Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 413, Issue 28, Pages 6987-6999Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-021-03656-2
Keywords
Yolk-shell structure; Metal-organic framework; Alkaloids; Magnetic solid-phase extraction; Pharmacokinetics
Funding
- Natural Science Foundation of Chongqing, China [cstc2019jcyj-msxmX0074]
- construction project of the key specialty of Chongqing clinical pharmacy
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In this study, a magnetic yolk-shell structured metal-organic framework material (Fe3O4@YS-UiO-66-NH2) was prepared and a magnetic solid-phase extraction method was developed for the analysis of alkaloids, showing high adsorption capacity and recovery rate. The method was successfully applied in the pharmacokinetics study of alkaloids in rats.
In this study, a magnetic yolk-shell structured metal-organic framework material (Fe3O4@YS-UiO-66-NH2) is prepared by the directional etching of Co2+/peroxymonosulfate and in situ magnetization. The characteristic properties of the material were investigated by using field emission scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometer, Brunauer-Emmett-Teller, and contact angle test. The Fe3O4@YS-UiO-66-NH2 shows the advantages of large surface area, good magnetic property, and satisfactory stability, as well as giving high affinity to alkaloids (ALs) via hydrophilic interaction, hydrogen bonding, and pi-pi interaction. The results of static adsorption experiment indicate that the Fe3O4@YS-UiO-66-NH2 possesses high adsorption capacity towards ALs and the adsorption behaviors are fitted with Langmuir adsorption isotherm model. Furthermore, a magnetic solid-phase extraction using Fe3O4@YS-UiO-66-NH2 and HPLC method was developed for the analysis of ALs in spiked samples with the recovery of 89.6-100.8%. In addition, the proposed method was successfully applied in the pharmacokinetics study of berberine, coptisine, and palmatine in the rat. In short, the developed method might be used for high-efficient recognition and determination of ALs in plasma sample, which would also provide a new way to fabricate magnetic functionalized metal-organic framework in separation science.
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