Coupling Aptamer‐based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein‐Specific Glycosylation

Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction

(2020) Mengjiao Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors

(2020) Da Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ One-Step Fluorescence Labeling Strategy of Exosomes via Bioorthogonal Click Chemistry for Real-Time Exosome Tracking In Vitro and In Vivo

(2020) Sukyung Song et al.   BIOCONJUGATE CHEMISTRY

Quantitative Localized Analysis Reveals Distinct Exosomal Protein-Specific Glycosignatures: Implications in Cancer Cell Subtyping, Exosome Biogenesis, and Function

(2020) Yuna Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein S-Glyco-Modification through an Elimination–Addition Mechanism

(2020) Ke Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deconstruction of Heterogeneity of Size-Dependent Exosome Subpopulations from Human Urine by Profiling N-Glycoproteomics and Phosphoproteomics Simultaneously

(2020) Haoyang Zheng et al.   ANALYTICAL CHEMISTRY

Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance

(2020) Patrick Santos et al.   Cells

The “sugar‐coated bullets” of cancer: Tumor‐derived exosome surface glycosylation from basic knowledge to applications

(2020) Shanyi Lin et al.   Clinical and Translational Medicine

Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers

(2019) Chao Liu et al.   Nature Biomedical Engineering

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

(2019) Heng-Huan Lee et al.   CANCER CELL

Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells

(2019) Yi Hao et al.   Nature Communications

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling

(2018) Wei Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile metabolic glycan labeling strategy for exosome tracking

(2018) Tae Sup Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Amplified Visualization of Protein-Specific Glycosylation in Zebrafish via Proximity-Induced Hybridization Chain Reaction

(2018) Jingying Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Legionella effector SetA as a general O-glucosyltransferase for eukaryotic proteins

(2018) Ling Gao et al.   Nature Chemical Biology

A Single Excitation-Duplexed Imaging Strategy for Profiling Cell Surface Protein-Specific Glycoforms

(2016) Na Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

(2016) Louis Fehrenbacher et al.   LANCET

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances

(2015) Bo Cheng et al.   CHEMBIOCHEM

Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation

(2015) Peter V. Robinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

ComplexN-Linked Glycans Serve as a Determinant for Exosome/Microvesicle Cargo Recruitment

(2014) Yaxuan Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging the Glycosylation State of Cell Surface Glycoproteins by Two-Photon Fluorescence Lifetime Imaging Microscopy

(2013) Brian Belardi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Cis-Membrane FRET-Based Method for Protein-Specific Imaging of Cell-Surface Glycans

(2013) Wei Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lectin-Array Blotting: Profiling Protein Glycosylation in Complex Mixtures

(2012) Juan Etxebarria et al.   ACS Chemical Biology

Visualizing specific protein glycoforms by transmembrane fluorescence resonance energy transfer

(2012) Yoshimi Haga et al.   Nature Communications