Article
Chemistry, Multidisciplinary
Bo Zhang, Meng Zhang, Min Lin, Xinzhe Dong, Xutao Ma, Yuanhong Xu, Jing Sun
Summary: This study reports the development of an innovative cationic copolypeptoid antimicrobial that exhibits a wide spectrum of antibacterial activity and low hemolytic properties. It effectively inhibits biofilm formation and eradicates bacteria embedded in mature biofilms. The antimicrobial also shows potent activity against drug-resistant bacteria without developing visible resistance after repeated usage.
Article
Chemistry, Multidisciplinary
Maochao Zheng, Xiaolei Wu, Chao Lu, Wancong Zhang, Shijie Tang, Ying Luo, Daojun Liu
Summary: The development of alternative antimicrobial therapeutics is needed due to the emergence of antibiotic resistance in bacterial pathogens. Polypept(o)ide-based bactericides, which mimic antimicrobial host defense peptides, have shown promise in the treatment of antibiotic-resistant and recurring infections. This review summarizes recent advances in membrane-active polypept(o)ide-based bactericides, focusing on their ability to disrupt bacterial cell walls/membranes and combat acquired antibiotic resistance and biofilm formation.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Anna Smola-Dmochowska, Kamila Lewicka, Alicja Macyk, Piotr Rychter, Elzbieta Pamula, Piotr Dobrzynski
Summary: Antibiotic resistance is a major global health and food security threat. The development of new antimicrobial therapeutics and antibacterial packaging materials is crucial for preventing and treating infectious diseases. This review highlights the significant research activities conducted in recent years in the field of polymeric materials and polymer composites with antibacterial properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu Rao, Jinghong Wang, Huanhuan Wang, Hong Wang, Rong Gu, Jie Shen, Qing Hao, John L. Brash, Hong Chen
Summary: The study demonstrates a new antibacterial agent PGB polymer, which achieves broad-spectrum antibacterial activity and excellent biocompatibility through structural optimization, making it suitable for designing antibacterial surfaces on medical devices.
Article
Chemistry, Multidisciplinary
Swagatam Barman, Sudip Mukherjee, Logia Jolly, Cassandra Troiano, Alessandro Grottesi, Debajyoti Basak, Paolo Calligari, Brinta Bhattacharjee, Gianfranco Bocchinfuso, Lorenzo Stella, Jayanta Haldar
Summary: New isoamphipathic antibacterial molecules with positional isomerism were designed and showed good antibacterial activity with low toxicity towards mammalian cells. The ortho isomer, IAM-1, exhibited strong selective activity towards bacterial membranes. Furthermore, IAM-1 demonstrated efficacy against dormant bacteria and mature biofilms, as well as moderate in vivo activity against MRSA wound infection with no detectable dermal toxicity.
Article
Biochemistry & Molecular Biology
Chih-Chien Hu, Selvaraj Rajesh Kumar, Truong Thi Tuong Vi, Yu-Tzu Huang, Dave W. Chen, Shingjiang Jessie Lue
Summary: In this study, the antimicrobial peptide GL13K was coated onto a PEEK substrate, resulting in significant antibacterial and biofilm-inhibitory effects against Staphylococcus aureus bacteria. The coating technique used in this study holds promise for providing bactericidal activity and biofilm resistance to medical implantable devices.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie Chen, You-Fu Lin, Jia-Hao Chen, Xiang Chen, Zhi-Hua Lin
Summary: The study revealed that tiger frog Cathelicidin has high antimicrobial activity, with the mature peptide showing high variability in amphibians while the cathelin domain remains conserved.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kunzhong Guo, Minjie Zhang, Junyi Cai, Zunwei Ma, Zhou Fang, Haiyan Zhou, Junjian Chen, Meng Gao, Lin Wang
Summary: In this study, AIE nanofibers were developed with precisely adjustable antibacterial activity by changing the decorated peptides. Mechanistic analysis revealed that the synergistic antibacterial activities of ROS and peptides contributed to this effect. The optimized nanofibers showed excellent antibacterial activity in vitro and in vivo, offering new opportunities for photodynamic therapy of infection.
