Article
Gastroenterology & Hepatology
Margarita Papatheodoridi, Jean Baptiste Hiriart, Monica Lupsor-Platon, Fabrizio Bronte, Jerome Boursier, Omar Elshaarawy, Fabio Marra, Maja Thiele, Georgios Markakis, Audrey Payance, Edgar Brodkin, Laurent Castera, George Papatheodoridis, Aleksander Krag, Umberto Arena, Sebastian Mueller, Paul Cales, Vincenza Calvaruso, Victor de Ledinghen, Massimo Pinzani, Emmanuel A. Tsochatzis
Summary: The study found that, compared to the dual cut-offs of <10 and >15 kPa proposed by Baveno VI, the dual cut-offs of <8 kPa (or <7 kPa for viral hepatitis) and >12 kPa have better diagnostic accuracy in cACLD.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Pik-Eu Chang, Chee-Kiat Tan, Chang-Chuen Cheah, Weiquan Li, Wan Cheng Chow, Yu-Jun Wong
Summary: The study validated the performance of the expanded Baveno-VI criteria in predicting high-risk varices in cACLD patients. Application of these criteria can safely avoid screening gastroscopy without missing more HRV.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ankur Jindal, Sanchit Sharma, Samagra Agarwal, Manoj Kumar, Anoop Saraya, Shiv Kumar Sarin
Summary: Liver stiffness measurement can be used as an alternative method to predict the risk of clinical decompensation in patients with compensated cirrhosis and to determine the need for beta-blockers.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Byeong Geun Song, Myung Ji Goh, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Seung Woon Paik, Dong Hyun Sinn
Summary: This study evaluated the usefulness of the Baveno VII consensus in predicting the risk of decompensation in patients with compensated advanced chronic liver disease (cACLD). The study found that patients with clinically significant portal hypertension (CSPH) had the highest risk of decompensation, followed by the grey zone high-risk group, grey zone low-risk group, and those without CSPH. Compared to the CSPH excluded group, the CSPH included group, grey zone high-risk group, and grey zone low-risk group had significantly higher risk of decompensation.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Nicolas Asesio, Priscila Pollo-Flores, Olivier Caliez, Mona Munteanu, An Ngo, Yen Ngo, Thierry Poynard, Dominique Thabut, Marika Rudler
Summary: This study evaluated the liver-related complications and survival of low-risk patients according to the Baveno VI criteria in patients with compensated advanced chronic liver disease (cACLD). The results showed that low-risk patients had a lower probability of acute decompensation and hepatocellular carcinoma (HCC), and the Baveno VI status was associated with acute decompensation. However, there was no significant difference in liver-related mortality between the two groups of patients.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Elton Dajti, Federico Ravaioli, Giovanni Marasco, Luigina Vanessa Alemanni, Luigi Colecchia, Alberto Ferrarese, Caterina Cusumano, Stefano Gemini, Amanda Vestito, Matteo Renzulli, Rita Golfieri, Davide Festi, Antonio Colecchia
Summary: The addition of spleen stiffness measurement (SSM) improves the diagnostic algorithm for clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Anshuman Elhence, Abhinav Anand, Sagnik Biswas, Manas Vaishnav, Rajni Yadav, Prasenjit Das, Rajesh Panwar, Sandeep Agarwal, Shivanand Gamanagatti, Ramesh Kumar, Shalimar
Summary: A two-step strategy involving lower liver stiffness measurement cut-offs and modeling based on diabetes and AST levels performs better for identifying cACLD in NAFLD patients.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, General & Internal
Faiza Sadaqat Ali, Nimrah Bader, Bader Faiyaz Zuberi, Tazeen Rasheed
Summary: This study validated the Baveno-VI recommendations for variceal screening in cACLD patients, finding a risk of missed diagnosis under these recommendations and proposing cutoff values applicable for the region. Revision of the Baveno-VI recommendations is necessary.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Christiane Stern, Laurent Castera
Summary: Non-alcoholic fatty liver disease (NAFLD) is becoming a common liver disease globally, driven by increasing rates of obesity and diabetes. The main challenge is identifying NAFLD patients with advanced fibrosis (F3F4) who are at a high risk of complications and would benefit from specialized management and new pharmacotherapies. Liver biopsy is impractical, so non-invasive sequential algorithms using fibrosis-4 index as the first-line test, followed by vibration-controlled transient elastography or patented blood tests, are recommended for identifying high-risk individuals. These strategies should be used and disseminated to increase awareness among physicians.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kento Imajo, Yasushi Honda, Takashi Kobayashi, Koki Nagai, Anna Ozaki, Michihiro Iwaki, Takaomi Kessoku, Yuji Ogawa, Hirokazu Takahashi, Yusuke Saigusa, Masato Yoneda, Hiroyuki Kirikoshi, Daisuke Utsunomiya, Shinichi Aishima, Satoru Saito, Atsushi Nakajima
Summary: MRE, VCTE, and 2D-SWE all demonstrated excellent diagnostic accuracy in detecting liver fibrosis in patients with NAFLD. MRE showed the highest diagnostic accuracy for stage 4 detection and intra- and inter-observer reproducibility.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Lucia Cerrito, Irene Mignini, Maria Elena Ainora, Carolina Mosoni, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Hepatocellular carcinoma (HCC) risk is increased in nonalcoholic fatty liver disease (NAFLD), even without cirrhosis. New noninvasive tests have been proposed to predict HCC risk, and imaging techniques evaluating liver stiffness have gained increasing importance in this context.
