Article
Cardiac & Cardiovascular Systems
Philipp Jud, Harald H. Kessler, Marianne Brodmann
Summary: A 24-year-old woman with Covid-19 infection exhibited reduced vascular reactivity upon diagnosis, but showed improvement after 6 weeks, suggesting a potential impact of Covid-19 infection on endothelial function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Immunology
Alexandr Ceasovschih, Victorita Sorodoc, Annabelle Shor, Raluca Ecaterina Haliga, Lynn Roth, Catalina Lionte, Viviana Onofrei Aursulesei, Oana Sirbu, Nicolae Culis, Albina Shapieva, Mohammed A. R. Tahir Khokhar, Cristian Statescu, Radu A. Sascau, Adorata Elena Coman, Alexandra Stoica, Elena-Daniela Grigorescu, Maciej Banach, Costas Thomopoulos, Laurentiu Sorodoc
Summary: The COVID-19 pandemic, which started in Wuhan, China, in early 2020, has caused a global health crisis. The disease mainly affects the respiratory system but can also have an impact on other systems, including the cardiovascular system. The relationship between atherosclerosis and COVID-19 is bidirectional, with both conditions exacerbating each other. The pandemic has also led to reduced access to healthcare amenities, an increase in sedentary lifestyles and unhealthy eating habits, resulting in a high prevalence of overweight and obese individuals. The long-term healthcare challenges posed by COVID-19 can be mitigated by the lessons learned and the advancements made in patient care during this crisis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Clinical Neurology
Min Seung Kim, Don Gueu Park, Young Eun Gil, In Ja Shin, Jung Han Yoon
Summary: It has been found that 1-year levodopa treatment may have adverse effects on vascular endothelial function in de novo PD patients. Further studies are needed to clarify the exact pathogenesis and clinical implication of levodopa-induced endothelial dysfunction in PD.
JOURNAL OF NEUROLOGY
(2023)
Article
Peripheral Vascular Disease
Dimitrios Terentes-Printzios, Vasiliki Gardikioti, Eirini Solomou, Eleni Emmanouil, Ioanna Gourgouli, Panagiotis Xydis, Georgia Christopoulou, Christos Georgakopoulos, Ioanna Dima, Antigoni Miliou, George Lazaros, Maria Pirounaki, Konstantinos Tsioufis, Charalambos Vlachopoulos
Summary: This study investigated the short-term effects of mRNA vaccine administration on endothelial function and arterial stiffness. The results showed that the mRNA vaccine caused a significant increase in inflammatory markers, especially after the second dose, and a transient deterioration of endothelial function at 24 hours, which returned to baseline at 48 hours.
HYPERTENSION RESEARCH
(2022)
Article
Clinical Neurology
Claudia Altamura, Giovanna Viticchi, Adriana Fallacara, Carmelina Maria Costa, Nicoletta Brunelli, Chiara Fiori, Mauro Silvestrini, Fabrizio Vernieri
Summary: The study found that erenumab preserves cerebral vasomotor reactivity and flow-mediated dilation in migraineurs without aura, with no significant differences compared to the control group. There was no significant correlation between responder status, treatment time, chronic conditions, and these variables.
Review
Medicine, General & Internal
Georgios Mavraganis, Maria-Angeliki Dimopoulou, Dimitrios Delialis, Dimitrios Bampatsias, Raphael Patras, Alexandros Sianis, Eleni Maneta, Kimon Stamatelopoulos, Georgios Georgiopoulos
Summary: Research suggests that endothelial dysfunction and increased arterial stiffness are associated with the severity and prognosis of COVID-19. These vascular impairments may play a crucial role in the clinical manifestations of COVID-19 and can be used for risk stratification.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Brittany Weber, Sean Parks, Daniel M. Huck, Andy Kim, Camden Bay, Jenifer M. Brown, Sanjay Divakaran, Jon Hainer, Courtney Bibbo, Viviany Taqueti, Sharmila Dorbala, Ron Blankstein, Ann E. Woolley, Marcelo F. Di Carli
Summary: This study investigated the prevalence of coronary vasomotor dysfunction in patients with previous COVID-19 infection, and found a relationship between COVID-19 infection and impaired myocardial blood flow reserve.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pediatrics
Murat Ciftel, Nurgul Ates, Osman Yilmaz
Summary: This study investigated endothelial dysfunction and arterial stiffness in patients with MIS-C, finding that patients with MIS-C exhibit endothelial dysfunction and arterial stiffness, which correlates with left ventricular dysfunction.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
S. Schnaubelt, J. Oppenauer, D. Tihanyi, M. Mueller, E. Maldonado-Gonzalez, S. Zejnilovic, H. Haslacher, T. Perkmann, R. Strassl, S. Anders, T. Stefenelli, S. Zehetmayer, R. Koppensteiner, H. Domanovits, O. Schlager
Summary: COVID-19 appears to be associated with increased arterial stiffness as reflected by higher pulse wave velocities. Higher pulse wave velocity may be related to longer hospital stay and increased mortality, particularly in non-survivors.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Biology
Zahra Ghotbi, Mehrdad Estakhr, Melika Hosseini, Reza Bavarsad Shahripour
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Endothelial dysfunction and cerebral vasomotor reactivity (VMR) impairment occur in COVID-19 patients, which is associated with a higher risk of severe disease and poor outcomes. Viruses such as Human Herpes Virus 8 and Hantavirus predominantly affect endothelial cells and impact cerebral hemodynamics. Understanding VMR can provide valuable insights for disease progression and treatment decisions in COVID-19 patients.