Article
Chemistry, Multidisciplinary
Jing Sun, Xutao Ma, Rongye Li, Min Lin, Lilei Shu, Xuesi Chen
Summary: This research developed a new type of antibacterial agents by preparing pH-dependent nanostructured assemblies from cationic copolypeptoid. The fiber-like micelles demonstrated better antimicrobial performance and efficacy against biofilms, showing high selectivity.
Article
Chemistry, Medicinal
Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug, Hans -Matti Blencke, Klara Stensvag, Morten B. Strom, Annette Bayer
Summary: This study reports a promising class of antimicrobial agents, amphipathic barbiturate mimics of marine eusynstyelamides. A detailed analysis of the structure-activity relationship for cationic amphipathic barbiturates was conducted, and it was found that different cationic groups, hydrocarbon linkers, and lipophilic side chains had varying effects on their antimicrobial potency and haemolytic activity. Based on these findings, both potent narrow-spectrum and broad-spectrum barbiturates with low or no haemolytic activity were successfully prepared.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Chunming Dong, Lijun Xu, Weitao Lu, Mengru Li, Rui Zhang, Yanyan Sun, Jian Liu, Xinlei Chu
Summary: Researchers expressed a recombinant PMAP-37(F34-R) using Pichia pastoris and found that it exhibited a broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. The peptide had a minimum inhibitory concentration of 0.12-0.24 μg/mL and showed good stability. Additionally, PMAP-37(F34-R) had low hemolysis ability to mammalian cells and demonstrated a good preservative effect in plums.
MICROBIAL CELL FACTORIES
(2023)
Article
Polymer Science
Yongjin Hu, Jinghua Zhao, Jingyan Zhang, Zhiyuan Zhu, Jingyi Rao
Summary: The development of alternating polysulfoniums with excellent antibacterial activity against a broad spectrum of clinically relevant bacteria, and negligible hemolytic effect at high polymer concentrations, suggests their promising potential in combating drug-resistant bacterial infections.
Article
Food Science & Technology
Shen Yang, Mingyao Wang, Jialong Gao, Jiaxin Liu, Ritian Jin, Rong Lin, Wuyin Weng, Jude Juventus Aweya
Summary: The activity of antimicrobial peptides (AMPs) can be enhanced by low concentration of sodium chloride (NaCl), which can increase the antibacterial effect against Staphylococcus aureus. The enhancement is achieved through the destruction of bacterial structure, transformation of peptide structure, and increased binding and permeability to bacterial membranes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Wenhao Zhou, Tian Bai, Lan Wang, Yan Cheng, Dandan Xia, Sen Yu, Yufeng Zheng
Summary: The combination of antimicrobial peptides and silver nanoparticles in a silk fibroin-based coating showed excellent infection-triggered antibacterial and osteointegration properties. The coating displayed sensitive pH-responsive behavior and a high antibacterial rate. In vivo experiments demonstrated enhanced osseointegration compared to untreated titanium implants.
BIOACTIVE MATERIALS
(2023)
Article
Polymer Science
Huan-Huan Ding, Mu-Han Zhao, Le Zhai, Jian-Bin Zhen, Le-Yun Sun, Jia-Zhu Chigan, Cheng Chen, Jia-Qi Li, Han Gao, Ke-Wu Yang
Summary: The study shows that the quinine-based quaternized polymer QMTA has bactericidal effects on both drug-resistant Gram-negative E. coli and non-resistant Gram-positive bacteria B. subtilis, with a MIC value of 2 mu g mL(-1) and a bactericidal rate of over 95%. Additionally, bacteria treated with QMTA did not develop resistance even after multiple passages, and the polymer showed low toxicity at a dose of 128 mu g mL(-1). This provides a potential approach to develop new bactericidal reagent/polymer materials without resistance.