction time significantly, without altering the reaction mechanism, accelerating the overall process.
Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp(3))-C(sp(2)) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced from 12-48 hours to only 5-15 minutes. Finally, kinetic measurements highlight how the intensified conditions do not change the reaction mechanism but reliably speed up the overall process.
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