Article
Clinical Neurology
Sloane Heller, Claudia See, Inderjit Singh, Carolyn A. Fredericks
Summary: Pulmonary arterial hypertension (PAH) is a disease characterized by progressive pulmonary vascular remodeling, leading to increased pulmonary artery pressure and right heart dysfunction. There is evidence of cognitive impairment in PAH, but the underlying mechanism and the relationship between cardiopulmonary and cognitive dysfunction in PAH are still unknown. In this study, cognitive evaluations and sub-maximum cardiopulmonary exercise testing were performed on adult subjects with PAH. It was found that 26% of the subjects exhibited a frontal-subcortical syndrome suggestive of vascular cognitive impairment, which was associated with noninvasive markers of pulmonary vascular remodeling.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Damsara Nandadeva, Rachel J. Skow, Brandi Y. Stephens, Ann-Katrin Grotle, Stephanie Georgoudiou, Surendra Barshikar, Yaewon Seo, Paul J. Fadel
Summary: Many individuals with PASC, a condition known as postacute sequelae of COVID-19, have elevated blood pressure and central arterial stiffness, while peripheral and cerebral vascular functions remain unaffected. The severity of PASC symptoms does not correlate with cardiovascular health measures. These findings suggest that females with PASC may be at higher risk of developing hypertension independent of symptom burden.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stephen M. Ratchford, Jonathon L. Stickford, Valesha M. Province, Nina Stute, Marc A. Augenreich, Laurel K. Koontz, Landry K. Bobo, Abigail S. L. Stickford
Summary: This study found significantly lower vascular function and higher arterial stiffness in young adults weeks after testing positive for SARS-CoV-2 compared to healthy controls. These results suggest significant vascular effects persist in young adults weeks after contracting SARS-CoV-2.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Izabela Szoltysek-Boldys, Wioleta Zielinska-Danch, Danuta Loboda, Jacek Wilczek, Michal Gibinski, Elzbieta Paradowska-Nowakowska, Krzysztof S. Golba, Beata Sarecka-Hujar
Summary: Arterial stiffness in COVID-19 convalescents does not differ based on the severity and time of disease onset, but age, sex, time from disease onset, and diabetes are important determinants of arterial stiffness.
Article
Immunology
Wen-Pin Tseng, Jhong-Lin Wu, Chen-Chi Wu, Kuan-Ting Kuo, Chien-Hao Lin, Ming-Yi Chung, Ya-Fan Lee, Bey-Jing Yang, Chien-Hua Huang, Shey-Ying Chen, Chong-Jen Yu, Shyr-Chyr Chen, Po-Ren Hsueh
Summary: A seroprevalence study in Taiwan found that the prevalence of SARS-CoV-2 antibodies was extremely low among different exposure risk populations, highlighting the importance of integrated control measures in containing the spread of the virus before effective vaccines are available.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ann-Katrin Grotle, Ashley M. Darling, Erika F. Saunders, Paul J. Fadel, Daniel W. Trott, Jody L. Greaney
Summary: This study provides the first evidence of augmented T-cell mitochondrial reactive oxygen species (T-cell mitoROS) in young, otherwise healthy adults with MDD. Although the elevated T-cell mitoROS did not correspond to a proinflammatory profile, these findings suggest that elevated T-cell mitoROS may be an early marker of immune system dysregulation in young adults with MDD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Brandi Y. Stephens, Benjamin E. Young, Damsara Nandadeva, Rachel J. Skow, Ann-Katrin Grotle, Jennifer R. Vranish, Jody L. Greaney, R. M. Brothers, Paul J. Fadel
Meeting Abstract
Biochemistry & Molecular Biology
Damsara Nandadeva, Rachel J. Skow, Brandi Y. Stephens, Ann-Katrin Grotle, Paul J. Fadel
Article
Cardiac & Cardiovascular Systems
Rachel J. Skow, Damsara Nandadeva, Ann-Katrin Grotle, Brandi Y. Stephens, Alexis N. Wright, Paul J. Fadel
Summary: We demonstrate for the first time that breakthrough cases of COVID-19 during the Omicron wave do not impact vascular health and cardiac autonomic function in young adults. These findings are promising considering previous researches showing impaired vascular and autonomic function following previous variants of COVID-19. Overall, these data demonstrate that the recent Omicron variant is not detrimental to cardiovascular health in young, otherwise healthy, vaccinated adults.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Physiology
