Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies

Subchronic Tolerance Trials of Graded Oral Supplementation with Phenylalanine or Serine in Healthy Adults

(2021) Naoki Miura et al.   Nutrients

Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions

(2020) Hitomi Hayabuchi et al.   HYPERTENSION RESEARCH

Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial

(2020) Francisco M. Martínez-Arnau et al.   Nutrients

Tolerance to graded dosages of histidine supplementation in healthy human adults

(2020) Mary E Gheller et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Safety assessment of l-lysine oral intake: a systematic review

(2019) Kohsuke Hayamizu et al.   AMINO ACIDS

Safety of dietary supplementation with arginine in adult humans

(2018) Catherine J. McNeal et al.   AMINO ACIDS

Cysteine-derived hydrogen sulfide and gut health

(2018) François Blachier et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Effect of monosodium l-glutamate (umami substance) on cognitive function in people with dementia

(2018) Minoru Kouzuki et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Thirteen week toxicity study of dietary l -tryptophan in rats with a recovery period of 5 weeks

(2017) Yusuke Shibui et al.   JOURNAL OF APPLIED TOXICOLOGY

Protein Synthesis in Mucin-Producing Tissues Is Conserved When Dietary Threonine Is Limiting in Piglets

(2017) Lalani L Munasinghe et al.   JOURNAL OF NUTRITION

The kynurenine pathway and the brain: Challenges, controversies and promises

(2017) Robert Schwarcz et al.   NEUROPHARMACOLOGY

Comparisons of L-cysteine and D-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration

(2017) Yusuke Shibui et al.   Journal of Toxicologic Pathology

Effects of supplementation with branched-chain amino acids to low-protein diets on expression of genes related to lipid metabolism in skeletal muscle of growing pigs

(2016) Yehui Duan et al.   AMINO ACIDS

Carnitine transport and fatty acid oxidation

(2016) Nicola Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

13-week repeated dose toxicity study of l-tyrosine in rats by daily oral administration

(2016) Yusuke Shibui et al.   FOOD AND CHEMICAL TOXICOLOGY

Functions of Polyamines in Mammals

(2016) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

Proposals for Upper Limits of Safe Intake for Arginine and Tryptophan in Young Adults and an Upper Limit of Safe Intake for Leucine in the Elderly

(2016) Luc Cynober et al.   JOURNAL OF NUTRITION

Safety and Tolerability of Leucine Supplementation in Elderly Men

(2016) Rajavel Elango et al.   JOURNAL OF NUTRITION

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

(2016) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

(2016) Susan Pyne et al.   PROGRESS IN LIPID RESEARCH

The robustness of diagnostic tests for GH deficiency in adults

(2015) Marianne Andersen   GROWTH HORMONE & IGF RESEARCH

A 4-Week Toxicity Study of Methionine in Male Rats

(2015) Keigi Chin et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Sources and Amounts of Animal, Dairy, and Plant Protein Intake of US Adults in 2007–2010

(2015) Stefan Pasiakos et al.   Nutrients

Impact of supplementation with amino acids or their metabolites on muscle wasting in patients with critical illness or other muscle wasting illness: a systematic review

(2014) L. Wandrag et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men

(2014) Takuya Matsumoto et al.   SpringerPlus

Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis

(2013) Sarathi Mani et al.   CIRCULATION

Beneficial Effects of an Amino Acid Mixture on Colonic Mucosal Healing in Rats

(2013) Xinxin Liu et al.   INFLAMMATORY BOWEL DISEASES

Supplementing Healthy Women with up to 5.0 g/d of L-Tryptophan Has No Adverse Effects

(2013) Chiaki Hiratsuka et al.   JOURNAL OF NUTRITION

Physiology and Pathophysiology of Carnosine

(2013) Alexander A. Boldyrev et al.   PHYSIOLOGICAL REVIEWS

A 4-week Repeated Dose Toxicity Study of Glycine in Rats by Gavage Administration

(2013) Yusuke Shibui et al.   Journal of Toxicologic Pathology

Creatine Phosphate: Pharmacological and Clinical Perspectives

(2012) Ettore Strumia et al.   ADVANCES IN THERAPY

Lessons Learned Regarding Symptoms of Tryptophan Deficiency and Excess from Animal Requirement Studies

(2012) Soenke Moehn et al.   JOURNAL OF NUTRITION

Determination of the Tolerable Upper Intake Level of Leucine in Adult Men

(2012) Paul B. Pencharz et al.   JOURNAL OF NUTRITION

The effect of taurine on cholesterol metabolism

(2012) Wen Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cysteine fluxes across the portal-drained viscera of enterally fed minipigs: effect of an acute intestinal inflammation

(2010) Didier Rémond et al.   AMINO ACIDS

The Assessment of Individual Usual Food Intake in Large-Scale Prospective Studies

(2010) Anne-Kathrin Illner et al.   ANNALS OF NUTRITION AND METABOLISM

Toxicological evaluation of l-proline in a 90-day feeding study with Fischer 344 rats

(2010) Y. Tada et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A 90-day Feeding Toxicity Study of L-Serine in Male and Female Fischer 344 Rats

(2010) Yukie Tada et al.   Journal of Toxicologic Pathology

Metabolism and functions of l-glutamate in the epithelial cells of the small and large intestines

(2009) François Blachier et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Analysis of branched-chain α-keto acid dehydrogenase complex activity in rat tissues using α-keto[1-13C]isocaproate as substrate

(2009) Hideki Matsumoto et al.   ANALYTICAL BIOCHEMISTRY

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

(2009) Claudio Napoli et al.   ARCHIVES OF PHARMACAL RESEARCH

Trends in food and nutritional intakes of French adults from 1999 to 2007: results from the INCA surveys

(2009) Carine Dubuisson et al.   BRITISH JOURNAL OF NUTRITION

A 13-week subchronic oral toxicity study of l-serine in rats

(2009) I. Kaneko et al.   FOOD AND CHEMICAL TOXICOLOGY

A 90-day toxicity study of l-asparagine, a food additive, in F344 rats

(2008) Masanao Yokohira et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxic effects of l-aspartic acid at high dose levels on kidneys and salivary glands in Fischer 344 rats detected in a 90-day feeding study

(2008) Y. Tada et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production From Macrophages

(2008) Ayatoshi Andou et al.   GASTROENTEROLOGY

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography

(2008) Marta Ebbing et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Risk assessment for the amino acids taurine, l-glutamine and l-arginine

(2008) Andrew Shao et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology

(2007) Melissa Kemp et al.   FREE RADICAL BIOLOGY AND MEDICINE