Article
Cell Biology
Li Liu, Shengchun Liu, Haojun Luo, Chenxi Chen, Xiaoling Zhang, Lin He, Gang Tu
Summary: Resistance to Tamoxifen in ER alpha+ breast cancer patients is mediated by G-protein-coupled estrogen receptor GPR30/GPER, which upregulates HMGB1 expression and secretion in cancer associated fibroblasts (CAFs) to induce autophagy and enhance resistance to TAM in an ERK-dependent manner. Targeting GPR30 and downstream cascades may be an effective strategy to overcome this resistance.
Article
Medicine, Research & Experimental
Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
Summary: The research found that tamoxifen and its active metabolite have estrogen antagonist effects and regulate immune activation genes, while also enhancing cell phagocytosis and modifying the expression of inflammatory cytokines. These effects may be mediated through different mechanisms within the cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Hyunhee Kim, Seung-Ho Park, Jangho Lee, Gi-Jun Sung, Ji-Hye Song, Sungmin Kwak, Ji-Hoon Jeong, Min-Jeong Kong, Jin-Taek Hwang, Hyo-Kyoung Choi, Kyung-Chul Choi
Summary: This study found that TNF alpha can enhance tamoxifen sensitivity in ER alpha-positive breast cancer by degrading the key regulator NCOR1. Knockdown of NCOR1 suppressed tumor growth and promoted apoptosis in MCF7 cells and xenograft mice by stabilizing the tumor suppressor protein p53. TNF alpha treatment disrupted the complex formation of p53, ER alpha, and NCOR1, leading to enhanced suppression of tumor growth with the combination of tamoxifen, TNF alpha, and sh-NCOR1 in MCF7 xenograft mice.
Article
Biochemistry & Molecular Biology
Nidhi Chaudhary, Shikha Srivastava, Sunny Gupta, Manoj B. Menon, Ashok Kumar Patel
Summary: This study reveals the role of HMGB1 in regulating the cellular autophagy process during DENV-2 infection. Inhibition of autophagy or silencing of HMGB1 reduces DENV-2 replication, while induction of HMGB1 enhances autophagy and promotes viral replication. The HMGB1 inhibitor glycyrrhizic acid also suppresses autophagy and DENV-2 replication. Overall, HMGB1 induces BECN1 dependent autophagy to facilitate DENV-2 replication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Jingying Huang, Xuan Chan, Yuchun Lv
Summary: The study revealed a positive correlation between HMGB-1 and inflammatory cytokines, as well as a positive correlation between HMGB-1 and beclin-1 in ectopic endometrium. Results also showed upregulation of autophagy-related markers beclin-1, atg13, and p62 in the ectopic endometrium. Knockdown of HMGB-1 under hypoxic conditions suppressed inflammatory cytokines and autophagy-related markers in HESCs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Uzma Khan, Bipul Chandra Karmakar, Priyanka Basak, Sangita Paul, Animesh Gope, Deotima Sarkar, Asish Kumar Mukhopadhyay, Shanta Dutta, Sushmita Bhattacharya
Summary: This study found that glycyrrhizin can inhibit HMGB1, thereby restoring lysosomal activity, improving H. pylori infection and suppressing inflammatory response.
MOLECULAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Chengbo Wang, Maodong Leng, Cong Ding, Xiangzhan Zhu, Yaodong Zhang, Chenchen Sun, Pu Lou
Summary: This study reveals the significant roles of autophagy-dependent ferroptosis and HMGB1 in MTX-induced hepatotoxicity, and emphasizes the potential of inhibiting ferritinophagy and HMGB1 as a therapeutic approach for preventing and treating liver injury caused by MTX.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Tomoka Hisada, Naoto Kondo, Yumi Wanifuchi-Endo, Satoshi Osaga, Takashi Fujita, Tomoko Asano, Yasuaki Uemoto, Sayaka Nishikawa, Yusuke Katagiri, Mitsuo Terada, Akiko Kato, Hiroshi Sugiura, Katsuhiro Okuda, Hiroyuki Kato, Masayuki Komura, Satoshi Morita, Satoru Takahashi, Tatsuya Toyama
Summary: Co-expression of LLGL2 and SLC7A5 mRNA has a significant impact on predicting prognosis and response to tamoxifen therapy in ER alpha-positive breast cancer patients, making it a promising biomarker for early breast cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Chunyan Lei, Yongyu Li, Xiaoyan Zhu, Haijiang Li, Xiaolong Chang
Summary: The HMGB1/TLR4/MyD88 axis promotes inflammation through autophagy in the acute phase of intracerebral hemorrhage. Treatment with siRNA against HMGB1 or TLR4, as well as the autophagy inhibitor 3-MA, significantly alleviates inflammation, apoptosis, and neurological deficits associated with ICH.