Article
Multidisciplinary Sciences
Tae Hyung Kim, Yoonseok Lee, Young-Sun Lee, Jeong-An Gim, Eunjung Ko, Sun Young Yim, Young Kul Jung, SeongHee Kang, Moon Young Kim, Hayeon Kim, Baek-hui Kim, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun
Summary: NASH and NAFL exhibit different miRNA expression profiles, with a combination of 4 miRNAs showing significant diagnostic accuracy for NASH, serving as a novel biomarker for NASH diagnosis in NAFLD.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Shahreedhan Shahrani, Sandeep Singh Gill, Choong Yeong Sooi, Ruben Skantha, C. Vikneshwaran Chandra Kumar, Mohd Fairul Limun, Nik Arsyad Nik Muhamad Affendi, Kee Huat Chuah, Stanley Khoo, Ruveena Bhavani Rajaram, Wah Kheong Chan, Sanjiv Mahadeva
Summary: This study found that hepatic steatosis is common in chronic liver disease, regardless of etiology. Nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis B (CHB) are the most common causes of steatosis. NAFLD has also become the leading cause of advanced fibrosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Rosa Cannistraci, Simone Mazzetti, Andrea Mortara, Gianluca Perseghin
Summary: In this population-based study, there was no independent association found between steatosis and fibrosis and cardiovascular disease. Further large prospective cohort studies are needed to provide more definitive evidence on this topic.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nobuyoshi Kawamura, Kento Imajo, Kyle J. Kalutkiewicz, Koki Nagai, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Takuma Higurashi, Kunihiro Hosono, Hirokazu Takahashi, Masato Yoneda, Satoru Saito, Shinichi Aishima, Hidenori Toyoda, Hideki Hayashi, Yoshio Sumida, Richard L. Ehman, Atsushi Nakajima
Summary: This study found that the heterogeneity of liver stiffness can impact the concordance between MRE-based fibrosis staging and biopsy staging in NAFLD patients. Inconsistent results are often associated with heterogeneous stiffness measurements.
Article
Gastroenterology & Hepatology
Huapeng Lin, Terry Cheuk-Fung Yip, Xinrong Zhang, Guanlin Li, Yee-Kit Tse, Vicki Wing-Ki Hui, Lilian Yan Liang, Jimmy Che-To Lai, Stephen Lam Chan, Henry Lik-Yuen Chan, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: The relative importance of liver-related death increases with age in patients with NAFLD, especially among women.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jian Hou, Vincent W-S Wong, Yurui Qian, Baiyan Jiang, Anthony W-H Chan, Howard H-W Leung, Grace L-H Wong, Simon C-H Yu, Winnie C-W Chu, Weitian Chen
Summary: This study used MPF-SL technology to measure macromolecule levels in the liver and found that it can detect early-stage liver fibrosis, and is not confounded by liver iron concentration or fat fraction.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medical Laboratory Technology
Stephanie C. Y. Yu, Jiaen Deng, Rong Qiao, Suk Hang Cheng, Wenlei Peng, So Ling Lau, L. Y. Lois Choy, Tak Y. Leung, John Wong, Vincent Wai-Sun Wong, Grace L. H. Wong, Peiyong Jiang, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo
Summary: Recent studies have highlighted the presence of a substantial amount of analyzable long cell-free DNA (cfDNA) in plasma through single molecule, real-time (SMRT) sequencing. In this study, the size biases of SMRT sequencing by PacBio and nanopore sequencing by ONT were evaluated. The results showed that both platforms had biases towards sequencing longer DNA fragments, with PacBio showing a stronger bias. Tissue-of-origin analysis based on single-molecule methylation patterns performed comparably on both platforms. It is important to be aware of the analytical characteristics and biases of the sequencing platforms used when analyzing the size and end motif of cfDNA.
CLINICAL CHEMISTRY
(2023)
Editorial Material
Multidisciplinary Sciences
Lei Miao, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng
Article
Medicine, General & Internal
Ibrahim Ayada, Laurens A. van Kleef, Huai Zhang, Kuan Liu, Pengfei Li, Yasir J. Abozaid, Marla Lavrijsen, Harry L. A. Janssen, Luc J. W. van der Laan, Mohsen Ghanbari, Maikel P. Peppelenbosch, Ming-Hua Zheng, Robert J. de Knegt, Qiuwei Pan
Summary: This study comprehensively investigated the potential benefits and mechanism-of-action of statins in relation to non-alcoholic fatty liver disease (NAFLD). The results showed that statin use was associated with a lower prevalence of NASH and fibrosis and might prevent NAFLD. This may be due to the anti-lipid and anti-inflammatory characteristics of statins.
