Article
Cell Biology
Qinglin Cheng, Junfang Chen, Qingjun Jia, Zijian Fang, Gang Zhao
Summary: There are some medications such as proxalutamide, ivermectin, and low dosage bamlanivimab that appear to be associated with increasing virological cure rates in COVID-19 patients, while proxalutamide, imatinib, and baricitinib seem to be related to reducing all-cause mortality. Sotrovimab is associated with adverse events in non-severe COVID-19 patients, but no medications showed statistically significant differences when compared with placebo among severe patients.
Review
Endocrinology & Metabolism
Ying Liu, Hongbo Chen, Hui Li, Liman Li, Jin Wu, Hong Li
Summary: This meta-analysis found that metformin can significantly decrease HbA1c levels, BMI, and total daily insulin dose in adolescents with T1DM. However, it also increases the risk of hypoglycemia events and gastrointestinal adverse events. Further studies are needed to determine the optimal dosage and duration of metformin therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Critical Care Medicine
Yuki Kotani, Alessandro Pruna, Stefano Turi, Giovanni Borghi, Todd C. C. Lee, Alberto Zangrillo, Giovanni Landoni, Laura Pasin
Summary: This study conducted a systematic review and meta-analysis, and found that propofol may reduce survival in perioperative and critically ill patients compared to other hypnotic agents. Therefore, a careful assessment of the risk versus benefit of propofol compared to other agents is needed when planning for large, pragmatic multicentric randomized controlled trials to provide a definitive answer.
Review
Medicine, General & Internal
Qinglin Cheng, Gang Zhao, Junfang Chen, Qingjun Jia, Zijian Fang
Summary: This study assessed the efficacy and safety of different medications for severe COVID-19 patients through the analysis of a large number of randomized controlled trials. The results showed that drugs such as ivermectin/doxycycline, C-IVIG, and methylprednisolone were effective in reducing mortality, and most medications were safe for treating severe COVID-19. However, more large-scale randomized controlled trials are needed to confirm these findings.
Article
Virology
Qinglin Cheng, Gang Zhao, Junfang Chen, Qingjun Jia, Zijian Fang
Summary: This study showed that methylprednisolone was more effective than placebo in treating patients with severe COVID-19 infection. It also suggested that convalescent plasma (CP) may be safer and more effective compared to other treatment interventions for severe COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Behavioral Sciences
Ruibin Zhang, Charlene L. M. Lam, Xiaoling Peng, Dongming Zhang, Chichen Zhang, Ruiwang Huang, Tatia M. C. Lee
Summary: Transcranial direct current stimulation (tDCS) is considered effective in treating depression, particularly in modulating depressive symptoms. However, the differences in reducing response and remission rates did not reach statistically significant levels. tDCS may be a viable option for the treatment of depression.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Nutrition & Dietetics
Arrigo F. G. Cicero, Cormac Kennedy, Tamara Knezevic, Marilisa Bove, Coralie M. G. Georges, Agne Satrauskiene, Peter P. Toth, Federica Fogacci
Summary: Armolipid Plus(R) is a multi-constituent nutraceutical that has been shown to improve lipid profiles, with significant effects on body mass index and various cholesterol levels. Clinical trials also demonstrate that Armolipid Plus(R) is well tolerated and beneficial for improving cardiometabolic health.
Review
Pharmacology & Pharmacy
Yapeng Li, Peng Xiao, Nanyang Liu, Zhijie Zhang
Summary: Meta-analysis of multiple studies suggests that combining Lianhua Qingwen with western medicine may be more effective in treating COVID-19. It can improve total efficacy, reduce adverse events and the rate of conversion to severe cases, as well as alleviate clinical symptoms and shorten fever duration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chung-Yu Huang, Ciao-Jhih Cheng, Wen-Fei Chiou, Wei-Chiao Chang, Yi-No Kang, Mei-Hsien Lee
Summary: The systematic review and meta-analysis of 17 randomized controlled trials showed that adding Duhuo Jisheng Decoction (DHJSD) to bisphosphonate medications in the treatment of osteoporosis resulted in higher efficacy rates, increased lumbar BMD, reduced pain scores, and lower overall adverse event rates.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Hung-Jen Tang, Teng-Song Weng, Yu -Hung Chen, Chien-Ming Chao
Summary: Oral JAKis can significantly reduce the risk of death among patients with COVID-19 and are well-tolerated by hospitalized patients.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Pharmacology & Pharmacy
Liqing Niu, Lu Xiao, Xuemin Zhang, Xuezheng Liu, Xinqiao Liu, Xianglong Huang, Mingzhu Zhang
Summary: This study assessed the effectiveness of Chinese herbal injections (CHIs) in the treatment of severe pneumonia (SP) and ranked different treatment options using Bayesian network meta-analysis (NMA). The results showed that combining CHIs such as Xuebijing injection (XBJ), Tanreqing injection (TRQ), Reduning injection (RDN), and Shenmai injection (SM) with conventional Western medicine (WM) significantly improved the clinical effective rate compared to WM alone. Among them, TRQ + WM ranked the highest in terms of clinical effective rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stephen Faraone, Jeffrey H. Newcorn, Andrea Cipriani, Daniel Brandeis, Anna Kaiser, Sarah Hohmann, Alexander Haege, Samuele Cortese
Summary: The study analyzed the placebo and nocebo effects in ADHD medications, finding significant impact of placebo effects on efficacy and negative effects on tolerability. It also discovered a positive correlation between baseline to endpoint placebo effects and drug effects.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Angelina Isabella Mellentin, Sara Wallhed Finn, Lotte Skok, Daniel Thaysen-Petersen, Nicolaj Mistarz, Anders Fink-Jensen, Dorthe Gruner Nielsen
Summary: Oxytocin is being increasingly recognized for its potential in the treatment of substance use disorders (SUD). A systematic review was conducted to evaluate the efficacy of oxytocin in different SUDs. Overall, oxytocin showed some promising effects in reducing withdrawal symptoms, negative emotions, cravings, cue-induced cravings, and consumption. However, the findings were inconsistent and the trials had considerable risk of bias, requiring more methodologically sound and well-powered trials.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Saeed Aslani, Danyal Imani, Bahman Razi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: This meta-analysis demonstrates that resveratrol consumption is effective in lowering CRP and hs-CRP levels in inflammatory conditions, especially if supplementation takes place for >= 10 weeks with >= 500 mg/day.
PHYTOTHERAPY RESEARCH
(2021)
Review
Medicine, General & Internal
Xiaopei Liu, Xue Xiao, Dan Liu, Cong'e Tan
Summary: This study updated the clinical efficacy and safety of budesonide in the treatment of eosinophilic esophagitis using high-quality randomized controlled trial results, showing that oral budesonide is superior to placebo in terms of efficacy. Additionally, it was found that the efficacy of budesonide in patients is not dose-dependent.
ANNALS OF MEDICINE
(2022)