Article
Oncology
Jin Young Min, Gi Ho Lee, Tilak Khanal, Sun Woo Jin, Sang-Yeop Lee, Hyung Gyun Kim, Ju-Yong Hyon, Young-Ho Chung, Sang Keun Ha, Eun Hee Han, Hye Gwang Jeong
Summary: This study investigated the correlation between hypoxia and CYP1B1 expression in breast cancer cells, finding that hypoxia induced CYP1B1 in ERα-positive breast cancer cells. HIF-1α activated ERα through direct binding, promoting CYP1B1 expression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wei Wei, Tingting Cao, Janak L. Pathak, Xintong Liu, Tianjiao Mao, Nobumoto Watanabe, Xiaomeng Li, Manli Zhang, Jiang Li
Summary: This study found that apigenin, as a single active component of herbal extract, can upregulate AQP5 expression in salivary gland cells through activation of the ER alpha signaling pathway, thus treating xerostomia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheong-Yong Yun, Nahyun Choi, Jae Un Lee, Eun Jung Lee, Ji Young Kim, Won Jun Choi, Sang Ho Oh, Jong-Hyuk Sung
Summary: This study demonstrated that the marliolide derivative DMF02 can induce melanosome degradation through autophagy pathway by activating Nrf2, leading to reduced melanin pigmentation. Additionally, DMF02 was effective in reducing UVB-induced hyperpigmentation and regulating melanosome degradation via suppression of p62. These findings suggest that Nrf2 activators could be promising therapeutic agents for reducing hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
S. Joseph Endicott, Dennis N. Boynton, Logan J. Beckmann, Richard A. Miller
Summary: This study demonstrates that CMA activity is enhanced in fed Snell dwarf mice and ghr KO mice, potentially due to changes in AKT regulation, GFAP phosphorylation, and substrate uptake activity.
Article
Medicine, Research & Experimental
Akshay Sharma, Gatha Thacker, Mukul Mishra, Anil Kumar Singh, Vishal Upadhyay, Sabyasachi Sanyal, Arun Kumar Trivedi
Summary: In this study, we found that SOX4 positively regulates FBW7 expression at the transcriptional level by binding to the FBW7 promoter. We also observed a positive correlation between SOX4 and FBW7 mRNA levels in ER+ breast cancer cell lines and patient samples. Our findings suggest that increased levels of SOX4 and FBW7 promote cancer stemness and tumor cell dormancy. Additionally, the upregulation of SOX4 enhances FBW7-mediated degradation of GATA3, leading to tamoxifen resistance.
Article
Environmental Sciences
Chunyan Yao, Xiaoling Liu, Yan Tang, Chunmei Wang, Chenggang Duan, Xiaoyan Liu, Mingliang Chen, Yumeng Zhou, Enjie Tang, Ying Xiang, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Microglia-mediated neuroinflammation is crucial in the pathophysiology of neurodegenerative diseases. Lipopolysaccharide (LPS) can activate microglia and induce inflammation. Matrix metalloproteinases (MMPs) and CD147 are key factors involved in microglial activation and inflammation. This study found that CD147 expression was induced in LPS-induced microglial activation, and inhibiting CD147 expression could suppress microglial activation. Furthermore, MMPs and autophagy were involved in the inflammatory activation of microglia, and inhibiting MMPs or autophagy could attenuate this activation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