Article
Gastroenterology & Hepatology
Rong Fan, Guanlin Li, Ning Yu, Xiujuan Chang, Tamoore Arshad, Wen-Yue Liu, Yan Chen, Grace Lai-Hung Wong, Yiyue Jiang, Xieer Liang, Yongpeng Chen, Xiao-Zhi Jin, Zheng Dong, Howard Ho-Wai Leung, Xiao-Dong Wang, Zhen Zeng, Terry Cheuk-Fung Yip, Qing Xie, Deming Tan, Shaoli You, Dong Ji, Jun Zhao, Arun J. Sanyal, Jian Sun, Ming-Hu Zheng, Vincent Wai-Sun Wong, Yongping Yang, Jinlin Hou
Summary: This study evaluated the performance of the aMAP score in diagnosing fibrosis in patients with chronic hepatitis B (CHB). The results showed that the aMAP score had higher accuracy in diagnosing cirrhosis and advanced fibrosis compared to other markers. The combination of aMAP and LSM further improved the accuracy in detecting cirrhosis and advanced fibrosis. The aMAP-LSM model had satisfactory performance in diagnosing fibrosis stage for treated CHB patients, especially those with a significant decrease in LSM after treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Vincenzo Falco, Guruprasad P. Aithal, Naaventhan Palaniyappan, Yusuf Yilmaz, Jerome Boursier, Christophe Cassinotto, Victor de Ledinghen, Wah Kheong Chan, Sanjiv Mahadeva, Peter Eddowes, Philip Newsome, Thomas Karlas, Johannes Wiegand, Vincent Wai-Sun Wong, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Monica Lupsor-Platon, Jeremy F. L. Cobbold, Jian-Gao Fan, Feng Shen, Katharina Staufer, Michael Trauner, Rudolf Stauber, Atsushi Nakajima, Masato Yoneda, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Ming-Hua Zheng, Calogero Camma, Quentin M. Anstee, Ferenc E. Mozes, Michael Pavlides, Salvatore Petta
Summary: This study evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The results showed that liver stiffness measurement (LSM) and AGILE 3+ were better at determining advanced fibrosis compared to serum tests. The evaluation of diagnostic methods for NAFLD with T2D is clinically significant.
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Editorial Material
Gastroenterology & Hepatology
Jacob George, George Lau, Takumi Kawaguchi, Jian-Gao Fan, Jia Ji-Dong, Fu-Sheng Wang, Manoj Kumar, Shiv Kumar Sarin, Masao Omata, Vincent Wai-Sun Wong, Mohammed Eslam
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Wah-Loong Chan, Shi-En Chong, Felicia Chang, Lee-Lee Lai, Kee-Huat Chuah, Nik Raihan Nik Mustapha, Sanjiv Mahadeva, Wah-Kheong Chan
Summary: This prospective study of MAFLD patients found that the cumulative incidence of liver-related events is low overall, but much higher among those with advanced fibrosis. However, there is a relatively high cumulative incidence of cardiovascular events among MAFLD patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Claudia Wing-Kwan Wu, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Tsz-Fai Yam, Terry Cheuk-Fung Yip, Angus Chun-Hei Wong, Brian Wai-Nok Chan, Matthew Man-Lok Fong, Jimmy Che-To Lai, Yee-Kit Tse, Kit-Fai Lee, Tony Shu-Kam Mok, Henry Lik-Yuen Chan, Rashid Nok-Shun Lui, Stephen Lam Chan, Kelvin Kwok-Chai Ng
Summary: This study evaluated the performance of Baveno VII criteria in predicting varices needing treatment (VNT) in hepatocellular carcinoma (HCC) patients at different stages. The results showed that the criteria were valid and applicable across all Barcelona Clinic Liver Cancer (BCLC) stages of HCC, as the proportion of patients with VNT was below 5% in all stages.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ru Zhang, Yunbi Ni, Cosmos L. T. Guo, Rashid N. S. Lui, William W. K. Wu, Joseph J. Y. Sung, Vincent W. S. Wong, Sunny H. Wong
Summary: This study investigated the clinical risk factors of colorectal sessile serrated lesions (SSLs) in Chinese individuals and found that dyslipidemia and diabetes were independent risk factors for SSLs.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Khean-Lee Goh, Yeong Yeh Lee, Alex Hwong-Ruey Leow, Raja Affendi Raja Ali, Shiaw Hooi Ho, Sanjiv Mahadeva, Rosaida Hj Mohd Said, Raman Muthukaruppan Chettiar, Hoi Poh Tee
Summary: There are misconceptions in Malaysian clinical practice regarding the appropriate diagnostic method and treatment strategies for Helicobacter pylori infection. To address this, an expert panel of nine key opinion leaders in gastroenterology developed a set of consensus statements relevant to the Malaysian healthcare practice. The panel achieved consensus in three areas of H. pylori infection management: indications for testing, diagnosis, and treatment. They proposed 19 consensus statements, which can serve as a guide for physicians across various healthcare settings in Malaysia.
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)