Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 43, Pages 23225-23231Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202103874
Keywords
cancer; carbonaceous aerosol; elemental carbon; mass spectrometry imaging; organic carbon
Categories
Funding
- National Natural Sciences Foundation of China [21625504, 21827807, 21790390/21790392]
- Chinese Academy of Sciences
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In this study, a label-free mass spectrometry imaging method was proposed to visualize and quantify the behavior of carbonaceous aerosol (CA) in organs. The release behavior of organic carbon (OC) from CA in circulation to specific organs was revealed by comparing the ratio of OC to elemental carbon (EC). This technique provides deeper insights for understanding the systemic health effects of aerosol particles.
The inhalation of atmospheric particles is deleterious to human health. However, as a complex mixture, tracing the behaviors of multiple components from real aerosol particles is crucial but unachievable by the existing methods. Here, taking advantage of the intrinsic fingerprints of elemental carbon (EC) and organic carbon (OC) in carbonaceous aerosol (CA) upon laser irradiation, we proposed a label-free mass spectrometry imaging method to visualize and quantify the deposition, translocation and component variation of CA in organs. With this method, the heterogeneous deposition, clearance and release behavior of CA in lung, that more OC was released in parenchyma and OC was cleared faster than EC, was observed. The translocation of CA to extrapulmonary organs including kidney, liver, spleen and even brain was also verified and quantified. By comparing the ratio of OC to EC, an organ-specific release behavior of OC from CA during circulation was revealed. In orthotopic lung and liver tumor, OC was found to penetrate more into tumor foci than EC. This technique provides deeper information for understanding the systemic health effects of aerosol particles.
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