Damsara Nandadeva, Rachel J. Skow, Ann-Katrin Grotle, Brandi Y. Stephens, Benjamin E. Young, Paul J. Fadel
Summary: This study found that there was no significant difference in ambulatory daytime, nighttime, and 24-h blood pressure as well as laboratory blood pressure between control and COVID participants. However, there was a significant inverse relationship between blood pressure and time since COVID-19 diagnosis (i.e., higher blood pressure with more recent infection). Ambulatory and laboratory blood pressure variability were unaffected and not related to diagnosis time. These findings suggest that COVID-19 may only have short-lasting effects on blood pressure in young adults.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rachel J. Skow, Nicole A. Garza, Damsara Nandadeva, Brandi Y. Stephens, Alexis N. Wright, Ann-Katrin Grotle, Benjamin E. Young, Paul J. Fadel
Summary: Emerging evidence suggests that COVID-19 may affect cardiac autonomic function, but the limited findings in young adults have been inconclusive. This study found no significant differences in heart rate variability and cardiac baroreflex sensitivity between young adults with persistent symptoms following COVID-19, those who were asymptomatic, and controls who never had COVID-19. However, there were significant relationships between measures of cardiac autonomic function and time since diagnosis, suggesting that COVID-19-related changes in cardiac autonomic function are transient in young, otherwise healthy adults.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Damsara Nandadeva, Rachel J. Skow, Brandi Y. Stephens, Ann-Katrin Grotle, Stephanie Georgoudiou, Surendra Barshikar, Yaewon Seo, Paul J. Fadel
Summary: Many individuals with PASC, a condition known as postacute sequelae of COVID-19, have elevated blood pressure and central arterial stiffness, while peripheral and cerebral vascular functions remain unaffected. The severity of PASC symptoms does not correlate with cardiovascular health measures. These findings suggest that females with PASC may be at higher risk of developing hypertension independent of symptom burden.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Rachel J. Skow, Craig Steinback, Margie H. Davenport
Summary: We retrospectively analyzed data from 28 participants engaged in moderate-intensity aerobic exercise (265 sessions; 25-40 min) between 18-34 weeks gestation (NCT 02948439). The mean change in blood glucose (BG) from pre-to post-acute exercise session was -1.0 +/- 1.2 mmol/L. Pre-exercise BG significantly predicted the change in BG (p < 0.001), even when controlling for meal timing, exercise duration, and gestational age. Hypoglycemia only occurred in 3% of sessions. Therefore, in healthy pregnancy the change in BG during exercise is small and primarily related to pre-exercise BG values.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Physiology
Kanokwan Bunsawat, Heather L. Clifton, Stephen M. Ratchford, Jennifer R. Vranish, Jeremy K. Alpenglow, Mark J. Haykowsky, Joel D. Trinity, John J. Ryan, Paul J. Fadel, D. Walter Wray
Summary: The study found that patients with HFpEF have a reduced pressor response to static muscle contractions compared to healthy controls, which may be partly due to a blunted muscle metaboreflex. These findings indicate a disease-related dysregulation in neural cardiovascular control during exercise in patients with HFpEF.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Kanokwan Bunsawat, Rachel J. Skow, Jasdeep Kaur, D. Walter Wray
Summary: Patients with heart failure, both reduced and preserved ejection fraction, exhibit severe exercise intolerance due to inappropriate cardiovascular and hemodynamic adjustments to exercise. Disease-related alterations in neural mechanisms contribute to heightened sympathetic activation and impaired ability to attenuate sympathetic vasoconstrictor responsiveness in HFrEF patients, leading to reduced skeletal muscle blood flow and exercise intolerance. Less is known about these physiology aspects in HFpEF patients, but emerging data suggest dysregulated neural control of circulation, resulting in heightened sympathetic activation and attenuated skeletal muscle blood flow during exercise.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)