Article
Cell Biology
Bin Zheng, Zhihong Niu, Shubin Si, Guiting Zhao, Jianwei Wang, Zhongshun Yao, Fajuan Cheng, Wei He
Summary: The study identified four ferroptosis-related genes as reliable prognostic biomarkers of ccRCC, with their application value validated through immunohistochemistry and qRT-PCR, suggesting potential therapeutic targets.
Article
Oncology
Ji Chen, Yating Zhan, Rongrong Zhang, Bo Chen, Junting Huang, Chunxue Li, Wenjie Zhang, Yajing Wang, Yuxiang Gao, Jianjian Zheng, Yeping Li
Summary: This study identified 8 ferroptosis-related genes (FRGs) associated with clear cell renal cell carcinoma (ccRCC) and developed a new prognostic risk signature for predicting patient outcomes. The signature demonstrated significant value in predicting prognosis and overall survival of ccRCC patients, as well as showing correlation with immune cell infiltration. Further validation studies supported the use of this signature as an independent prognostic marker in ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Qiang Chen, Zhi-Long Li, Sheng-Qiang Fu, Si-Yuan Wang, Yu-Tang Liu, Ming Ma, Xiao-Rong Yang, Wen-Jie Xie, Bin-Bin Gong, Ting Sun
Summary: This study successfully predicted the prognosis of ccRCC patients by constructing a risk model related to RNA binding proteins, providing convenience for the identification of novel diagnostic and prognostic molecular markers.
Article
Oncology
Kaili Chang, Chong Yuan, Xueguang Liu
Summary: A study on the expression data of ferroptosis-related genes in clear-cell renal cell carcinoma (ccRCC) revealed that a prognostic signature constructed by 11 ferroptosis genes was significantly related to overall survival and could predict prognosis accurately. The signature was found to be an independent prognostic factor and provide valuable insights for individualized treatment of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zuhu Yu, Chong Lu, Bin Lu, Hong Gao, Rongfang Liang, Wuxing Xiang
Summary: This study identified necroptosis-related microRNAs (miRNAs) associated with the prognosis of clear cell renal cell carcinoma (ccRCC), and developed a prognostic signature to predict overall survival in ccRCC patients. The targeted genes of these miRNAs were predicted using miRNA databases, and their functional and pathway associations with ccRCC prognosis were investigated. The differential expression of the three miRNAs in the signature was validated in ccRCC tissues.
Article
Immunology
Yankuo Liu, Zhiyuan Shi, Jianzhong Zheng, Zeyuan Zheng, Huimin Sun, Zuodong Xuan, Yang Bai, Meiling Fu, Yifan Du, Chen Shao
Summary: Through the study of clear cell renal cell carcinoma (ccRCC) patients, ANOIKIS-related genes (ARGs) were found to be closely associated with ccRCC prognosis. The prognostic model constructed using these ARGs can effectively predict ccRCC prognosis, and these ARGs are closely related to the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Yunze Dong, Ding Liu, Hongmin Zhou, Yuchen Gao, Yimingniyizi Nueraihemaiti, Yunfei Xu
Summary: A risk model based on ccRCC patient data can effectively predict the prognosis of ccRCC patients and provide a new direction for clinical treatment. Ferroptosis-related lncRNAs have independent prognostic characteristics in ccRCC patients and are associated with oxygen metabolic processes and immune pathways.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zhenpeng Zhu, Cuijian Zhang, Jinqin Qian, Ninghan Feng, Weijie Zhu, Yang Wang, Yanqing Gong, Xuesong Li, Jian Lin, Liqun Zhou
Summary: Our study identified ferroptosis-related lncRNAs and established a prognostic signature for predicting patient survival in ccRCC. Molecular subtyping and immune infiltration differences between clusters contributed to individualizing treatment approaches.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Tuanjie Guo, Jian Zhang, Zhihao Yuan, Heting Tang, Tao Wang, Xiang Wang, Siteng Chen
Summary: Cuproptosis and its related genes (CRGs) play a significant role in the prognosis of clear cell renal cell carcinoma patients. A CRG signature was constructed to predict patient survival, and it was associated with cell cycle and mitotic signaling pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Shan Hua, Zhiwen Xie, Yongqing Zhang, Lei Wu, Fei Shi, Xingjie Wang, Shujie Xia, Shengli Dong, Juntao Jiang
Summary: By utilizing a gene signature, we can predict the immunotherapeutic response and overall survival in ccRCC patients, providing guidance for treatment selection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Guo-Jiang Zhao, Zonglong Wu, Liyuan Ge, Feilong Yang, Kai Hong, Shudong Zhang, Lulin Ma
Summary: The study identified a ferroptosis-related multi-gene expression signature for individualized prognosis prediction in patients with clear cell renal cell carcinoma (ccRCC). The seven-gene risk score model proved useful as a prognostic biomarker and potential therapeutic target for ccRCC, with significant impact on overall survival prediction for patients.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Gang Luo, Lini Wang, Ziyu Zheng, Baobao Gao, Chong Lei
Summary: We identified 36 significantly different CRFGs in KIRC and constructed a prognostic signature based on these genes. The signature was correlated with worse overall survival and could be a promising biomarker for predicting clinical outcomes in KIRC patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Oncology
Rui Zeng, Yi Li, Dong-ming He, Meng-zhu Sun, Wen-qing Huang, Yu-hang Wang, Yu-min Zhuo, Jun-jiang Chen, Tai-heng Chen, Jing-hui Guo, Jun Huang
Summary: This study aims to construct a prognostic signature for ccRCC patients based on potassium ion channel-related genes (PCRGs), assess patient risk scores, and divide patients into high- and low-risk groups based on the cutoff value. The study results demonstrate that the PCRG signature can accurately assess patient prognosis, predict the tumor microenvironment, and predict chemotherapeutic responses.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Fiorella L. Roldan, Laura Izquierdo, Mercedes Ingelmo-Torres, Juan Jose Lozano, Raquel Carrasco, Alexandra Cunado, Oscar Reig, Lourdes Mengual, Antonio Alcaraz
Summary: In this study, molecular markers for disease progression in ccRCC were identified and a gene expression-based signature was developed. This signature enhances the prediction of prognosis and could be used for personalized disease management.
Article
Biochemistry & Molecular Biology
Wei Ma, Manli Zhong, Xiaowu Liu
Summary: In this study, 297 glycolysis-associated lncRNAs were identified in ccRCC, with 7 of them found to have prognostic value. The results suggested a close association between the 7-lncRNA signature and glycolysis-related biological processes and pathways in ccRCC.
BIOSCIENCE REPORTS
(2021)
